Association of Helicobacter pylori related chronic atrophic gastritis and gastric cancer risk: a literature review
Chronic atrophic gastritis (CAG) is considered to be closely related to Helicobacter pylori (H. pylori) infection and characterized by the atrophy and/or intestinal metaplasia (IM) of the gastric mucosa in pathology. CAG is often regarded as the precancerous lesion of gastric cancer and H. pylori in...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1504749/full |
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| author | Zefeng Zhang Sitong Chen Shudan Li Yadan Zheng Lifei Mai Xiaoguang Zhang |
| author_facet | Zefeng Zhang Sitong Chen Shudan Li Yadan Zheng Lifei Mai Xiaoguang Zhang |
| author_sort | Zefeng Zhang |
| collection | DOAJ |
| description | Chronic atrophic gastritis (CAG) is considered to be closely related to Helicobacter pylori (H. pylori) infection and characterized by the atrophy and/or intestinal metaplasia (IM) of the gastric mucosa in pathology. CAG is often regarded as the precancerous lesion of gastric cancer and H. pylori infection stimulates the development of atrophy and IM and the progression of gastric cancer through the persistent effect acting on the gastric mucosa, including releasing inflammatory factors such as Interleukin-8(IL-8). From the molecular biology perspective, growing evidence shows that H. pylori probably induce the expression of NF-κB, miR-204, miR-27a, hnRNPA2B1, and JARID1B, which play crucial roles in the progression of CAG into gastric cancer. In addition, H. pylori can increase Epstein-Barr virus (EBV) infection, and the co-infection will jointly increase gastric cancer risk. Furthermore, H. pylori induces cellular senescence and promotes atrophy progression and finally increases the gastric cancer risk. This review aims to explore the carcinogenic mechanisms of H. pylori related CAG in order to provide theoretical foundations for the pathogenesis mechanism and early detection and prevention of gastric cancer. |
| format | Article |
| id | doaj-art-3d854b0f039d4e10a2dd8fa13047e7fa |
| institution | OA Journals |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-3d854b0f039d4e10a2dd8fa13047e7fa2025-08-20T01:49:28ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-02-011210.3389/fmed.2025.15047491504749Association of Helicobacter pylori related chronic atrophic gastritis and gastric cancer risk: a literature reviewZefeng Zhang0Sitong Chen1Shudan Li2Yadan Zheng3Lifei Mai4Xiaoguang Zhang5Department of Digestive Endoscopy Center, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, ChinaSouthern Medical University, Guangzhou, Guangdong, ChinaSouthern Medical University, Guangzhou, Guangdong, ChinaSouthern Medical University, Guangzhou, Guangdong, ChinaSouthern Medical University, Guangzhou, Guangdong, ChinaDepartment of Digestive Endoscopy Center, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, ChinaChronic atrophic gastritis (CAG) is considered to be closely related to Helicobacter pylori (H. pylori) infection and characterized by the atrophy and/or intestinal metaplasia (IM) of the gastric mucosa in pathology. CAG is often regarded as the precancerous lesion of gastric cancer and H. pylori infection stimulates the development of atrophy and IM and the progression of gastric cancer through the persistent effect acting on the gastric mucosa, including releasing inflammatory factors such as Interleukin-8(IL-8). From the molecular biology perspective, growing evidence shows that H. pylori probably induce the expression of NF-κB, miR-204, miR-27a, hnRNPA2B1, and JARID1B, which play crucial roles in the progression of CAG into gastric cancer. In addition, H. pylori can increase Epstein-Barr virus (EBV) infection, and the co-infection will jointly increase gastric cancer risk. Furthermore, H. pylori induces cellular senescence and promotes atrophy progression and finally increases the gastric cancer risk. This review aims to explore the carcinogenic mechanisms of H. pylori related CAG in order to provide theoretical foundations for the pathogenesis mechanism and early detection and prevention of gastric cancer.https://www.frontiersin.org/articles/10.3389/fmed.2025.1504749/fullchronic atrophic gastritisgastric cancer riskprecancerous lesionHelicobacter pyloriintestinal metaplasia |
| spellingShingle | Zefeng Zhang Sitong Chen Shudan Li Yadan Zheng Lifei Mai Xiaoguang Zhang Association of Helicobacter pylori related chronic atrophic gastritis and gastric cancer risk: a literature review Frontiers in Medicine chronic atrophic gastritis gastric cancer risk precancerous lesion Helicobacter pylori intestinal metaplasia |
| title | Association of Helicobacter pylori related chronic atrophic gastritis and gastric cancer risk: a literature review |
| title_full | Association of Helicobacter pylori related chronic atrophic gastritis and gastric cancer risk: a literature review |
| title_fullStr | Association of Helicobacter pylori related chronic atrophic gastritis and gastric cancer risk: a literature review |
| title_full_unstemmed | Association of Helicobacter pylori related chronic atrophic gastritis and gastric cancer risk: a literature review |
| title_short | Association of Helicobacter pylori related chronic atrophic gastritis and gastric cancer risk: a literature review |
| title_sort | association of helicobacter pylori related chronic atrophic gastritis and gastric cancer risk a literature review |
| topic | chronic atrophic gastritis gastric cancer risk precancerous lesion Helicobacter pylori intestinal metaplasia |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1504749/full |
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