Different Associations between Lipid Levels and Risk for Heart Failure according to Diabetes Progression
Background The relationship between circulating lipid levels and the risk for heart failure (HF) is controversial. We aimed to examine this association, and whether it is modified by the duration of diabetes or treatment regimens in people with type 2 diabetes mellitus. Methods Individuals (n=2,439,...
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Korean Diabetes Association
2025-01-01
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| Series: | Diabetes & Metabolism Journal |
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| Online Access: | http://e-dmj.org/upload/pdf/dmj-2024-0066.pdf |
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| author | Seung-Hwan Lee Kyu Na Lee Jong-Chan Youn Hun Sung Kim Kyungdo Han Mee Kyoung Kim |
| author_facet | Seung-Hwan Lee Kyu Na Lee Jong-Chan Youn Hun Sung Kim Kyungdo Han Mee Kyoung Kim |
| author_sort | Seung-Hwan Lee |
| collection | DOAJ |
| description | Background The relationship between circulating lipid levels and the risk for heart failure (HF) is controversial. We aimed to examine this association, and whether it is modified by the duration of diabetes or treatment regimens in people with type 2 diabetes mellitus. Methods Individuals (n=2,439,978) who underwent health examinations in 2015 to 2016 were identified from the Korean National Health Information Database. Subjects were categorized according to the duration of diabetes (new-onset, <5, 5–10, or ≥10 years) and number of antidiabetic medications. Incident HF was defined according to the International Classification of Diseases, 10th Revision (ICD-10) code I50 as the primary diagnosis during hospitalization. The risk for HF was estimated using multivariate Cox proportional hazard analysis. Results During a median follow-up of 4.0 years, 151,624 cases of HF occurred. An inverse association between low-density lipoprotein cholesterol (LDL-C) levels and incident HF was observed in the new-onset diabetes group, with an approximately 25% lower risk in those with LDL-C levels of 100–129, 130–159, and ≥160 mg/dL, compared to those with levels <70 mg/dL. However, J-shaped associations were noted in the long-standing diabetes group, with a 16% higher risk in those with LDL-C level ≥160 mg/dL, compared to those with levels <70 mg/dL. Similar patterns were observed in the relationship between total cholesterol or non-high-density lipoprotein cholesterol and the risk for HF, and when subjects were grouped according to the number of antidiabetic medications instead of diabetes duration. Conclusion Different associations between lipid levels and the risk for HF were noted according to disease progression status among individuals with diabetes. |
| format | Article |
| id | doaj-art-3d6de4d11275492f9d8730878a50ca76 |
| institution | Kabale University |
| issn | 2233-6079 2233-6087 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Korean Diabetes Association |
| record_format | Article |
| series | Diabetes & Metabolism Journal |
| spelling | doaj-art-3d6de4d11275492f9d8730878a50ca762025-01-15T07:46:19ZengKorean Diabetes AssociationDiabetes & Metabolism Journal2233-60792233-60872025-01-0149110511610.4093/dmj.2024.00662874Different Associations between Lipid Levels and Risk for Heart Failure according to Diabetes ProgressionSeung-Hwan Lee0Kyu Na Lee1Jong-Chan Youn2Hun Sung Kim3Kyungdo Han4Mee Kyoung Kim5 Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Department of Statistics and Actuarial Science, Soongsil University, Seoul, Korea Division of Cardiology, Department of Internal Medicine, Seoul St. Mary’s Hospital, Catholic Research Institute for Intractable Cardiovascular Disease, College of Medicine, The Catholic University of Korea, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Department of Statistics and Actuarial Science, Soongsil University, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, KoreaBackground The relationship between circulating lipid levels and the risk for heart failure (HF) is controversial. We aimed to examine this association, and whether it is modified by the duration of diabetes or treatment regimens in people with type 2 diabetes mellitus. Methods Individuals (n=2,439,978) who underwent health examinations in 2015 to 2016 were identified from the Korean National Health Information Database. Subjects were categorized according to the duration of diabetes (new-onset, <5, 5–10, or ≥10 years) and number of antidiabetic medications. Incident HF was defined according to the International Classification of Diseases, 10th Revision (ICD-10) code I50 as the primary diagnosis during hospitalization. The risk for HF was estimated using multivariate Cox proportional hazard analysis. Results During a median follow-up of 4.0 years, 151,624 cases of HF occurred. An inverse association between low-density lipoprotein cholesterol (LDL-C) levels and incident HF was observed in the new-onset diabetes group, with an approximately 25% lower risk in those with LDL-C levels of 100–129, 130–159, and ≥160 mg/dL, compared to those with levels <70 mg/dL. However, J-shaped associations were noted in the long-standing diabetes group, with a 16% higher risk in those with LDL-C level ≥160 mg/dL, compared to those with levels <70 mg/dL. Similar patterns were observed in the relationship between total cholesterol or non-high-density lipoprotein cholesterol and the risk for HF, and when subjects were grouped according to the number of antidiabetic medications instead of diabetes duration. Conclusion Different associations between lipid levels and the risk for HF were noted according to disease progression status among individuals with diabetes.http://e-dmj.org/upload/pdf/dmj-2024-0066.pdfcholesterol, ldldiabetes mellitusheart failurelipids |
| spellingShingle | Seung-Hwan Lee Kyu Na Lee Jong-Chan Youn Hun Sung Kim Kyungdo Han Mee Kyoung Kim Different Associations between Lipid Levels and Risk for Heart Failure according to Diabetes Progression Diabetes & Metabolism Journal cholesterol, ldl diabetes mellitus heart failure lipids |
| title | Different Associations between Lipid Levels and Risk for Heart Failure according to Diabetes Progression |
| title_full | Different Associations between Lipid Levels and Risk for Heart Failure according to Diabetes Progression |
| title_fullStr | Different Associations between Lipid Levels and Risk for Heart Failure according to Diabetes Progression |
| title_full_unstemmed | Different Associations between Lipid Levels and Risk for Heart Failure according to Diabetes Progression |
| title_short | Different Associations between Lipid Levels and Risk for Heart Failure according to Diabetes Progression |
| title_sort | different associations between lipid levels and risk for heart failure according to diabetes progression |
| topic | cholesterol, ldl diabetes mellitus heart failure lipids |
| url | http://e-dmj.org/upload/pdf/dmj-2024-0066.pdf |
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