Anticancer potential of eugenol in hepatocellular carcinoma through modulation of oxidative stress, inflammation, apoptosis, and proliferation mechanisms

Anticancer potential of eugenol in hepatocellular carcinoma through modulation of oxidative stress, inflammation, apoptosis, and proliferation mechanisms

Abstract This investigation explored the chemopreventive effects of eugenol on diethylnitrosamine (DENA) and acetylaminofluorene (AAF)-induced hepatocellular carcinoma (HCC) in Wistar rats. To induce HCC, DENA was administered intraperitoneally once per week for two weeks at a concentration of 150 m...

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Main Authors: Mohamed Y. Zaky, Hadeer M. Morsy, Adel Abdel-Moneim, Khairy M. A. Zoheir, Anthony Bragoli, Mostafa A. Abdel-Maksoud, Abdulaziz Alamri, Osama M. Ahmed
Format: Article
Language:English
Published: Springer 2025-06-01
Series:Discover Oncology
Subjects:
Hepatocellular carcinoma
Diethylnitrosamine
Acetylaminofluorene
Eugenol
Oxidative stress
Online Access:https://doi.org/10.1007/s12672-025-02243-6
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