Prosthetic Joint Infection from Carbapenemase-Resistant Klebsiella pneumoniae Successfully Treated with Ceftazidime-Avibactam

Antimicrobial resistance in Gram-negative bacteria, particularly Enterobacteriaceae, has become a leading cause of morbidity and mortality and a serious public health concern. Gram-negative bacteria carrying extended-spectrum beta-lactamase (ESBL) enzymes now represent a significant proportion of al...

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Main Authors: A. Schimmenti, E. Brunetti, E. Seminari, B. Mariani, P. Cambieri, P. Orsolini
Format: Article
Language:English
Published: Wiley 2018-01-01
Series:Case Reports in Infectious Diseases
Online Access:http://dx.doi.org/10.1155/2018/1854805
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author A. Schimmenti
E. Brunetti
E. Seminari
B. Mariani
P. Cambieri
P. Orsolini
author_facet A. Schimmenti
E. Brunetti
E. Seminari
B. Mariani
P. Cambieri
P. Orsolini
author_sort A. Schimmenti
collection DOAJ
description Antimicrobial resistance in Gram-negative bacteria, particularly Enterobacteriaceae, has become a leading cause of morbidity and mortality and a serious public health concern. Gram-negative bacteria carrying extended-spectrum beta-lactamase (ESBL) enzymes now represent a significant proportion of all bacteria isolated from different countries worldwide. Furthermore, the increasing number of isolates carrying carbapenemases in recent years includes multidrug-resistant (MDR), extensively drug-resistant (XDR), and pandrug-resistant (PDR) bacteria. Here, we describe what, to our knowledge, is the first case of a patient with a prosthetic joint infection from carbapenemase-resistant Klebsiella pneumoniae (CRKP) successfully treated with ceftazidime-avibactam in Italy.
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id doaj-art-3dc45b3d145c4a03b4a0ff6669ed5fa0
institution OA Journals
issn 2090-6625
2090-6633
language English
publishDate 2018-01-01
publisher Wiley
record_format Article
series Case Reports in Infectious Diseases
spelling doaj-art-3dc45b3d145c4a03b4a0ff6669ed5fa02025-08-20T02:07:51ZengWileyCase Reports in Infectious Diseases2090-66252090-66332018-01-01201810.1155/2018/18548051854805Prosthetic Joint Infection from Carbapenemase-Resistant Klebsiella pneumoniae Successfully Treated with Ceftazidime-AvibactamA. Schimmenti0E. Brunetti1E. Seminari2B. Mariani3P. Cambieri4P. Orsolini5Dipartimento di Scienze Clinico-Chirurgiche, Diagnostiche e Pediatriche, Unità di Malattie Infettive e Tropicali ed Epatologia, Università di Pavia, Pavia, ItalyDipartimento di Scienze Clinico-Chirurgiche, Diagnostiche e Pediatriche, Unità di Malattie Infettive e Tropicali ed Epatologia, Università di Pavia, Pavia, ItalyUnità di Malattie Infettive e Tropicali, Fondazione IRCCS Policlinico San Matteo, Pavia, ItalyMicrobiologia e Virologia, Fondazione IRCCS Policlinico San Matteo, Pavia, ItalyMicrobiologia e Virologia, Fondazione IRCCS Policlinico San Matteo, Pavia, ItalyUnità di Malattie Infettive e Tropicali, Fondazione IRCCS Policlinico San Matteo, Pavia, ItalyAntimicrobial resistance in Gram-negative bacteria, particularly Enterobacteriaceae, has become a leading cause of morbidity and mortality and a serious public health concern. Gram-negative bacteria carrying extended-spectrum beta-lactamase (ESBL) enzymes now represent a significant proportion of all bacteria isolated from different countries worldwide. Furthermore, the increasing number of isolates carrying carbapenemases in recent years includes multidrug-resistant (MDR), extensively drug-resistant (XDR), and pandrug-resistant (PDR) bacteria. Here, we describe what, to our knowledge, is the first case of a patient with a prosthetic joint infection from carbapenemase-resistant Klebsiella pneumoniae (CRKP) successfully treated with ceftazidime-avibactam in Italy.http://dx.doi.org/10.1155/2018/1854805
spellingShingle A. Schimmenti
E. Brunetti
E. Seminari
B. Mariani
P. Cambieri
P. Orsolini
Prosthetic Joint Infection from Carbapenemase-Resistant Klebsiella pneumoniae Successfully Treated with Ceftazidime-Avibactam
Case Reports in Infectious Diseases
title Prosthetic Joint Infection from Carbapenemase-Resistant Klebsiella pneumoniae Successfully Treated with Ceftazidime-Avibactam
title_full Prosthetic Joint Infection from Carbapenemase-Resistant Klebsiella pneumoniae Successfully Treated with Ceftazidime-Avibactam
title_fullStr Prosthetic Joint Infection from Carbapenemase-Resistant Klebsiella pneumoniae Successfully Treated with Ceftazidime-Avibactam
title_full_unstemmed Prosthetic Joint Infection from Carbapenemase-Resistant Klebsiella pneumoniae Successfully Treated with Ceftazidime-Avibactam
title_short Prosthetic Joint Infection from Carbapenemase-Resistant Klebsiella pneumoniae Successfully Treated with Ceftazidime-Avibactam
title_sort prosthetic joint infection from carbapenemase resistant klebsiella pneumoniae successfully treated with ceftazidime avibactam
url http://dx.doi.org/10.1155/2018/1854805
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