Yin Yang 1 and guanine quadruplexes protect dopaminergic neurons from cellular stress via transmissive dormancy

Abstract Neurons deploy diverse adaptive strategies to ensure survival and neurotransmission amid cellular stress. When these adaptive pathways are overwhelmed, functional impairment or neurodegeneration follows. Here we show that stressed neurons actively induce a state of transmissive dormancy as...

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Main Authors: Kielen R. Zuurbier, Rene Solano Fonseca, Sonja L. B. Arneaud, Jordan M. Wall, Juhee Kim, Lexus Tatge, Gupse Otuzoglu, Sofia Bali, Patrick Metang, Peter M. Douglas
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54958-9
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