Go-6976 reverses hyperglycemia-induced insulin resistance independently of cPKC inhibition in adipocytes.
Chronic hyperglycemia induces insulin resistance by mechanisms that are incompletely understood. One model of hyperglycemia-induced insulin resistance involves chronic preincubation of adipocytes in the presence of high glucose and low insulin concentrations. We have previously shown that the mTOR c...
Saved in:
| Main Authors: | Katherine A Robinson, Krisztina Hegyi, Yusuf A Hannun, Maria G Buse, Jaswinder K Sethi |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0108963 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Biased signaling by mutant EGFR underlies dependence on PKCα in lung adenocarcinoma
by: Mojtaba Sadeghi, et al.
Published: (2024-12-01) -
Regulation of insulin sensitivity in adipocytes by ZFYVE28
by: Luo Xin, et al.
Published: (2025-01-01) -
Molecules secreted by visceral adipocytes in patients with coronary atherosclerosis and insulin resistance
by: S. R. Ledovskikh, et al.
Published: (2024-10-01) -
Adipocyte-Specific Deletion of Histon Deacetylase 9 Reduces Adiposity but Triggers Glucose Intolerance, Hyperglycemia, and Hyperlipidemia in Male Obese Mice
by: Jaeeun Lee, et al.
Published: (2025-05-01) -
Role of PKC and CaV1.2 in detrusor overactivity in a model of obesity associated with insulin resistance in mice.
by: Luiz O Leiria, et al.
Published: (2012-01-01)