Modulation of Short-Chain Fatty Acids as Potential Therapy Method for Type 2 Diabetes Mellitus
In recent years, the relationship between intestinal microbiota (IM) and the pathogenesis of type 2 diabetes mellitus (T2DM) has attracted much attention. The beneficial effects of IM on the metabolic phenotype of the host are often considered to be mediated by short-chain fatty acids (SCFAs), mainl...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2021/6632266 |
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| author | Ruiqi Tang Lanjuan Li |
| author_facet | Ruiqi Tang Lanjuan Li |
| author_sort | Ruiqi Tang |
| collection | DOAJ |
| description | In recent years, the relationship between intestinal microbiota (IM) and the pathogenesis of type 2 diabetes mellitus (T2DM) has attracted much attention. The beneficial effects of IM on the metabolic phenotype of the host are often considered to be mediated by short-chain fatty acids (SCFAs), mainly acetate, butyrate, and propionate, the small-molecule metabolites derived from microbial fermentation of indigestible carbohydrates. SCFAs not only have an essential role in intestinal health but might also enter the systemic circulation as signaling molecules affecting the host’s metabolism. In this review, we summarize the effects of SCFAs on glucose homeostasis and energy homeostasis and the mechanism through which SCFAs regulate the function of metabolically active organs (brain, liver, adipose tissue, skeletal muscle, and pancreas) and discuss the potential role of modulation of SCFAs as a therapeutic method for T2DM. |
| format | Article |
| id | doaj-art-3dd2eac6513a4202a6a226d2adb6725f |
| institution | Kabale University |
| issn | 1712-9532 1918-1493 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj-art-3dd2eac6513a4202a6a226d2adb6725f2025-08-20T03:55:40ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1712-95321918-14932021-01-01202110.1155/2021/66322666632266Modulation of Short-Chain Fatty Acids as Potential Therapy Method for Type 2 Diabetes MellitusRuiqi Tang0Lanjuan Li1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Centre for Infectious Diseases, Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Centre for Infectious Diseases, Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, ChinaIn recent years, the relationship between intestinal microbiota (IM) and the pathogenesis of type 2 diabetes mellitus (T2DM) has attracted much attention. The beneficial effects of IM on the metabolic phenotype of the host are often considered to be mediated by short-chain fatty acids (SCFAs), mainly acetate, butyrate, and propionate, the small-molecule metabolites derived from microbial fermentation of indigestible carbohydrates. SCFAs not only have an essential role in intestinal health but might also enter the systemic circulation as signaling molecules affecting the host’s metabolism. In this review, we summarize the effects of SCFAs on glucose homeostasis and energy homeostasis and the mechanism through which SCFAs regulate the function of metabolically active organs (brain, liver, adipose tissue, skeletal muscle, and pancreas) and discuss the potential role of modulation of SCFAs as a therapeutic method for T2DM.http://dx.doi.org/10.1155/2021/6632266 |
| spellingShingle | Ruiqi Tang Lanjuan Li Modulation of Short-Chain Fatty Acids as Potential Therapy Method for Type 2 Diabetes Mellitus Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | Modulation of Short-Chain Fatty Acids as Potential Therapy Method for Type 2 Diabetes Mellitus |
| title_full | Modulation of Short-Chain Fatty Acids as Potential Therapy Method for Type 2 Diabetes Mellitus |
| title_fullStr | Modulation of Short-Chain Fatty Acids as Potential Therapy Method for Type 2 Diabetes Mellitus |
| title_full_unstemmed | Modulation of Short-Chain Fatty Acids as Potential Therapy Method for Type 2 Diabetes Mellitus |
| title_short | Modulation of Short-Chain Fatty Acids as Potential Therapy Method for Type 2 Diabetes Mellitus |
| title_sort | modulation of short chain fatty acids as potential therapy method for type 2 diabetes mellitus |
| url | http://dx.doi.org/10.1155/2021/6632266 |
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