HIV-1 infection of macrophages differentially primes NK-cell cytotoxicity and proinflammatory cytokine production

HIV-1 infection of macrophages differentially primes NK-cell cytotoxicity and proinflammatory cytokine production

Summary: Natural killer (NK) cells are innate cytotoxic lymphocytes with antiviral functions explored in “shock and kill” strategies to eliminate the HIV-1 reservoir. For optimal activity against infected targets, NK cells require priming. This study examined how macrophages prime NK cells following...

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Main Authors: Leonore Mensching, Maya Beiersdorfer, Sebastian Schloer, Sandra Köllmann, Friederike Reinsberg, Benedetta Padoan, Pia Fittje, Timo Trenkner, Annika Zaayenga, Gloria Martrus, Maher Almahfoud, Christina M. Stürzel, Daniel Sauter, Frank Kirchhoff, Julian Schulze zur Wiesch, Marcus Altfeld, Wilfredo F. Garcia-Beltran, Angelique Hoelzemer
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:iScience
Subjects:
Immunology
Immune response
Virology
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422501140X
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