Cross-National comparison of antiepileptic drug use: Catalonia, Denmark and Norway, 2007-2011
<p>Background: Antiepileptic drug (AED)consumption has increased in recent years mainly from those AEDs marketed since 1990. The purpose is to describe and compare AED consumption in Catalonia, Denmark and Norway.</p><p>Methods: Population-based descriptive study set in the outpat...
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| Format: | Article |
| Language: | English |
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Milano University Press
2014-07-01
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| Series: | Epidemiology, Biostatistics and Public Health |
| Online Access: | http://ebph.it/article/view/9405 |
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| author | Pili Ferrer-Argeles Concita Rafaniello Mònica Sabaté Elena Ballarín Anna Coma Corinne Zara Annalisa Capuano Francesco Rossi Joan-Ramon Laporte Luisa Ibáñez |
| author_facet | Pili Ferrer-Argeles Concita Rafaniello Mònica Sabaté Elena Ballarín Anna Coma Corinne Zara Annalisa Capuano Francesco Rossi Joan-Ramon Laporte Luisa Ibáñez |
| author_sort | Pili Ferrer-Argeles |
| collection | DOAJ |
| description | <p>Background: Antiepileptic drug (AED)consumption has increased in recent years mainly from those AEDs marketed since 1990. The purpose is to describe and compare AED consumption in Catalonia, Denmark and Norway.</p><p>Methods: Population-based descriptive study set in the outpatient healthcare sector. Data were retrieved from the Norwegian Prescription Register, Danish Register of Medicinal Product Statistics and DATAMART<sup>®</sup> in Catalonia, for 2007-2011.</p><p>We calculated defined daily doses/1000 inhabitants/day (DID), by age and gender. AEDs were defined according to the Anatomical Therapeutic Chemical classification (N03A). We reviewed the population covered by the databases, the drug data source and the definition of outpatient healthcare sector to compare the results across the three settings.</p><p>Results: Total AED use steadily increased over the study period in the three settings. In 2011, consumption was highest in Catalonia (15.20 DID), followed by Denmark (15.06 DID) and Norway (14.24 DID). The “other AEDs” (N03AX) subgroup represented 60% of all AED use. The N03A pattern by gender did not differ across the three settings. Marked differences by age and gender appeared when studying lamotrigine, topiramate, gabapentin, pregabalin and levetiracetam. Differences among the databases were mainly in the definition of outpatient healthcare setting.</p>Conclusions: There was a rapid increase in “other AEDs” in all three settings. Although we did not have information on the indication for the use of AEDs, the drug data source, population coverage of the database and definition of the healthcare setting helped us interpret the results. |
| format | Article |
| id | doaj-art-3d83e3ebe15c409eb2314c65ba8cdcae |
| institution | OA Journals |
| issn | 2282-0930 |
| language | English |
| publishDate | 2014-07-01 |
| publisher | Milano University Press |
| record_format | Article |
| series | Epidemiology, Biostatistics and Public Health |
| spelling | doaj-art-3d83e3ebe15c409eb2314c65ba8cdcae2025-08-20T01:55:05ZengMilano University PressEpidemiology, Biostatistics and Public Health2282-09302014-07-0111310.2427/94059513Cross-National comparison of antiepileptic drug use: Catalonia, Denmark and Norway, 2007-2011Pili Ferrer-Argeles0Concita Rafaniello1Mònica Sabaté2Elena Ballarín3Anna Coma4Corinne Zara5Annalisa Capuano6Francesco Rossi7Joan-Ramon Laporte8Luisa Ibáñez9Fundació Institut Català de FarmacologiaDepartment of Experimental Medicine, Section of Pharmacology “Leonardo Donatelli”, Centre of Pharmacosurveillance and Pharmacoepidemiology, Faculty of Medicine and Surgery, Second University of Naples, Naples, Italy.Fundació Institut Català de Farmacologia. Servei de Farmacologia, Hospital Universitari Vall d’Hebron Departament de Farmacologia, Terapèutica i Toxicologia, Universitat Autònoma de Barcelona. Pg. Vall d’Hebron 119-129 Barcelona 08035 SpainFundació Institut Català de Farmacologia. Servei de Farmacologia, Hospital Universitari Vall d’Hebron Departament de Farmacologia, Terapèutica i Toxicologia, Universitat Autònoma de Barcelona. Pg. Vall d’Hebron 119-129 Barcelona 08029 (Spain)Pharmacy Department. Barcelona Health Region. Catalan Health Service. Mestral Building. Parc Sanitari Pere Virgili. Esteve Terrades 30 Barcelona 08023 SpainPharmacy Department. Barcelona Health Region. Catalan Health Service. Mestral Building. Parc Sanitari Pere Virgili. Esteve Terrades 30 Barcelona 08023 SpainDepartment of Experimental Medicine, Section of Pharmacology “Leonardo Donatelli”, Centre of Pharmacosurveillance and Pharmacoepidemiology, Faculty of Medicine and Surgery, Second University of Naples, Naples, Italy. Via S.Maria di Costantinopoli, 16 80138 Naples ItalyDepartment of Experimental Medicine, Section of Pharmacology “Leonardo Donatelli”, Centre of Pharmacosurveillance and Pharmacoepidemiology, Faculty of Medicine and Surgery, Second University of Naples, Naples, Italy. Via S.Maria di Costantinopoli, 16 80138 Naples ItalyFundació Institut Català de Farmacologia. Servei de Farmacologia, Hospital Universitari Vall d’Hebron Departament de Farmacologia, Terapèutica i Toxicologia, Universitat Autònoma de Barcelona. Pg. Vall d’Hebron 119-129 Barcelona 08035 SpainFundació Institut Català de Farmacologia. Servei de Farmacologia, Hospital Universitari Vall d’Hebron Departament de Farmacologia, Terapèutica i Toxicologia, Universitat Autònoma de Barcelona. Pg. Vall d’Hebron 119-129 Barcelona 08035 Spain<p>Background: Antiepileptic drug (AED)consumption has increased in recent years mainly from those AEDs marketed since 1990. The purpose is to describe and compare AED consumption in Catalonia, Denmark and Norway.</p><p>Methods: Population-based descriptive study set in the outpatient healthcare sector. Data were retrieved from the Norwegian Prescription Register, Danish Register of Medicinal Product Statistics and DATAMART<sup>®</sup> in Catalonia, for 2007-2011.</p><p>We calculated defined daily doses/1000 inhabitants/day (DID), by age and gender. AEDs were defined according to the Anatomical Therapeutic Chemical classification (N03A). We reviewed the population covered by the databases, the drug data source and the definition of outpatient healthcare sector to compare the results across the three settings.</p><p>Results: Total AED use steadily increased over the study period in the three settings. In 2011, consumption was highest in Catalonia (15.20 DID), followed by Denmark (15.06 DID) and Norway (14.24 DID). The “other AEDs” (N03AX) subgroup represented 60% of all AED use. The N03A pattern by gender did not differ across the three settings. Marked differences by age and gender appeared when studying lamotrigine, topiramate, gabapentin, pregabalin and levetiracetam. Differences among the databases were mainly in the definition of outpatient healthcare setting.</p>Conclusions: There was a rapid increase in “other AEDs” in all three settings. Although we did not have information on the indication for the use of AEDs, the drug data source, population coverage of the database and definition of the healthcare setting helped us interpret the results.http://ebph.it/article/view/9405 |
| spellingShingle | Pili Ferrer-Argeles Concita Rafaniello Mònica Sabaté Elena Ballarín Anna Coma Corinne Zara Annalisa Capuano Francesco Rossi Joan-Ramon Laporte Luisa Ibáñez Cross-National comparison of antiepileptic drug use: Catalonia, Denmark and Norway, 2007-2011 Epidemiology, Biostatistics and Public Health |
| title | Cross-National comparison of antiepileptic drug use: Catalonia, Denmark and Norway, 2007-2011 |
| title_full | Cross-National comparison of antiepileptic drug use: Catalonia, Denmark and Norway, 2007-2011 |
| title_fullStr | Cross-National comparison of antiepileptic drug use: Catalonia, Denmark and Norway, 2007-2011 |
| title_full_unstemmed | Cross-National comparison of antiepileptic drug use: Catalonia, Denmark and Norway, 2007-2011 |
| title_short | Cross-National comparison of antiepileptic drug use: Catalonia, Denmark and Norway, 2007-2011 |
| title_sort | cross national comparison of antiepileptic drug use catalonia denmark and norway 2007 2011 |
| url | http://ebph.it/article/view/9405 |
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