In vitro evaluation of curcumin's antisickling activity and in silico analysis of curcuminoids and their ADMET properties

In vitro evaluation of curcumin's antisickling activity and in silico analysis of curcuminoids and their ADMET properties

Abstract Background The aim of this study was to demonstrate the antisickling activity of curcumin and the in silico potential of curcuminoids and curcumin metabolites to inhibit HbS polymerization. Methods Emmel, osmotic, thermal fragility and F2+/Fe3+ ratio tests were carried out to display the an...

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Bibliographic Details
Main Authors: Clément M. Mbadiko, Koto-te-Nyiwa Ngbolua, Gédéon N. Bongo, Aristote P. Matondo, Jason T. Kilembe, Damien S. T. Tshibangu, Dorothée D. Tshilanda, Nadège K. Ngombe, Théophile F. Mbemba, Pius T. Mpiana
Format: Article
Language:English
Published: Springer 2025-05-01
Series:Discover Chemistry
Subjects:
Sickle cell disease
Bioactivity
Curcuma longa
Curcumin
Molecular docking
ADMET
Online Access:https://doi.org/10.1007/s44371-025-00171-6
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