Store-Operated Ca Entry in Fibrosis and Tissue Remodeling
Fibrosis is a pathological condition characterized by excessive tissue deposition of extracellular matrix (ECM) components, leading to scarring and impaired function across multiple organ systems. This complex process is mediated by a dynamic interplay between cell types, including myofibroblasts, f...
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SAGE Publishing
2024-11-01
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| Online Access: | https://doi.org/10.1177/25152564241291374 |
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| author | Ahmed Emam Abdelnaby Mohamed Trebak |
| author_facet | Ahmed Emam Abdelnaby Mohamed Trebak |
| author_sort | Ahmed Emam Abdelnaby |
| collection | DOAJ |
| description | Fibrosis is a pathological condition characterized by excessive tissue deposition of extracellular matrix (ECM) components, leading to scarring and impaired function across multiple organ systems. This complex process is mediated by a dynamic interplay between cell types, including myofibroblasts, fibroblasts, immune cells, epithelial cells, and endothelial cells, each contributing distinctively through various signaling pathways. Critical to the regulatory mechanisms involved in fibrosis is store-operated calcium entry (SOCE), a calcium entry pathway into the cytosol active at the endoplasmic reticulum-plasma membrane contact sites and common to all cells. This review addresses the multifactorial nature of fibrosis with a focus on the pivotal roles of different cell types. We highlight the essential functions of myofibroblasts in ECM production, the transformation of fibroblasts, and the participation of immune cells in modulating the fibrotic landscape. We emphasize the contributions of SOCE in these different cell types to fibrosis, by exploring the involvement of SOCE in cellular functions such as proliferation, migration, secretion, and inflammatory responses. The examination of the cellular and molecular mechanisms of fibrosis and the role of SOCE in these mechanisms offers the potential of targeting SOCE as a therapeutic strategy for mitigating or reversing fibrosis. |
| format | Article |
| id | doaj-art-3d94f2101ec74bbdb5b6ff1534638a30 |
| institution | DOAJ |
| issn | 2515-2564 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
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| spelling | doaj-art-3d94f2101ec74bbdb5b6ff1534638a302025-08-20T03:08:01ZengSAGE PublishingContact2515-25642024-11-01710.1177/25152564241291374Store-Operated Ca Entry in Fibrosis and Tissue RemodelingAhmed Emam Abdelnaby0Mohamed Trebak1 UPMC Hillman Cancer Center, , Pittsburgh, Pennsylvania, USA UPMC Hillman Cancer Center, , Pittsburgh, Pennsylvania, USAFibrosis is a pathological condition characterized by excessive tissue deposition of extracellular matrix (ECM) components, leading to scarring and impaired function across multiple organ systems. This complex process is mediated by a dynamic interplay between cell types, including myofibroblasts, fibroblasts, immune cells, epithelial cells, and endothelial cells, each contributing distinctively through various signaling pathways. Critical to the regulatory mechanisms involved in fibrosis is store-operated calcium entry (SOCE), a calcium entry pathway into the cytosol active at the endoplasmic reticulum-plasma membrane contact sites and common to all cells. This review addresses the multifactorial nature of fibrosis with a focus on the pivotal roles of different cell types. We highlight the essential functions of myofibroblasts in ECM production, the transformation of fibroblasts, and the participation of immune cells in modulating the fibrotic landscape. We emphasize the contributions of SOCE in these different cell types to fibrosis, by exploring the involvement of SOCE in cellular functions such as proliferation, migration, secretion, and inflammatory responses. The examination of the cellular and molecular mechanisms of fibrosis and the role of SOCE in these mechanisms offers the potential of targeting SOCE as a therapeutic strategy for mitigating or reversing fibrosis.https://doi.org/10.1177/25152564241291374 |
| spellingShingle | Ahmed Emam Abdelnaby Mohamed Trebak Store-Operated Ca Entry in Fibrosis and Tissue Remodeling Contact |
| title | Store-Operated Ca Entry in Fibrosis and Tissue Remodeling |
| title_full | Store-Operated Ca Entry in Fibrosis and Tissue Remodeling |
| title_fullStr | Store-Operated Ca Entry in Fibrosis and Tissue Remodeling |
| title_full_unstemmed | Store-Operated Ca Entry in Fibrosis and Tissue Remodeling |
| title_short | Store-Operated Ca Entry in Fibrosis and Tissue Remodeling |
| title_sort | store operated ca entry in fibrosis and tissue remodeling |
| url | https://doi.org/10.1177/25152564241291374 |
| work_keys_str_mv | AT ahmedemamabdelnaby storeoperatedcaentryinfibrosisandtissueremodeling AT mohamedtrebak storeoperatedcaentryinfibrosisandtissueremodeling |