Highly Oriented Bio‐Mimetic Hydrogels by Calendering
Abstract Anisotropic hydrogels are promising candidates as load‐bearing materials for tissue engineering, while huge challenges remain in exploring effective and scalable methods for the preparation of anisotropic hydrogels with simultaneous high tensile strength, large toughness, good fracture stra...
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| Format: | Article |
| Language: | English |
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Wiley
2025-08-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202504778 |
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| author | Zhanqi Liu Yuqing Wang Haidi Wu Huamin Li Longcheng Tang Guo Wang Daxin Zhang Jianping Yin Yinggang Miao Yongqian Shi Pingan Song An Xie Xuewu Huang Wancheng Gu Yiu Wing Mai Jiefeng Gao |
| author_facet | Zhanqi Liu Yuqing Wang Haidi Wu Huamin Li Longcheng Tang Guo Wang Daxin Zhang Jianping Yin Yinggang Miao Yongqian Shi Pingan Song An Xie Xuewu Huang Wancheng Gu Yiu Wing Mai Jiefeng Gao |
| author_sort | Zhanqi Liu |
| collection | DOAJ |
| description | Abstract Anisotropic hydrogels are promising candidates as load‐bearing materials for tissue engineering, while huge challenges remain in exploring effective and scalable methods for the preparation of anisotropic hydrogels with simultaneous high tensile strength, large toughness, good fracture strain, excellent fatigue and swelling resistances. Inspired by the brick‐and‐mortar layered structure of nacre and the hierarchical fibril strucure of soft tissues (e.g., tendon and ligament), a facile organogel‐assissted calendering strategy is reported to design anisotropic hydrogels with a highly oriented and dense fiber lamellar strucure. The synergy of shearing and annealing promotes macromolecular chain alignment and crystallinity along the calendering direction while forming a nacre‐like lamellar morphology in the thickness direction. The tensile strength, elastic modulus, toughness and fracture energy of the anisotropic hydrogels can reach as high as 41.0 ± 6.4 MPa, 67.0 ± 5.1 MPa, 46.2 ± 3.3 MJ m−3, and 62.20 ± 8.55 kJ m−2, respectively. More importantly, the hydrogels show excellent crack growth and swelling resistances with the fatigue threshold increased to 2170 J m−2. This study provides a promising approach for fabrication of large‐sized biomimetic anisotropic hydrogels with outstanding mechanical properties for biomedical and engineering applications. |
| format | Article |
| id | doaj-art-3d825befa92743daba82fe5b8d3a5feb |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-3d825befa92743daba82fe5b8d3a5feb2025-08-20T11:56:10ZengWileyAdvanced Science2198-38442025-08-011230n/an/a10.1002/advs.202504778Highly Oriented Bio‐Mimetic Hydrogels by CalenderingZhanqi Liu0Yuqing Wang1Haidi Wu2Huamin Li3Longcheng Tang4Guo Wang5Daxin Zhang6Jianping Yin7Yinggang Miao8Yongqian Shi9Pingan Song10An Xie11Xuewu Huang12Wancheng Gu13Yiu Wing Mai14Jiefeng Gao15School of Chemistry and Chemical Engineering Yangzhou University No 180, Road Siwangting Yangzhou Jiangsu 225002 ChinaSchool of Chemistry and Chemical Engineering Yangzhou University No 180, Road Siwangting Yangzhou Jiangsu 225002 ChinaSchool of Chemistry and Chemical Engineering Yangzhou University No 180, Road Siwangting Yangzhou Jiangsu 225002 ChinaSchool of Chemistry and Chemical Engineering Yangzhou University No 180, Road Siwangting Yangzhou Jiangsu 225002 ChinaKey Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education College of Material Chemistry and Chemical Engineering Hangzhou Normal University Hangzhou 311121 ChinaShanxi Key Laboratory of Impact Dynamics and its Engineering Application School of Aeronautics Northwestern Polytechnical University Xi'an 710072 ChinaShanxi Key Laboratory of Impact Dynamics and its Engineering Application School of Aeronautics Northwestern Polytechnical University Xi'an 710072 ChinaShanxi Key Laboratory of Impact Dynamics and its Engineering Application School of Aeronautics Northwestern Polytechnical University Xi'an 710072 ChinaShanxi Key Laboratory of Impact Dynamics and its Engineering Application School of Aeronautics Northwestern Polytechnical University Xi'an 710072 ChinaCollege of Environment and Safety Engineering Fuzhou University Fuzhou 350116 ChinaCentre for Future Materials University of Southern Queensland Springfield Campus Southern Queensland QLD 4300 AustraliaSchool of Chemistry and Chemical Engineering Yangzhou University No 180, Road Siwangting Yangzhou Jiangsu 225002 ChinaTesting Center Yangzhou University Yangzhou Jiangsu 225002 ChinaSchool of Chemistry and Chemical Engineering Yangzhou University No 180, Road Siwangting Yangzhou Jiangsu 225002 ChinaDepartment of Mechanical Engineering The Hong Kong Polytechnic University Hung Hom, Kowloon Hong Kong 999077 ChinaSchool of Chemistry and Chemical Engineering Yangzhou University No 180, Road Siwangting Yangzhou Jiangsu 225002 ChinaAbstract Anisotropic hydrogels are promising candidates as load‐bearing materials for tissue engineering, while huge challenges remain in exploring effective and scalable methods for the preparation of anisotropic hydrogels with simultaneous high tensile strength, large toughness, good fracture strain, excellent fatigue and swelling resistances. Inspired by the brick‐and‐mortar layered structure of nacre and the hierarchical fibril strucure of soft tissues (e.g., tendon and ligament), a facile organogel‐assissted calendering strategy is reported to design anisotropic hydrogels with a highly oriented and dense fiber lamellar strucure. The synergy of shearing and annealing promotes macromolecular chain alignment and crystallinity along the calendering direction while forming a nacre‐like lamellar morphology in the thickness direction. The tensile strength, elastic modulus, toughness and fracture energy of the anisotropic hydrogels can reach as high as 41.0 ± 6.4 MPa, 67.0 ± 5.1 MPa, 46.2 ± 3.3 MJ m−3, and 62.20 ± 8.55 kJ m−2, respectively. More importantly, the hydrogels show excellent crack growth and swelling resistances with the fatigue threshold increased to 2170 J m−2. This study provides a promising approach for fabrication of large‐sized biomimetic anisotropic hydrogels with outstanding mechanical properties for biomedical and engineering applications.https://doi.org/10.1002/advs.202504778anisotropic hydrogelscalenderingfatigue resistancemechanical properties |
| spellingShingle | Zhanqi Liu Yuqing Wang Haidi Wu Huamin Li Longcheng Tang Guo Wang Daxin Zhang Jianping Yin Yinggang Miao Yongqian Shi Pingan Song An Xie Xuewu Huang Wancheng Gu Yiu Wing Mai Jiefeng Gao Highly Oriented Bio‐Mimetic Hydrogels by Calendering Advanced Science anisotropic hydrogels calendering fatigue resistance mechanical properties |
| title | Highly Oriented Bio‐Mimetic Hydrogels by Calendering |
| title_full | Highly Oriented Bio‐Mimetic Hydrogels by Calendering |
| title_fullStr | Highly Oriented Bio‐Mimetic Hydrogels by Calendering |
| title_full_unstemmed | Highly Oriented Bio‐Mimetic Hydrogels by Calendering |
| title_short | Highly Oriented Bio‐Mimetic Hydrogels by Calendering |
| title_sort | highly oriented bio mimetic hydrogels by calendering |
| topic | anisotropic hydrogels calendering fatigue resistance mechanical properties |
| url | https://doi.org/10.1002/advs.202504778 |
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