Acute and Chronic Cardiovascular Manifestations of COVID-19: Role for Endotheliopathy
SARS-CoV-2, the virus that causes coronavirus disease 19 (COVID-19), is associated with a bewildering array of cardiovascular manifestations, including myocardial infarction and stroke, myocarditis and heart failure, atrial and ventricular arrhythmias, venous thromboembolism, and microvascular disea...
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| Format: | Article |
| Language: | English |
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Houston Methodist DeBakey Heart & Vascular Center
2021-12-01
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| Series: | Methodist DeBakey Cardiovascular Journal |
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| Online Access: | https://account.journal.houstonmethodist.org/index.php/up-j-mdbcj/article/view/1044 |
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| author | John P. Cooke John H. Connor Abhishek Jain |
| author_facet | John P. Cooke John H. Connor Abhishek Jain |
| author_sort | John P. Cooke |
| collection | DOAJ |
| description | SARS-CoV-2, the virus that causes coronavirus disease 19 (COVID-19), is associated with a bewildering array of cardiovascular manifestations, including myocardial infarction and stroke, myocarditis and heart failure, atrial and ventricular arrhythmias, venous thromboembolism, and microvascular disease. Accumulating evidence indicates that a profound disturbance of endothelial homeostasis contributes to these conditions. Furthermore, the pulmonary infiltration and edema, and later pulmonary fibrosis, in patients with COVID-19 is promoted by endothelial alterations including the expression of endothelial adhesion molecules and chemokines, increased intercellular permeability, and endothelial-to-mesenchyme transitions. The cognitive disturbance occurring in this disease may also be due in part to an impairment of the blood-brain barrier. Venous thrombosis and pulmonary thromboembolism are most likely associated with an endothelial defect caused by circulating inflammatory cytokines and/or direct endothelial invasion by the virus. Endothelial-targeted therapies such as statins, nitric oxide donors, and antioxidants may be useful therapeutic adjuncts in COVID-19 by restoring endothelial homeostasis. |
| format | Article |
| id | doaj-art-3dca5889cb0c4f4bad9e60d050957b40 |
| institution | Kabale University |
| issn | 1947-6108 |
| language | English |
| publishDate | 2021-12-01 |
| publisher | Houston Methodist DeBakey Heart & Vascular Center |
| record_format | Article |
| series | Methodist DeBakey Cardiovascular Journal |
| spelling | doaj-art-3dca5889cb0c4f4bad9e60d050957b402025-08-20T03:47:06ZengHouston Methodist DeBakey Heart & Vascular CenterMethodist DeBakey Cardiovascular Journal1947-61082021-12-01175536210.14797/mdcvj.10441087Acute and Chronic Cardiovascular Manifestations of COVID-19: Role for EndotheliopathyJohn P. Cooke0https://orcid.org/0000-0003-0033-9138John H. Connor1https://orcid.org/0000-0002-8867-7256Abhishek Jain2https://orcid.org/0000-0003-2235-5139Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TXBoston University Medical Center and National Emerging Infectious Diseases Laboratories, Boston University, Boston, MATexas A&M University, College Station, TX, US; Texas A&M Health Science Center, Bryan, TXSARS-CoV-2, the virus that causes coronavirus disease 19 (COVID-19), is associated with a bewildering array of cardiovascular manifestations, including myocardial infarction and stroke, myocarditis and heart failure, atrial and ventricular arrhythmias, venous thromboembolism, and microvascular disease. Accumulating evidence indicates that a profound disturbance of endothelial homeostasis contributes to these conditions. Furthermore, the pulmonary infiltration and edema, and later pulmonary fibrosis, in patients with COVID-19 is promoted by endothelial alterations including the expression of endothelial adhesion molecules and chemokines, increased intercellular permeability, and endothelial-to-mesenchyme transitions. The cognitive disturbance occurring in this disease may also be due in part to an impairment of the blood-brain barrier. Venous thrombosis and pulmonary thromboembolism are most likely associated with an endothelial defect caused by circulating inflammatory cytokines and/or direct endothelial invasion by the virus. Endothelial-targeted therapies such as statins, nitric oxide donors, and antioxidants may be useful therapeutic adjuncts in COVID-19 by restoring endothelial homeostasis.https://account.journal.houstonmethodist.org/index.php/up-j-mdbcj/article/view/1044sars-cov-2endotheliumdeep venous thrombosispulmonary embolismmyocardial infarctioncerebrovascular attackdementiamyocarditisnitric oxide |
| spellingShingle | John P. Cooke John H. Connor Abhishek Jain Acute and Chronic Cardiovascular Manifestations of COVID-19: Role for Endotheliopathy Methodist DeBakey Cardiovascular Journal sars-cov-2 endothelium deep venous thrombosis pulmonary embolism myocardial infarction cerebrovascular attack dementia myocarditis nitric oxide |
| title | Acute and Chronic Cardiovascular Manifestations of COVID-19: Role for Endotheliopathy |
| title_full | Acute and Chronic Cardiovascular Manifestations of COVID-19: Role for Endotheliopathy |
| title_fullStr | Acute and Chronic Cardiovascular Manifestations of COVID-19: Role for Endotheliopathy |
| title_full_unstemmed | Acute and Chronic Cardiovascular Manifestations of COVID-19: Role for Endotheliopathy |
| title_short | Acute and Chronic Cardiovascular Manifestations of COVID-19: Role for Endotheliopathy |
| title_sort | acute and chronic cardiovascular manifestations of covid 19 role for endotheliopathy |
| topic | sars-cov-2 endothelium deep venous thrombosis pulmonary embolism myocardial infarction cerebrovascular attack dementia myocarditis nitric oxide |
| url | https://account.journal.houstonmethodist.org/index.php/up-j-mdbcj/article/view/1044 |
| work_keys_str_mv | AT johnpcooke acuteandchroniccardiovascularmanifestationsofcovid19roleforendotheliopathy AT johnhconnor acuteandchroniccardiovascularmanifestationsofcovid19roleforendotheliopathy AT abhishekjain acuteandchroniccardiovascularmanifestationsofcovid19roleforendotheliopathy |