The First Comprehensive Evaluation of Immuno-Inflammatory Markers for Prognosis in Esophageal Cancer Patients: A South Asian Perspective
<b>Background:</b> Esophageal cancer (EC) remains a significant health challenge in South Asia, with poor prognosis despite advancements in diagnostics and treatment. Identifying and validating prognostic factors is essential for improving patient outcomes. <b>Methods:</b> A...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-10-01
|
| Series: | Clinics and Practice |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2039-7283/14/5/163 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850204574862802944 |
|---|---|
| author | Sajida Qureshi Waqas Ahmad Abbasi Hira Abdul Jalil Saba Mughal Muhammad Saeed Quraishy |
| author_facet | Sajida Qureshi Waqas Ahmad Abbasi Hira Abdul Jalil Saba Mughal Muhammad Saeed Quraishy |
| author_sort | Sajida Qureshi |
| collection | DOAJ |
| description | <b>Background:</b> Esophageal cancer (EC) remains a significant health challenge in South Asia, with poor prognosis despite advancements in diagnostics and treatment. Identifying and validating prognostic factors is essential for improving patient outcomes. <b>Methods:</b> A prospective study was conducted with 146 biopsy-confirmed EC patients at the Dr. Ruth K.M. Pfau Civil Hospital, Karachi, Pakistan. Clinical and laboratory data were collected and analyzed using descriptive statistics, receiver operating characteristic (ROC) analysis, and the Chi-square test. Survival outcomes were assessed using Kaplan–Meier curves, log-rank tests, and Cox proportional hazard models for univariate and multivariate regression analyses, with statistical significance set at <i>p</i> ≤ 0.05. <b>Results:</b> Bivariate analysis showed significant associations of the neutrophil lymphocyte ratio (NLR) (<i>p</i> = 0.017), C-reactive protein to albumin ratio (CAR) (<i>p</i> = 0.033), red cell distribution width to platelet ratio (RPR) (<i>p</i> = 0.020), and systemic immune-Inflammation index (SII) (<i>p</i> = 0.009) with patient survival. Univariate analysis identified tumor length >10 cm (<i>p</i> = 0.016), T4 stage (<i>p</i> = 0.015), metastasis (<i>p</i> < 0.001), surgery not performed (<i>p</i> < 0.001), and SII (<i>p</i> = 0.022) as significant factors for survival, with higher SII linked to poorer overall survival (<i>p</i> = 0.020). Interestingly, in the multivariate model, only metastasis (<i>p</i> < 0.001) and surgery not performed (<i>p</i> = 0.011) remained significant. <b>Conclusions:</b> Immuno-inflammatory markers may be less pertinent prognostic factors for EC in the South Asian population. |
| format | Article |
| id | doaj-art-3dac36bb3d04417bb908e5a78f76578c |
| institution | OA Journals |
| issn | 2039-7283 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Clinics and Practice |
| spelling | doaj-art-3dac36bb3d04417bb908e5a78f76578c2025-08-20T02:11:15ZengMDPI AGClinics and Practice2039-72832024-10-011452071207910.3390/clinpract14050163The First Comprehensive Evaluation of Immuno-Inflammatory Markers for Prognosis in Esophageal Cancer Patients: A South Asian PerspectiveSajida Qureshi0Waqas Ahmad Abbasi1Hira Abdul Jalil2Saba Mughal3Muhammad Saeed Quraishy4Dow Medical College, Dow University of Health Sciences, Karachi 74200, PakistanDow Medical College, Dow University of Health Sciences, Karachi 74200, PakistanDow Medical College, Dow University of Health Sciences, Karachi 74200, PakistanSchool of Public Health, Dow University of Health Sciences, Ojha Campus, Karachi 75300, PakistanDow Medical College, Dow University of Health Sciences, Karachi 74200, Pakistan<b>Background:</b> Esophageal cancer (EC) remains a significant health challenge in South Asia, with poor prognosis despite advancements in diagnostics and treatment. Identifying and validating prognostic factors is essential for improving patient outcomes. <b>Methods:</b> A prospective study was conducted with 146 biopsy-confirmed EC patients at the Dr. Ruth K.M. Pfau Civil Hospital, Karachi, Pakistan. Clinical and laboratory data were collected and analyzed using descriptive statistics, receiver operating characteristic (ROC) analysis, and the Chi-square test. Survival outcomes were assessed using Kaplan–Meier curves, log-rank tests, and Cox proportional hazard models for univariate and multivariate regression analyses, with statistical significance set at <i>p</i> ≤ 0.05. <b>Results:</b> Bivariate analysis showed significant associations of the neutrophil lymphocyte ratio (NLR) (<i>p</i> = 0.017), C-reactive protein to albumin ratio (CAR) (<i>p</i> = 0.033), red cell distribution width to platelet ratio (RPR) (<i>p</i> = 0.020), and systemic immune-Inflammation index (SII) (<i>p</i> = 0.009) with patient survival. Univariate analysis identified tumor length >10 cm (<i>p</i> = 0.016), T4 stage (<i>p</i> = 0.015), metastasis (<i>p</i> < 0.001), surgery not performed (<i>p</i> < 0.001), and SII (<i>p</i> = 0.022) as significant factors for survival, with higher SII linked to poorer overall survival (<i>p</i> = 0.020). Interestingly, in the multivariate model, only metastasis (<i>p</i> < 0.001) and surgery not performed (<i>p</i> = 0.011) remained significant. <b>Conclusions:</b> Immuno-inflammatory markers may be less pertinent prognostic factors for EC in the South Asian population.https://www.mdpi.com/2039-7283/14/5/163esophageal cancerprognosisinflammationSouth Asia |
| spellingShingle | Sajida Qureshi Waqas Ahmad Abbasi Hira Abdul Jalil Saba Mughal Muhammad Saeed Quraishy The First Comprehensive Evaluation of Immuno-Inflammatory Markers for Prognosis in Esophageal Cancer Patients: A South Asian Perspective Clinics and Practice esophageal cancer prognosis inflammation South Asia |
| title | The First Comprehensive Evaluation of Immuno-Inflammatory Markers for Prognosis in Esophageal Cancer Patients: A South Asian Perspective |
| title_full | The First Comprehensive Evaluation of Immuno-Inflammatory Markers for Prognosis in Esophageal Cancer Patients: A South Asian Perspective |
| title_fullStr | The First Comprehensive Evaluation of Immuno-Inflammatory Markers for Prognosis in Esophageal Cancer Patients: A South Asian Perspective |
| title_full_unstemmed | The First Comprehensive Evaluation of Immuno-Inflammatory Markers for Prognosis in Esophageal Cancer Patients: A South Asian Perspective |
| title_short | The First Comprehensive Evaluation of Immuno-Inflammatory Markers for Prognosis in Esophageal Cancer Patients: A South Asian Perspective |
| title_sort | first comprehensive evaluation of immuno inflammatory markers for prognosis in esophageal cancer patients a south asian perspective |
| topic | esophageal cancer prognosis inflammation South Asia |
| url | https://www.mdpi.com/2039-7283/14/5/163 |
| work_keys_str_mv | AT sajidaqureshi thefirstcomprehensiveevaluationofimmunoinflammatorymarkersforprognosisinesophagealcancerpatientsasouthasianperspective AT waqasahmadabbasi thefirstcomprehensiveevaluationofimmunoinflammatorymarkersforprognosisinesophagealcancerpatientsasouthasianperspective AT hiraabduljalil thefirstcomprehensiveevaluationofimmunoinflammatorymarkersforprognosisinesophagealcancerpatientsasouthasianperspective AT sabamughal thefirstcomprehensiveevaluationofimmunoinflammatorymarkersforprognosisinesophagealcancerpatientsasouthasianperspective AT muhammadsaeedquraishy thefirstcomprehensiveevaluationofimmunoinflammatorymarkersforprognosisinesophagealcancerpatientsasouthasianperspective AT sajidaqureshi firstcomprehensiveevaluationofimmunoinflammatorymarkersforprognosisinesophagealcancerpatientsasouthasianperspective AT waqasahmadabbasi firstcomprehensiveevaluationofimmunoinflammatorymarkersforprognosisinesophagealcancerpatientsasouthasianperspective AT hiraabduljalil firstcomprehensiveevaluationofimmunoinflammatorymarkersforprognosisinesophagealcancerpatientsasouthasianperspective AT sabamughal firstcomprehensiveevaluationofimmunoinflammatorymarkersforprognosisinesophagealcancerpatientsasouthasianperspective AT muhammadsaeedquraishy firstcomprehensiveevaluationofimmunoinflammatorymarkersforprognosisinesophagealcancerpatientsasouthasianperspective |