Bioengineered Anthocyanin-Enriched Tomatoes: A Novel Approach to Colorectal Cancer Prevention
Colorectal cancer (CRC) remains a significant global health challenge, with barriers to effective prevention and treatment including tumor recurrence, chemoresistance, and limited overall survival rates. Anthocyanins, known for their strong anti-cancer properties, have shown promise in preventing an...
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| Format: | Article |
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MDPI AG
2024-09-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/13/18/2991 |
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| author | Md Suzauddula Kaori Kobayashi Sunghun Park Xiuzhi Susan Sun Weiqun Wang |
| author_facet | Md Suzauddula Kaori Kobayashi Sunghun Park Xiuzhi Susan Sun Weiqun Wang |
| author_sort | Md Suzauddula |
| collection | DOAJ |
| description | Colorectal cancer (CRC) remains a significant global health challenge, with barriers to effective prevention and treatment including tumor recurrence, chemoresistance, and limited overall survival rates. Anthocyanins, known for their strong anti-cancer properties, have shown promise in preventing and suppressing various cancers, including CRC. However, natural sources of anthocyanins often fail to provide sufficient quantities needed for therapeutic effects. Bioengineered crops, particularly anthocyanin-enriched tomatoes, offer a viable solution to enhance anthocyanin content. Given its large-scale production and consumption, tomatoes present an ideal target for bioengineering efforts aimed at increasing dietary anthocyanin intake. This review provides an overview of anthocyanins and their health benefits, elucidating the mechanisms by which anthocyanins modulate the transcription factors involved in CRC development. It also examines case studies demonstrating the successful bioengineering of tomatoes to boost anthocyanin levels. Furthermore, the review discusses the effects of anthocyanin extracts from bioengineered tomatoes on CRC prevention, highlighting their role in altering metabolic pathways and reducing tumor-related inflammation. Finally, this review addresses the challenges associated with bioengineering tomatoes and proposes future research directions to optimize anthocyanin enrichment in tomatoes. |
| format | Article |
| id | doaj-art-3db7c6c8b5bd4fd5a72c8525cdd3ad16 |
| institution | OA Journals |
| issn | 2304-8158 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj-art-3db7c6c8b5bd4fd5a72c8525cdd3ad162025-08-20T01:55:27ZengMDPI AGFoods2304-81582024-09-011318299110.3390/foods13182991Bioengineered Anthocyanin-Enriched Tomatoes: A Novel Approach to Colorectal Cancer PreventionMd Suzauddula0Kaori Kobayashi1Sunghun Park2Xiuzhi Susan Sun3Weiqun Wang4Department of Food Nutrition Dietetics and Health, Kansas State University, Manhattan, KS 66506, USADepartment of Food Nutrition Dietetics and Health, Kansas State University, Manhattan, KS 66506, USADepartment of Horticulture and Nature Resources, Kansas State University, Manhattan, KS 66506, USADepartment of Grain Science and Industry, Kansas State University, Manhattan, KS 66506, USADepartment of Food Nutrition Dietetics and Health, Kansas State University, Manhattan, KS 66506, USAColorectal cancer (CRC) remains a significant global health challenge, with barriers to effective prevention and treatment including tumor recurrence, chemoresistance, and limited overall survival rates. Anthocyanins, known for their strong anti-cancer properties, have shown promise in preventing and suppressing various cancers, including CRC. However, natural sources of anthocyanins often fail to provide sufficient quantities needed for therapeutic effects. Bioengineered crops, particularly anthocyanin-enriched tomatoes, offer a viable solution to enhance anthocyanin content. Given its large-scale production and consumption, tomatoes present an ideal target for bioengineering efforts aimed at increasing dietary anthocyanin intake. This review provides an overview of anthocyanins and their health benefits, elucidating the mechanisms by which anthocyanins modulate the transcription factors involved in CRC development. It also examines case studies demonstrating the successful bioengineering of tomatoes to boost anthocyanin levels. Furthermore, the review discusses the effects of anthocyanin extracts from bioengineered tomatoes on CRC prevention, highlighting their role in altering metabolic pathways and reducing tumor-related inflammation. Finally, this review addresses the challenges associated with bioengineering tomatoes and proposes future research directions to optimize anthocyanin enrichment in tomatoes.https://www.mdpi.com/2304-8158/13/18/2991anthocyaninsbioengineered tomatoesanthocyanin-enriched tomatoescolorectal cancercancer prevention |
| spellingShingle | Md Suzauddula Kaori Kobayashi Sunghun Park Xiuzhi Susan Sun Weiqun Wang Bioengineered Anthocyanin-Enriched Tomatoes: A Novel Approach to Colorectal Cancer Prevention Foods anthocyanins bioengineered tomatoes anthocyanin-enriched tomatoes colorectal cancer cancer prevention |
| title | Bioengineered Anthocyanin-Enriched Tomatoes: A Novel Approach to Colorectal Cancer Prevention |
| title_full | Bioengineered Anthocyanin-Enriched Tomatoes: A Novel Approach to Colorectal Cancer Prevention |
| title_fullStr | Bioengineered Anthocyanin-Enriched Tomatoes: A Novel Approach to Colorectal Cancer Prevention |
| title_full_unstemmed | Bioengineered Anthocyanin-Enriched Tomatoes: A Novel Approach to Colorectal Cancer Prevention |
| title_short | Bioengineered Anthocyanin-Enriched Tomatoes: A Novel Approach to Colorectal Cancer Prevention |
| title_sort | bioengineered anthocyanin enriched tomatoes a novel approach to colorectal cancer prevention |
| topic | anthocyanins bioengineered tomatoes anthocyanin-enriched tomatoes colorectal cancer cancer prevention |
| url | https://www.mdpi.com/2304-8158/13/18/2991 |
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