Effect of Orlistat Treatment on Visceral Adiposity Index (VAI) in Obese Patients
Introduction: Obesity is a chronic disease characterized by excessive fat accumulation. This study aims to assess the impact of orlistat treatment on the visceral adiposity index and related parameters.Material and Method: This study involved 54 patients (18–65 years, BMI >25) from the intern...
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Sakarya University
2025-06-01
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| Series: | Sakarya Tıp Dergisi |
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| author | İhsan Solmaz Ömer Faruk Alakuş Jehat Kılıç |
| author_facet | İhsan Solmaz Ömer Faruk Alakuş Jehat Kılıç |
| author_sort | İhsan Solmaz |
| collection | DOAJ |
| description | Introduction: Obesity is a chronic disease characterized by excessive fat accumulation. This study aims to assess the impact of orlistat treatment on the visceral adiposity index and related parameters.Material and Method: This study involved 54 patients (18–65 years, BMI >25) from the internal medicine and obesity clinic. Ethical approval and informed consent were obtained. Patients receiving orlistat were monitored at 0, 3, and 6 months. Anthropometric measurements (BMI, weight, waist, and hip circumference) and biochemical markers (glucose, AST, ALT, GGT, TG, HDL) were recorded. VAI was calculated separately for males and females.Results: Clinical and biochemical parameters of 54 patients (F: 52, M: 2) were analyzed. At baseline, mean body weight (103.87±13,01 kg), waist circumference (113.59±10.25 cm), and BMI (41.59±4.86) indicated obesity. Liver enzymes (AST: 20.13 U/L, ALT: 21.87 U/L, GGT: 24.76 U/L) were mostly normal, with slight GGT elevations. Lipid profile showed mean HDL (47.11 mmol/L) and triglycerides (154,89 mg/dL). Over 6 months, significant reductions were observed in weight (93.33±12,44 kg, p<0.01), BMI (37.47±4.61, p<0.01), and waist circumference (105.9±10.2 cm, p<0.01). ALT (p<0.01) and GGT (p<0.001) decreased significantly, while AST did not (p=0.159). HDL improved (p<0.016). VAI slightly decreased (4.42±2.76 to 4.01±2.84), but was not statistically significant (p=0.224). These results suggest weight loss benefits metabolic and liver health.Conclusion: The study observed positive metabolic changes, including weight loss, reduced waist circumference, and decreased BMI. Although VAI showed a decreasing trend after orlistat treatment, the change was not statistically significant. These findings indicate the potential benefits of orlistat. |
| format | Article |
| id | doaj-art-3da2041c8b544e7f963609801cf1ac74 |
| institution | Kabale University |
| issn | 2146-409X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Sakarya University |
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| series | Sakarya Tıp Dergisi |
| spelling | doaj-art-3da2041c8b544e7f963609801cf1ac742025-08-20T03:28:43ZengSakarya UniversitySakarya Tıp Dergisi2146-409X2025-06-0115212813410.31832/smj.164800028Effect of Orlistat Treatment on Visceral Adiposity Index (VAI) in Obese Patientsİhsan Solmaz0https://orcid.org/0000-0002-6624-8063Ömer Faruk Alakuş1https://orcid.org/0000-0003-4039-1256Jehat Kılıç2https://orcid.org/0000-0003-3722-350XSAĞLIK BİLİMLERİ ÜNİVERSİTESİ, DİYARBAKIR GAZİ YAŞARGİL SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİSAĞLIK BİLİMLERİ ÜNİVERSİTESİ, DİYARBAKIR GAZİ YAŞARGİL SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİSAĞLIK BİLİMLERİ ÜNİVERSİTESİ, DİYARBAKIR GAZİ YAŞARGİL SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİIntroduction: Obesity is a chronic disease characterized by excessive fat accumulation. This study aims to assess the impact of orlistat treatment on the visceral adiposity index and related parameters.Material and Method: This study involved 54 patients (18–65 years, BMI >25) from the internal medicine and obesity clinic. Ethical approval and informed consent were obtained. Patients receiving orlistat were monitored at 0, 3, and 6 months. Anthropometric measurements (BMI, weight, waist, and hip circumference) and biochemical markers (glucose, AST, ALT, GGT, TG, HDL) were recorded. VAI was calculated separately for males and females.Results: Clinical and biochemical parameters of 54 patients (F: 52, M: 2) were analyzed. At baseline, mean body weight (103.87±13,01 kg), waist circumference (113.59±10.25 cm), and BMI (41.59±4.86) indicated obesity. Liver enzymes (AST: 20.13 U/L, ALT: 21.87 U/L, GGT: 24.76 U/L) were mostly normal, with slight GGT elevations. Lipid profile showed mean HDL (47.11 mmol/L) and triglycerides (154,89 mg/dL). Over 6 months, significant reductions were observed in weight (93.33±12,44 kg, p<0.01), BMI (37.47±4.61, p<0.01), and waist circumference (105.9±10.2 cm, p<0.01). ALT (p<0.01) and GGT (p<0.001) decreased significantly, while AST did not (p=0.159). HDL improved (p<0.016). VAI slightly decreased (4.42±2.76 to 4.01±2.84), but was not statistically significant (p=0.224). These results suggest weight loss benefits metabolic and liver health.Conclusion: The study observed positive metabolic changes, including weight loss, reduced waist circumference, and decreased BMI. Although VAI showed a decreasing trend after orlistat treatment, the change was not statistically significant. These findings indicate the potential benefits of orlistat.https://dergipark.org.tr/tr/download/article-file/4646161obesityorlistatvisceral adiposity index |
| spellingShingle | İhsan Solmaz Ömer Faruk Alakuş Jehat Kılıç Effect of Orlistat Treatment on Visceral Adiposity Index (VAI) in Obese Patients Sakarya Tıp Dergisi obesity orlistat visceral adiposity index |
| title | Effect of Orlistat Treatment on Visceral Adiposity Index (VAI) in Obese Patients |
| title_full | Effect of Orlistat Treatment on Visceral Adiposity Index (VAI) in Obese Patients |
| title_fullStr | Effect of Orlistat Treatment on Visceral Adiposity Index (VAI) in Obese Patients |
| title_full_unstemmed | Effect of Orlistat Treatment on Visceral Adiposity Index (VAI) in Obese Patients |
| title_short | Effect of Orlistat Treatment on Visceral Adiposity Index (VAI) in Obese Patients |
| title_sort | effect of orlistat treatment on visceral adiposity index vai in obese patients |
| topic | obesity orlistat visceral adiposity index |
| url | https://dergipark.org.tr/tr/download/article-file/4646161 |
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