The role of prostatitis in prostate cancer: meta-analysis.
<h4>Objective</h4>Use systematic review methods to quantify the association between prostatitis and prostate cancer, under both fixed and random effects model.<h4>Evidence acquisition</h4>Case control studies of prostate cancer with information on prostatitis history. All stu...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0085179&type=printable |
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| author | Junyi Jiang Jinyi Li Zhang Yunxia Hong Zhu Junjiang Liu Chris Pumill |
| author_facet | Junyi Jiang Jinyi Li Zhang Yunxia Hong Zhu Junjiang Liu Chris Pumill |
| author_sort | Junyi Jiang |
| collection | DOAJ |
| description | <h4>Objective</h4>Use systematic review methods to quantify the association between prostatitis and prostate cancer, under both fixed and random effects model.<h4>Evidence acquisition</h4>Case control studies of prostate cancer with information on prostatitis history. All studies published between 1990-2012, were collected to calculate a pooled odds ratio.<h4>Selection criteria</h4>the selection criteria are as follows: human case control studies; published from May 1990 to July 2012; containing number of prostatitis, and prostate cancer cases.<h4>Evidence synthesis</h4>In total, 20 case control studies were included. A significant association between prostatitis and prostate cancer was found, under both fixed effect model (pooled OR=1.50, 95%CI: 1.39-1.62), and random effects model (OR=1.64, 95%CI: 1.36-1.98). Personal interview based case control studies showed a high level of association (fixed effect model: pooled OR=1.59, 95%CI: 1.47-1.73, random effects model: pooled OR= 1.87, 95%CI: 1.52-2.29), compared with clinical based studies (fixed effect model: pooled OR=1.05, 95%CI: 0.86-1.28, random effects model: pooled OR= 0.98, 95%CI: 0.67-1.45). Additionally, pooled ORs, were calculated for each decade. In a fixed effect model: 1990's: OR=1.58, 95% CI: 1.35-1.84; 2000's: OR=1.59, 95% CI: 1.40-1.79; 2010's: OR=1.37, 95% CI: 1.22-1.56. In a random effects model: 1990's: OR=1.98, 95% CI: 1.08-3.62; 2000's: OR=1.64, 95% CI: 1.23-2.19; 2010's: OR=1.34, 95% CI: 1.03-1.73. Finally a meta-analysis stratified by each country was conducted. In fixed effect models, U.S: pooled OR =1.45, 95%CI: 1.34-1.57; China: pooled OR =4.67, 95%CI: 3.08-7.07; Cuba: pooled OR =1.43, 95%CI: 1.00-2.04; Italy: pooled OR =0.61, 95%CI: 0.13-2.90. In random effects model, U.S: pooled OR=1.50, 95%CI: 1.25-1.80; China: pooled OR =4.67, 95%CI: 3.08-7.07; Cuba: pooled OR =1.43, 95%CI: 1.00-2.04; Italy: pooled OR =0.61, 95%CI: 0.13-2.90.<h4>Conclusions</h4>the present meta-analysis provides the statistical evidence that the association between prostatitis and prostate cancer is significant. |
| format | Article |
| id | doaj-art-3db7cf0764bd40b18e0a116b4d55e2d7 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj-art-3db7cf0764bd40b18e0a116b4d55e2d72025-08-20T02:37:03ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01812e8517910.1371/journal.pone.0085179The role of prostatitis in prostate cancer: meta-analysis.Junyi JiangJinyi LiZhang YunxiaHong ZhuJunjiang LiuChris Pumill<h4>Objective</h4>Use systematic review methods to quantify the association between prostatitis and prostate cancer, under both fixed and random effects model.<h4>Evidence acquisition</h4>Case control studies of prostate cancer with information on prostatitis history. All studies published between 1990-2012, were collected to calculate a pooled odds ratio.<h4>Selection criteria</h4>the selection criteria are as follows: human case control studies; published from May 1990 to July 2012; containing number of prostatitis, and prostate cancer cases.<h4>Evidence synthesis</h4>In total, 20 case control studies were included. A significant association between prostatitis and prostate cancer was found, under both fixed effect model (pooled OR=1.50, 95%CI: 1.39-1.62), and random effects model (OR=1.64, 95%CI: 1.36-1.98). Personal interview based case control studies showed a high level of association (fixed effect model: pooled OR=1.59, 95%CI: 1.47-1.73, random effects model: pooled OR= 1.87, 95%CI: 1.52-2.29), compared with clinical based studies (fixed effect model: pooled OR=1.05, 95%CI: 0.86-1.28, random effects model: pooled OR= 0.98, 95%CI: 0.67-1.45). Additionally, pooled ORs, were calculated for each decade. In a fixed effect model: 1990's: OR=1.58, 95% CI: 1.35-1.84; 2000's: OR=1.59, 95% CI: 1.40-1.79; 2010's: OR=1.37, 95% CI: 1.22-1.56. In a random effects model: 1990's: OR=1.98, 95% CI: 1.08-3.62; 2000's: OR=1.64, 95% CI: 1.23-2.19; 2010's: OR=1.34, 95% CI: 1.03-1.73. Finally a meta-analysis stratified by each country was conducted. In fixed effect models, U.S: pooled OR =1.45, 95%CI: 1.34-1.57; China: pooled OR =4.67, 95%CI: 3.08-7.07; Cuba: pooled OR =1.43, 95%CI: 1.00-2.04; Italy: pooled OR =0.61, 95%CI: 0.13-2.90. In random effects model, U.S: pooled OR=1.50, 95%CI: 1.25-1.80; China: pooled OR =4.67, 95%CI: 3.08-7.07; Cuba: pooled OR =1.43, 95%CI: 1.00-2.04; Italy: pooled OR =0.61, 95%CI: 0.13-2.90.<h4>Conclusions</h4>the present meta-analysis provides the statistical evidence that the association between prostatitis and prostate cancer is significant.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0085179&type=printable |
| spellingShingle | Junyi Jiang Jinyi Li Zhang Yunxia Hong Zhu Junjiang Liu Chris Pumill The role of prostatitis in prostate cancer: meta-analysis. PLoS ONE |
| title | The role of prostatitis in prostate cancer: meta-analysis. |
| title_full | The role of prostatitis in prostate cancer: meta-analysis. |
| title_fullStr | The role of prostatitis in prostate cancer: meta-analysis. |
| title_full_unstemmed | The role of prostatitis in prostate cancer: meta-analysis. |
| title_short | The role of prostatitis in prostate cancer: meta-analysis. |
| title_sort | role of prostatitis in prostate cancer meta analysis |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0085179&type=printable |
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