Сentral and peripheral mechanisms of mu-opioid analgesia and tolerance
Objective – An analysis of the basic science and clinical publications found in PubMed, Medline, and Web of Science. The search covered modern laboratory and clinical mechanisms of peripheral mu opioid analgesia, the role of peripheral mu receptors in systemic analgesia and the development of tolera...
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2020-03-01
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| Series: | Вестник анестезиологии и реаниматологии |
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| Online Access: | https://www.vair-journal.com/jour/article/view/398 |
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| author | Yu. A. Kolesnikov |
| author_facet | Yu. A. Kolesnikov |
| author_sort | Yu. A. Kolesnikov |
| collection | DOAJ |
| description | Objective – An analysis of the basic science and clinical publications found in PubMed, Medline, and Web of Science. The search covered modern laboratory and clinical mechanisms of peripheral mu opioid analgesia, the role of peripheral mu receptors in systemic analgesia and the development of tolerance to the analgesic effect of opioids. The review discusses the regulatory mechanisms of synthesis and transport of mu-opioid receptors in the primary afferent neurons and the molecular mechanisms responsible for modulating the conduction of nociceptive information from the periphery to the spinal cord. According to some authors, the peripheral component can account for 50-90% of the total analgesic effect after the systemic administration of morphine and methadone. The review reports on the important role of glycoprotein-P and the blood-brain barrier transport system in modulating the peripheral component of the analgesic effect of morphine as well as the synergistic interaction between central and peripheral mu receptors. The results of the reviewed studies convincingly show the key role of peripheral mu receptors in the development of tolerance to the analgesic effect of morphine after its systemic administration. The mechanisms of opioid tolerance also involve peripheral anti-opioid, pronociceptive systems such as NMDA receptors. It is well known that the same mechanisms are involved in maintaining peripheral hyperalgesia and allodynia. The development of analgesic drugs that act on peripheral antinociceptive systems offers a promising perspective on the possible treatment of acute and chronic pain. |
| format | Article |
| id | doaj-art-3dd44f9c368a487f8661b99930aa05fc |
| institution | DOAJ |
| issn | 2078-5658 2541-8653 |
| language | Russian |
| publishDate | 2020-03-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Вестник анестезиологии и реаниматологии |
| spelling | doaj-art-3dd44f9c368a487f8661b99930aa05fc2025-08-20T03:18:55ZrusNew Terra Publishing HouseВестник анестезиологии и реаниматологии2078-56582541-86532020-03-0117192010.21292/2078-5658-2020-16-1-9-20360Сentral and peripheral mechanisms of mu-opioid analgesia and toleranceYu. A. Kolesnikov0Medical Center Medicum, Pain DepartmentObjective – An analysis of the basic science and clinical publications found in PubMed, Medline, and Web of Science. The search covered modern laboratory and clinical mechanisms of peripheral mu opioid analgesia, the role of peripheral mu receptors in systemic analgesia and the development of tolerance to the analgesic effect of opioids. The review discusses the regulatory mechanisms of synthesis and transport of mu-opioid receptors in the primary afferent neurons and the molecular mechanisms responsible for modulating the conduction of nociceptive information from the periphery to the spinal cord. According to some authors, the peripheral component can account for 50-90% of the total analgesic effect after the systemic administration of morphine and methadone. The review reports on the important role of glycoprotein-P and the blood-brain barrier transport system in modulating the peripheral component of the analgesic effect of morphine as well as the synergistic interaction between central and peripheral mu receptors. The results of the reviewed studies convincingly show the key role of peripheral mu receptors in the development of tolerance to the analgesic effect of morphine after its systemic administration. The mechanisms of opioid tolerance also involve peripheral anti-opioid, pronociceptive systems such as NMDA receptors. It is well known that the same mechanisms are involved in maintaining peripheral hyperalgesia and allodynia. The development of analgesic drugs that act on peripheral antinociceptive systems offers a promising perspective on the possible treatment of acute and chronic pain.https://www.vair-journal.com/jour/article/view/398peripheral mu receptorsperipheral analgesiamorphinemethadoneopioid tolerancetopical |
| spellingShingle | Yu. A. Kolesnikov Сentral and peripheral mechanisms of mu-opioid analgesia and tolerance Вестник анестезиологии и реаниматологии peripheral mu receptors peripheral analgesia morphine methadone opioid tolerance topical |
| title | Сentral and peripheral mechanisms of mu-opioid analgesia and tolerance |
| title_full | Сentral and peripheral mechanisms of mu-opioid analgesia and tolerance |
| title_fullStr | Сentral and peripheral mechanisms of mu-opioid analgesia and tolerance |
| title_full_unstemmed | Сentral and peripheral mechanisms of mu-opioid analgesia and tolerance |
| title_short | Сentral and peripheral mechanisms of mu-opioid analgesia and tolerance |
| title_sort | сentral and peripheral mechanisms of mu opioid analgesia and tolerance |
| topic | peripheral mu receptors peripheral analgesia morphine methadone opioid tolerance topical |
| url | https://www.vair-journal.com/jour/article/view/398 |
| work_keys_str_mv | AT yuakolesnikov sentralandperipheralmechanismsofmuopioidanalgesiaandtolerance |