Clinico-pathological association of BCL2 in invasive breast carcinoma: A study from tertiary care health centre in Northern India
Background: B-cell lymphoma 2 (Bcl-2) is an antiapoptotic protein and an important clinical breast cancer prognostic marker. The aim of this study was to evaluate the relationship between the BCL2 expression and clinico-pathological parameters in breast cancer. Materials and Methods: Present study i...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-04-01
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| Series: | Indian Journal of Pathology and Microbiology |
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| Online Access: | https://journals.lww.com/10.4103/ijpm.ijpm_259_24 |
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| author | Sarjana Tiwari Kanwalpreet Kaur |
| author_facet | Sarjana Tiwari Kanwalpreet Kaur |
| author_sort | Sarjana Tiwari |
| collection | DOAJ |
| description | Background:
B-cell lymphoma 2 (Bcl-2) is an antiapoptotic protein and an important clinical breast cancer prognostic marker. The aim of this study was to evaluate the relationship between the BCL2 expression and clinico-pathological parameters in breast cancer.
Materials and Methods:
Present study is observational cross-sectional study of 100 biopsy proven cases of breast cancer, and cases with resection specimens were included. IHC analyses for ER, PR, Her2neu, Ki67 and Bcl2 were performed in each case.
Results:
Bcl2 expression was seen in 52% cases. BCL2-positive expression was associated with lower histological grade (0.026), low Ki-67 level (<14%, P < 0.001), hormone receptor positivity (P < 0.001) and luminal breast cancer (P < 0.001) but no association with tumour size, lymphovascular invasion, perineural invasion and TNM stage.
Conclusion:
Expression of Bcl-2, an antiapoptotic protein, is associated with low-grade, slowly proliferating, luminal A-type BC. IHC analysis of Bcl-2 is simple, inexpensive, readily available test to stratify early-stage hormone-positive patients who can be included in clinical trials for Bcl-2 inhibitors. |
| format | Article |
| id | doaj-art-3da70443ad1f4536b9a28f00a9bd0a99 |
| institution | Kabale University |
| issn | 0377-4929 0974-5130 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj-art-3da70443ad1f4536b9a28f00a9bd0a992025-08-20T03:59:26ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49290974-51302025-04-0168232432710.4103/ijpm.ijpm_259_24Clinico-pathological association of BCL2 in invasive breast carcinoma: A study from tertiary care health centre in Northern IndiaSarjana TiwariKanwalpreet KaurBackground: B-cell lymphoma 2 (Bcl-2) is an antiapoptotic protein and an important clinical breast cancer prognostic marker. The aim of this study was to evaluate the relationship between the BCL2 expression and clinico-pathological parameters in breast cancer. Materials and Methods: Present study is observational cross-sectional study of 100 biopsy proven cases of breast cancer, and cases with resection specimens were included. IHC analyses for ER, PR, Her2neu, Ki67 and Bcl2 were performed in each case. Results: Bcl2 expression was seen in 52% cases. BCL2-positive expression was associated with lower histological grade (0.026), low Ki-67 level (<14%, P < 0.001), hormone receptor positivity (P < 0.001) and luminal breast cancer (P < 0.001) but no association with tumour size, lymphovascular invasion, perineural invasion and TNM stage. Conclusion: Expression of Bcl-2, an antiapoptotic protein, is associated with low-grade, slowly proliferating, luminal A-type BC. IHC analysis of Bcl-2 is simple, inexpensive, readily available test to stratify early-stage hormone-positive patients who can be included in clinical trials for Bcl-2 inhibitors.https://journals.lww.com/10.4103/ijpm.ijpm_259_24bcl2 expressionbreast cancermolecular subtypes |
| spellingShingle | Sarjana Tiwari Kanwalpreet Kaur Clinico-pathological association of BCL2 in invasive breast carcinoma: A study from tertiary care health centre in Northern India Indian Journal of Pathology and Microbiology bcl2 expression breast cancer molecular subtypes |
| title | Clinico-pathological association of BCL2 in invasive breast carcinoma: A study from tertiary care health centre in Northern India |
| title_full | Clinico-pathological association of BCL2 in invasive breast carcinoma: A study from tertiary care health centre in Northern India |
| title_fullStr | Clinico-pathological association of BCL2 in invasive breast carcinoma: A study from tertiary care health centre in Northern India |
| title_full_unstemmed | Clinico-pathological association of BCL2 in invasive breast carcinoma: A study from tertiary care health centre in Northern India |
| title_short | Clinico-pathological association of BCL2 in invasive breast carcinoma: A study from tertiary care health centre in Northern India |
| title_sort | clinico pathological association of bcl2 in invasive breast carcinoma a study from tertiary care health centre in northern india |
| topic | bcl2 expression breast cancer molecular subtypes |
| url | https://journals.lww.com/10.4103/ijpm.ijpm_259_24 |
| work_keys_str_mv | AT sarjanatiwari clinicopathologicalassociationofbcl2ininvasivebreastcarcinomaastudyfromtertiarycarehealthcentreinnorthernindia AT kanwalpreetkaur clinicopathologicalassociationofbcl2ininvasivebreastcarcinomaastudyfromtertiarycarehealthcentreinnorthernindia |