Curcumin and multiple health outcomes: critical umbrella review of intervention meta-analyses
ObjectiveThis review aimed to determine the therapeutic effects and safety of oral curcumin compared with other comparators for human health and wellbeing outcomes.MethodsPubMed, Embase, and Cochrane Library were searched from their inception to 18 June 2024. The Assessment of Multiple Systematic Re...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1601204/full |
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| author | Qin Xu Hua Lian Rui Zhou Zhenzhen Gu Jiao Wu Yu Wu Zhongyu Li |
| author_facet | Qin Xu Hua Lian Rui Zhou Zhenzhen Gu Jiao Wu Yu Wu Zhongyu Li |
| author_sort | Qin Xu |
| collection | DOAJ |
| description | ObjectiveThis review aimed to determine the therapeutic effects and safety of oral curcumin compared with other comparators for human health and wellbeing outcomes.MethodsPubMed, Embase, and Cochrane Library were searched from their inception to 18 June 2024. The Assessment of Multiple Systematic Reviews-2 checklist, and Grading of Recommendations, Assessment, Development and Evaluation system were used to assess the methodological and evidence quality for each meta-analysis, respectively. The results are presented in a narrative review.ResultsWe included 25 studies. The overall methodological quality was relatively poor, and there is considerable room for improvement. The findings suggest that curcumin has potentially positive effects on lipid profiles, blood pressure, inflammatory markers and oxidative stress, musculoskeletal diseases, emotional and cognitive function, ulcerative colitis, liver and kidney function, primary dysmenorrhea or premenstrual syndrome, rheumatoid arthritis, COVID-19, painful statues, and HR-QOL. However, for many diseases, the conclusions remain uncertain.ConclusionThe available evidence suggests that curcumin is a safe medicinal agent that improves multiple clinical outcomes; however, the scientific quality of published studies needs to be improved. |
| format | Article |
| id | doaj-art-3da86d74c00a4a68a86aee2400c6911b |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-3da86d74c00a4a68a86aee2400c6911b2025-08-20T03:24:47ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-06-011610.3389/fphar.2025.16012041601204Curcumin and multiple health outcomes: critical umbrella review of intervention meta-analysesQin Xu0Hua Lian1Rui Zhou2Zhenzhen Gu3Jiao Wu4Yu Wu5Zhongyu Li6Department of Oncology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaDepartment of Oncology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaDepartment of Oncology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaDepartment of Oncology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaDepartment of Oncology, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, ChinaDepartment of Oncology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaDepartment of Traditional Chinese Medicine Internal Medicine, Eye Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaObjectiveThis review aimed to determine the therapeutic effects and safety of oral curcumin compared with other comparators for human health and wellbeing outcomes.MethodsPubMed, Embase, and Cochrane Library were searched from their inception to 18 June 2024. The Assessment of Multiple Systematic Reviews-2 checklist, and Grading of Recommendations, Assessment, Development and Evaluation system were used to assess the methodological and evidence quality for each meta-analysis, respectively. The results are presented in a narrative review.ResultsWe included 25 studies. The overall methodological quality was relatively poor, and there is considerable room for improvement. The findings suggest that curcumin has potentially positive effects on lipid profiles, blood pressure, inflammatory markers and oxidative stress, musculoskeletal diseases, emotional and cognitive function, ulcerative colitis, liver and kidney function, primary dysmenorrhea or premenstrual syndrome, rheumatoid arthritis, COVID-19, painful statues, and HR-QOL. However, for many diseases, the conclusions remain uncertain.ConclusionThe available evidence suggests that curcumin is a safe medicinal agent that improves multiple clinical outcomes; however, the scientific quality of published studies needs to be improved.https://www.frontiersin.org/articles/10.3389/fphar.2025.1601204/fullcurcuminmetabolic indicatorshealth outcomesevidencemeta-analysisumbrella review |
| spellingShingle | Qin Xu Hua Lian Rui Zhou Zhenzhen Gu Jiao Wu Yu Wu Zhongyu Li Curcumin and multiple health outcomes: critical umbrella review of intervention meta-analyses Frontiers in Pharmacology curcumin metabolic indicators health outcomes evidence meta-analysis umbrella review |
| title | Curcumin and multiple health outcomes: critical umbrella review of intervention meta-analyses |
| title_full | Curcumin and multiple health outcomes: critical umbrella review of intervention meta-analyses |
| title_fullStr | Curcumin and multiple health outcomes: critical umbrella review of intervention meta-analyses |
| title_full_unstemmed | Curcumin and multiple health outcomes: critical umbrella review of intervention meta-analyses |
| title_short | Curcumin and multiple health outcomes: critical umbrella review of intervention meta-analyses |
| title_sort | curcumin and multiple health outcomes critical umbrella review of intervention meta analyses |
| topic | curcumin metabolic indicators health outcomes evidence meta-analysis umbrella review |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1601204/full |
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