Expression and relationship of PD-L1, CD24, and CD47 in hepatitis B virus associated hepatocellular carcinoma
Abstract Immune checkpoint inhibitor (ICI) therapy is the new standard treatment for advanced or metastatic hepatocellular carcinoma (HCC); however, many patients still fail to respond. This study explored the expression and prognosis of programmed death ligand 1 (PD-L1), cluster of differentiation...
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Nature Portfolio
2024-12-01
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| Online Access: | https://doi.org/10.1038/s41598-024-83145-5 |
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| author | Aiping Lin Mingxia Wang Zhihui Wang Juan Lin Zhihui Lin Shaowei Lin Shiyun Lu Hong Lin Haijun Tang Xueping Huang |
| author_facet | Aiping Lin Mingxia Wang Zhihui Wang Juan Lin Zhihui Lin Shaowei Lin Shiyun Lu Hong Lin Haijun Tang Xueping Huang |
| author_sort | Aiping Lin |
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| description | Abstract Immune checkpoint inhibitor (ICI) therapy is the new standard treatment for advanced or metastatic hepatocellular carcinoma (HCC); however, many patients still fail to respond. This study explored the expression and prognosis of programmed death ligand 1 (PD-L1), cluster of differentiation 24 (CD24), and cluster of differentiation 47 (CD47) in patients with hepatitis B virus-associated HCC (HBV-associated HCC). We analyzed sequencing data from the Cancer Genome Atlas (TCGA) and investigated the expression of PD-L1, CD24, and CD47 in HBV-associated HCC patients by immunohistochemistry and their relationship with prognosis and clinicopathological factors. HCC data from the TCGA database show that PD-L1 was substantially correlated with various immune cells. In 67 patients with HBV-associated HCC, high PD-L1 and CD24 expression levels were related to poor overall survival (OS) and progression-free survival (PFS). PD-L1 expression was significantly associated with the staging of HBV-associated HCC (p = 0.011) and Ki67 expression (p = 0.024). Correlation analysis between variables reveals that PD-L1 was significantly positively correlated with CD24 and CD47. High expression of PD-L1 and CD24 are risk factors for poor prognosis in HBV-associated HCC patients following curative resection. PD-L1 is significantly correlated with CD24 and CD47. |
| format | Article |
| id | doaj-art-3d7fa44cf09e495cb6c277beaf7f4e3b |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-3d7fa44cf09e495cb6c277beaf7f4e3b2024-12-29T12:16:49ZengNature PortfolioScientific Reports2045-23222024-12-0114111110.1038/s41598-024-83145-5Expression and relationship of PD-L1, CD24, and CD47 in hepatitis B virus associated hepatocellular carcinomaAiping Lin0Mingxia Wang1Zhihui Wang2Juan Lin3Zhihui Lin4Shaowei Lin5Shiyun Lu6Hong Lin7Haijun Tang8Xueping Huang9Department of Gastroenterology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial HospitalDepartment of Hepatology, Mengchao Hepatobiliary Hospital of Fujian Medical UniversityDepartment of Thoracic Oncology, Fifth Affiliated Hospital of Sun Yat-sen UniversityDepartment of Pathology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial HospitalDepartment of Gastroenterology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial HospitalSchool of Public Health, Fujian Medical UniversityDepartment of Gastroenterology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial HospitalDepartment of Gastroenterology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial HospitalCenter for Experimental Research in Clinical Medicine, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial HospitalDepartment of Gastroenterology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial HospitalAbstract Immune checkpoint inhibitor (ICI) therapy is the new standard treatment for advanced or metastatic hepatocellular carcinoma (HCC); however, many patients still fail to respond. This study explored the expression and prognosis of programmed death ligand 1 (PD-L1), cluster of differentiation 24 (CD24), and cluster of differentiation 47 (CD47) in patients with hepatitis B virus-associated HCC (HBV-associated HCC). We analyzed sequencing data from the Cancer Genome Atlas (TCGA) and investigated the expression of PD-L1, CD24, and CD47 in HBV-associated HCC patients by immunohistochemistry and their relationship with prognosis and clinicopathological factors. HCC data from the TCGA database show that PD-L1 was substantially correlated with various immune cells. In 67 patients with HBV-associated HCC, high PD-L1 and CD24 expression levels were related to poor overall survival (OS) and progression-free survival (PFS). PD-L1 expression was significantly associated with the staging of HBV-associated HCC (p = 0.011) and Ki67 expression (p = 0.024). Correlation analysis between variables reveals that PD-L1 was significantly positively correlated with CD24 and CD47. High expression of PD-L1 and CD24 are risk factors for poor prognosis in HBV-associated HCC patients following curative resection. PD-L1 is significantly correlated with CD24 and CD47.https://doi.org/10.1038/s41598-024-83145-5HBV-associated hepatocellular carcinomaImmune checkpoint inhibitorsPD-L1CD24CD47 |
| spellingShingle | Aiping Lin Mingxia Wang Zhihui Wang Juan Lin Zhihui Lin Shaowei Lin Shiyun Lu Hong Lin Haijun Tang Xueping Huang Expression and relationship of PD-L1, CD24, and CD47 in hepatitis B virus associated hepatocellular carcinoma Scientific Reports HBV-associated hepatocellular carcinoma Immune checkpoint inhibitors PD-L1 CD24 CD47 |
| title | Expression and relationship of PD-L1, CD24, and CD47 in hepatitis B virus associated hepatocellular carcinoma |
| title_full | Expression and relationship of PD-L1, CD24, and CD47 in hepatitis B virus associated hepatocellular carcinoma |
| title_fullStr | Expression and relationship of PD-L1, CD24, and CD47 in hepatitis B virus associated hepatocellular carcinoma |
| title_full_unstemmed | Expression and relationship of PD-L1, CD24, and CD47 in hepatitis B virus associated hepatocellular carcinoma |
| title_short | Expression and relationship of PD-L1, CD24, and CD47 in hepatitis B virus associated hepatocellular carcinoma |
| title_sort | expression and relationship of pd l1 cd24 and cd47 in hepatitis b virus associated hepatocellular carcinoma |
| topic | HBV-associated hepatocellular carcinoma Immune checkpoint inhibitors PD-L1 CD24 CD47 |
| url | https://doi.org/10.1038/s41598-024-83145-5 |
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