Cardiovascular disease and its risk factors among people living with HIV: A systematic review and meta-analysis
This meta-analysis aimed to quantify the latest cardiovascular disease (CVD) incidence rate and assess the impact of risk factors among people living with HIV (PLWH). We searched PubMed, Embase, Web of Science, Scopus, and the Cochrane Library for studies published up to September 14, 2023. To evalu...
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Elsevier
2025-02-01
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| Series: | Journal of Infection and Public Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1876034125000036 |
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| author | Min Du Shimo Zhang Min Liu Jue Liu |
| author_facet | Min Du Shimo Zhang Min Liu Jue Liu |
| author_sort | Min Du |
| collection | DOAJ |
| description | This meta-analysis aimed to quantify the latest cardiovascular disease (CVD) incidence rate and assess the impact of risk factors among people living with HIV (PLWH). We searched PubMed, Embase, Web of Science, Scopus, and the Cochrane Library for studies published up to September 14, 2023. To evaluate effect sizes, we employed multilevel (three-level) random-effects meta-analyses. The pooled incidence rate of CVD was 6.31 per 1000 person-years. Among the 14 risk factors analyzed, the most prevalent was a history of CVD (odds ratio [OR]=3.47), followed by age (per 10-year increase) (OR=1.79), current smoking (OR=1.76), hypertension (OR=1.57), smoking (OR=1.53), diabetes (OR=1.50), previous smoking (OR=1.30), and hepatitis C virus (HCV) infection (OR=1.18). However, there was no statistical significance associated with HIV-specific factors (abacavir use, efavirenz use, and CD4 nadir, etc.). The CVD incidence rate was high among PLWH, with risk factors including both conventional CVD risk factors and HCV infection. There is an urgent need for more high-quality research to better understand the effects of HIV progression and drug use. |
| format | Article |
| id | doaj-art-3da9ee4703da463b8c43ca26cfa2b2d8 |
| institution | Kabale University |
| issn | 1876-0341 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
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| series | Journal of Infection and Public Health |
| spelling | doaj-art-3da9ee4703da463b8c43ca26cfa2b2d82025-01-21T04:12:59ZengElsevierJournal of Infection and Public Health1876-03412025-02-01182102654Cardiovascular disease and its risk factors among people living with HIV: A systematic review and meta-analysisMin Du0Shimo Zhang1Min Liu2Jue Liu3Department of Epidemiology and Biostatistics, School of Public Health, Peking University, No.38, Xueyuan Road, Haidian District, Beijing 100191, China; Research Center on HIV/AIDS, School of Public Health, Peking University, No.38, Xueyuan Road, Haidian District, Beijing 100191, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, No.38, Xueyuan Road, Haidian District, Beijing 100191, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, No.38, Xueyuan Road, Haidian District, Beijing 100191, China; Research Center on HIV/AIDS, School of Public Health, Peking University, No.38, Xueyuan Road, Haidian District, Beijing 100191, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, No.38, Xueyuan Road, Haidian District, Beijing 100191, China; Institute for Global Health and Development, Peking University, No.5, Yiheyuan Road, Haidian District, Beijing 100871, China; Global Center for Infectious Disease and Policy Research & Global Health and Infectious Diseases Group, Peking University, No.38, Xueyuan Road, Haidian District, Beijing 100191, China; Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, No.38, Xueyuan Road, Haidian District, Beijing 100191, China; Correspondence to: Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Institute for Global Health and Development, Peking University, Beijing 100191, China.This meta-analysis aimed to quantify the latest cardiovascular disease (CVD) incidence rate and assess the impact of risk factors among people living with HIV (PLWH). We searched PubMed, Embase, Web of Science, Scopus, and the Cochrane Library for studies published up to September 14, 2023. To evaluate effect sizes, we employed multilevel (three-level) random-effects meta-analyses. The pooled incidence rate of CVD was 6.31 per 1000 person-years. Among the 14 risk factors analyzed, the most prevalent was a history of CVD (odds ratio [OR]=3.47), followed by age (per 10-year increase) (OR=1.79), current smoking (OR=1.76), hypertension (OR=1.57), smoking (OR=1.53), diabetes (OR=1.50), previous smoking (OR=1.30), and hepatitis C virus (HCV) infection (OR=1.18). However, there was no statistical significance associated with HIV-specific factors (abacavir use, efavirenz use, and CD4 nadir, etc.). The CVD incidence rate was high among PLWH, with risk factors including both conventional CVD risk factors and HCV infection. There is an urgent need for more high-quality research to better understand the effects of HIV progression and drug use.http://www.sciencedirect.com/science/article/pii/S1876034125000036HIVCardiovascular diseasesRisk factorsMetaMultilevel |
| spellingShingle | Min Du Shimo Zhang Min Liu Jue Liu Cardiovascular disease and its risk factors among people living with HIV: A systematic review and meta-analysis Journal of Infection and Public Health HIV Cardiovascular diseases Risk factors Meta Multilevel |
| title | Cardiovascular disease and its risk factors among people living with HIV: A systematic review and meta-analysis |
| title_full | Cardiovascular disease and its risk factors among people living with HIV: A systematic review and meta-analysis |
| title_fullStr | Cardiovascular disease and its risk factors among people living with HIV: A systematic review and meta-analysis |
| title_full_unstemmed | Cardiovascular disease and its risk factors among people living with HIV: A systematic review and meta-analysis |
| title_short | Cardiovascular disease and its risk factors among people living with HIV: A systematic review and meta-analysis |
| title_sort | cardiovascular disease and its risk factors among people living with hiv a systematic review and meta analysis |
| topic | HIV Cardiovascular diseases Risk factors Meta Multilevel |
| url | http://www.sciencedirect.com/science/article/pii/S1876034125000036 |
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