Chinese population may require further venetoclax dose reduction beyond guidelines when combined with voriconazole: real-world evidence from China

Chinese population may require further venetoclax dose reduction beyond guidelines when combined with voriconazole: real-world evidence from China

ObjectiveAzole antifungals inhibit the enzyme cytochrome P450 3A4 (CYP 3A4), increasing venetoclax (VEN) levels and the risk of serious adverse reactions. Dose adjustments for VEN with voriconazole (VOR) vary in studies. The drug-drug interactions (DDI), safety and economic implications of VEN with...

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Bibliographic Details
Main Authors: Rongrong Wang, Yanfen Li, Ran Zhang, Yuan Ren, Yifan Liu, Tianlin Wang, Jin Wu, Xiangjin Zheng, Shu Li, Yu Jing
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
venetoclax
azoles
drug-drug interactions
safety
economics
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1539233/full
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