IFITM3 restricts influenza A virus entry by blocking the formation of fusion pores following virus-endosome hemifusion.

IFITM3 restricts influenza A virus entry by blocking the formation of fusion pores following virus-endosome hemifusion.

Interferon-induced transmembrane proteins (IFITMs) inhibit infection of diverse enveloped viruses, including the influenza A virus (IAV) which is thought to enter from late endosomes. Recent evidence suggests that IFITMs block virus hemifusion (lipid mixing in the absence of viral content release) b...

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Bibliographic Details
Main Authors: Tanay M Desai, Mariana Marin, Christopher R Chin, George Savidis, Abraham L Brass, Gregory B Melikyan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-04-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004048&type=printable
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