Evaluation of blood glucose-lowering activity of aqueous extract of bark of Ficus lacor Buch Ham in alloxan-induced diabetes in New Zealand white rabbits
Background: Although the anti-diabetic effects of various Ficus species have been investigated in animal models, research on the blood glucose-lowering potentials of Ficus lacor Buch Ham bark remains sparse. This study evaluated the blood glucose-lowering potentials of an aqueous extract derived fro...
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Golestan University of Medical Sciences
2024-07-01
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| Series: | Medical Laboratory Journal |
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| Online Access: | http://mlj.goums.ac.ir/article-1-1685-en.pdf |
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| author | Piyushkumar Mansinh Pargi Manish Barvaliya Bhargav Purohit |
| author_facet | Piyushkumar Mansinh Pargi Manish Barvaliya Bhargav Purohit |
| author_sort | Piyushkumar Mansinh Pargi |
| collection | DOAJ |
| description | Background: Although the anti-diabetic effects of various Ficus species have been investigated in animal models, research on the blood glucose-lowering potentials of Ficus lacor Buch Ham bark remains sparse. This study evaluated the blood glucose-lowering potentials of an aqueous extract derived from Ficus labor bark in a diabetic rabbit model.
Methods: Diabetes was induced in rabbits through intravenous administration of alloxan monohydrate (120 mg/kg). 36 rabbits were divided into six groups, each consisting of six animals. Control groups included a non-diabetic control (Distilled water) and a diabetic control (Distilled water). Two experimental groups received Ficus lacor extract at doses of 100 mg/kg (Low-dose) and 200 mg/kg (High-dose) orally for six weeks. Metformin was used as an active control. A non-diabetic group (Extract control) was also administered Ficus lacor extract at 200 mg/kg. Fasting blood sugar (FBS) and post-prandial blood sugar (PP2BS) levels were measured weekly over the 6 weeks. The percentage reduction in blood glucose levels was calculated and compared for each group.
Results: The administration of both low-dose and high-dose Ficus lacor extracts resulted in significant reductions in FBS and PP2BS levels in diabetic rabbits. After six weeks, the low-dose extract group exhibited an average reduction of 38.3% in FBS and 40.5% in PP2BS, whereas the high-dose extract group showed average reductions of 35.3% in FBS and 36.3% in PP2BS.
Conclusion: The aqueous extract of Ficus lacor bark demonstrates substantial glucose-lowering activity, indicating its potential utility as a therapeutic agent in diabetes management. |
| format | Article |
| id | doaj-art-3dce336b430744d1b11ee60bc7aa3e4c |
| institution | DOAJ |
| issn | 2538-4449 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Golestan University of Medical Sciences |
| record_format | Article |
| series | Medical Laboratory Journal |
| spelling | doaj-art-3dce336b430744d1b11ee60bc7aa3e4c2025-08-20T03:08:06ZengGolestan University of Medical SciencesMedical Laboratory Journal2538-44492024-07-0118414Evaluation of blood glucose-lowering activity of aqueous extract of bark of Ficus lacor Buch Ham in alloxan-induced diabetes in New Zealand white rabbitsPiyushkumar Mansinh Pargi0Manish Barvaliya1Bhargav Purohit2 Department of Pharmacology, GMERS Medical College, Godhra, Gujarat, India-389001 Department of Pharmacology, Government Medical College, Bhavnagar, Gujarat, India-364001 Department of Pharmacology, Government Medical College, Bhavnagar, Gujarat, India-364001 Background: Although the anti-diabetic effects of various Ficus species have been investigated in animal models, research on the blood glucose-lowering potentials of Ficus lacor Buch Ham bark remains sparse. This study evaluated the blood glucose-lowering potentials of an aqueous extract derived from Ficus labor bark in a diabetic rabbit model. Methods: Diabetes was induced in rabbits through intravenous administration of alloxan monohydrate (120 mg/kg). 36 rabbits were divided into six groups, each consisting of six animals. Control groups included a non-diabetic control (Distilled water) and a diabetic control (Distilled water). Two experimental groups received Ficus lacor extract at doses of 100 mg/kg (Low-dose) and 200 mg/kg (High-dose) orally for six weeks. Metformin was used as an active control. A non-diabetic group (Extract control) was also administered Ficus lacor extract at 200 mg/kg. Fasting blood sugar (FBS) and post-prandial blood sugar (PP2BS) levels were measured weekly over the 6 weeks. The percentage reduction in blood glucose levels was calculated and compared for each group. Results: The administration of both low-dose and high-dose Ficus lacor extracts resulted in significant reductions in FBS and PP2BS levels in diabetic rabbits. After six weeks, the low-dose extract group exhibited an average reduction of 38.3% in FBS and 40.5% in PP2BS, whereas the high-dose extract group showed average reductions of 35.3% in FBS and 36.3% in PP2BS. Conclusion: The aqueous extract of Ficus lacor bark demonstrates substantial glucose-lowering activity, indicating its potential utility as a therapeutic agent in diabetes management.http://mlj.goums.ac.ir/article-1-1685-en.pdfalloxandiabetes mellitusficushyperglycemiapre-clinical |
| spellingShingle | Piyushkumar Mansinh Pargi Manish Barvaliya Bhargav Purohit Evaluation of blood glucose-lowering activity of aqueous extract of bark of Ficus lacor Buch Ham in alloxan-induced diabetes in New Zealand white rabbits Medical Laboratory Journal alloxan diabetes mellitus ficus hyperglycemia pre-clinical |
| title | Evaluation of blood glucose-lowering activity of aqueous extract of bark of Ficus lacor Buch Ham in alloxan-induced diabetes in New Zealand white rabbits |
| title_full | Evaluation of blood glucose-lowering activity of aqueous extract of bark of Ficus lacor Buch Ham in alloxan-induced diabetes in New Zealand white rabbits |
| title_fullStr | Evaluation of blood glucose-lowering activity of aqueous extract of bark of Ficus lacor Buch Ham in alloxan-induced diabetes in New Zealand white rabbits |
| title_full_unstemmed | Evaluation of blood glucose-lowering activity of aqueous extract of bark of Ficus lacor Buch Ham in alloxan-induced diabetes in New Zealand white rabbits |
| title_short | Evaluation of blood glucose-lowering activity of aqueous extract of bark of Ficus lacor Buch Ham in alloxan-induced diabetes in New Zealand white rabbits |
| title_sort | evaluation of blood glucose lowering activity of aqueous extract of bark of ficus lacor buch ham in alloxan induced diabetes in new zealand white rabbits |
| topic | alloxan diabetes mellitus ficus hyperglycemia pre-clinical |
| url | http://mlj.goums.ac.ir/article-1-1685-en.pdf |
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