AUP1 and UBE2G2 complex targets STING signaling and regulates virus-induced innate immunity

AUP1 and UBE2G2 complex targets STING signaling and regulates virus-induced innate immunity

ABSTRACT Stimulator of interferon genes (STING) is an endoplasmic reticulum (ER) signaling adaptor that is essential for the host immune response triggered by DNA pathogens. Precise regulation of STING is crucial for maintaining a balanced immune response and preventing harmful autoinflammation. Act...

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Bibliographic Details
Main Authors: Xin-Tao Wang, Xi Zhu, Zhong-Hao Lian, Qian Liu, Hui-Hui Yan, Ye Qiu, Xing-Yi Ge
Format: Article
Language:English
Published: American Society for Microbiology 2025-05-01
Series:mBio
Subjects:
AUP1
UBE2G2
STING
innate immunity
virus infection
Online Access:https://journals.asm.org/doi/10.1128/mbio.00602-25
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