Humanized mouse model reveals the immunogenicity of Hepatitis B Virus vaccine candidates produced in CRISPR/Cas9-edited Nicotiana benthamiana

Humanized mouse model reveals the immunogenicity of Hepatitis B Virus vaccine candidates produced in CRISPR/Cas9-edited Nicotiana benthamiana

IntroductionHepatitis B Virus (HBV) infection is still an ongoing public health issue worldwide. The most efficient tool in preventing HBV infection remains vaccination and significant efforts have been made in the last decade to improve current HBV vaccines. Owing to the strict HBV tropism for the...

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Main Authors: Iuliana Caras, Irina-Elena Ionescu, Ana-Maria Pantazica, André van Eerde, Hege Steen, Inger Heldal, Sissel Haugslien, Catalin Tucureanu, Raluca-Elena Chelmus, Vlad-Constantin Tofan, Adriana Costache, Adrian Onu, Hang Su, Norica Branza-Nichita, Jihong Liu-Clarke, Crina Stavaru
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
HBV
humanized mice
virus-neutralization
chimeric antigen
CRISPR/Cas9-edited Nicotiana benthamiana
immune response
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1479689/full
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