The role of neutrophils in the pathogenesis of atherosclerosis
Atherosclerosis (AS) is one of the causes of cardiovascular disease. The formation of atherosclerotic lesions of the arteries is a long process, and clinical symptoms appear already at the stage of atherosclerotic plaque (ASB), which prevents blood flow and can cause coronary heart disease, as well...
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2018-12-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/896 |
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| author | Yu. V. Saranchina S. V. Dutova O. Yu. Kilina N. V. Khanarin T. S. Kulakova |
| author_facet | Yu. V. Saranchina S. V. Dutova O. Yu. Kilina N. V. Khanarin T. S. Kulakova |
| author_sort | Yu. V. Saranchina |
| collection | DOAJ |
| description | Atherosclerosis (AS) is one of the causes of cardiovascular disease. The formation of atherosclerotic lesions of the arteries is a long process, and clinical symptoms appear already at the stage of atherosclerotic plaque (ASB), which prevents blood flow and can cause coronary heart disease, as well as acute coronary syndrome. The study of atherosclerosis mechanisms at the subclinical level is relevant. This article provides a summary of current data on the structure and functions of neutrophils (NF) in physiological processes. Particular attention is paid to the participation of neutrophils in the damage and formation of vascular endothelial dysfunction. Discusses several mechanisms of involvement of neutrophils in atherogenesis: the production of reactive oxygen species, which cause direct endothelial damage; the synthesis of cytokines that trigger the migration of leukocytes in inflammation; the formation of protein complexes with cholesterol, contributing to their deposition in the vessels, and neutrophil traps, triggering destructive-alterative reactions. |
| format | Article |
| id | doaj-art-3dbb618c36564feb820229a2d60c8030 |
| institution | DOAJ |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2018-12-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-3dbb618c36564feb820229a2d60c80302025-08-20T03:18:45Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252018-12-0117611011610.15829/1728-8800-2018-6-110-1161185The role of neutrophils in the pathogenesis of atherosclerosisYu. V. Saranchina0S. V. Dutova1O. Yu. Kilina2N. V. Khanarin3T. S. Kulakova4N.F. Katanov Khakassian State UniversityN.F. Katanov Khakassian State UniversityN.F. Katanov Khakassian State UniversityN.F. Katanov Khakassian State UniversityN.F. Katanov Khakassian State UniversityAtherosclerosis (AS) is one of the causes of cardiovascular disease. The formation of atherosclerotic lesions of the arteries is a long process, and clinical symptoms appear already at the stage of atherosclerotic plaque (ASB), which prevents blood flow and can cause coronary heart disease, as well as acute coronary syndrome. The study of atherosclerosis mechanisms at the subclinical level is relevant. This article provides a summary of current data on the structure and functions of neutrophils (NF) in physiological processes. Particular attention is paid to the participation of neutrophils in the damage and formation of vascular endothelial dysfunction. Discusses several mechanisms of involvement of neutrophils in atherogenesis: the production of reactive oxygen species, which cause direct endothelial damage; the synthesis of cytokines that trigger the migration of leukocytes in inflammation; the formation of protein complexes with cholesterol, contributing to their deposition in the vessels, and neutrophil traps, triggering destructive-alterative reactions.https://cardiovascular.elpub.ru/jour/article/view/896neutrophilsatherosclerosisatherosclerotic plaqueneutrophil trapsneutrophilic elastaseneutrophil gelatinase associated lipocaine |
| spellingShingle | Yu. V. Saranchina S. V. Dutova O. Yu. Kilina N. V. Khanarin T. S. Kulakova The role of neutrophils in the pathogenesis of atherosclerosis Кардиоваскулярная терапия и профилактика neutrophils atherosclerosis atherosclerotic plaque neutrophil traps neutrophilic elastase neutrophil gelatinase associated lipocaine |
| title | The role of neutrophils in the pathogenesis of atherosclerosis |
| title_full | The role of neutrophils in the pathogenesis of atherosclerosis |
| title_fullStr | The role of neutrophils in the pathogenesis of atherosclerosis |
| title_full_unstemmed | The role of neutrophils in the pathogenesis of atherosclerosis |
| title_short | The role of neutrophils in the pathogenesis of atherosclerosis |
| title_sort | role of neutrophils in the pathogenesis of atherosclerosis |
| topic | neutrophils atherosclerosis atherosclerotic plaque neutrophil traps neutrophilic elastase neutrophil gelatinase associated lipocaine |
| url | https://cardiovascular.elpub.ru/jour/article/view/896 |
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