Mebendazole Exerts Anticancer Activity in Ovarian Cancer Cell Lines via Novel Girdin-Mediated AKT/IKKα/β/NF-κB Signaling Axis

Mebendazole Exerts Anticancer Activity in Ovarian Cancer Cell Lines via Novel Girdin-Mediated AKT/IKKα/β/NF-κB Signaling Axis

Mebendazole (MBZ), a benzimidazole anthelmintic and cytoskeleton-disrupting compound, exhibits antitumor properties; however, its action on ovarian cancer (OC) is not clearly understood. This study evaluates the effect of MBZ on OC cell lines OVCAR3 and OAW42, focusing on cell proliferation, migrati...

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Bibliographic Details
Main Authors: Rahul Gupta, Dipanjan Roy, Arijit Ghosh, Yasmin Begum, Dipanjan Ghosh, Snehasikta Swarnakar
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Cells
Subjects:
mebendazole
girdin
MMP-9
EMT
ovarian cancer
metastasis
Online Access:https://www.mdpi.com/2073-4409/14/2/113
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