RETRACTED ARTICLE: Functionalized graphene oxide nanosheets with folic acid and silk fibroin as a novel nanobiocomposite for biomedical applications
Abstract In this paper, a novel graphene oxide-folic acid/silk fibroin (GO-FA/SF) nanobiocomposite scaffold was designed and fabricated using affordable and non-toxic materials. The GO was synthesized using the hummer method, covalently functionalized with FA, and then easily conjugated with extract...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-10212-0 |
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| author | Reza Eivazzadeh-Keihan Farkhondeh Alimirzaloo Hooman Aghamirza Moghim Aliabadi Ehsan Bahojb Noruzi Ali Reza Akbarzadeh Ali Maleki Hamid Madanchi Mohammad Mahdavi |
| author_facet | Reza Eivazzadeh-Keihan Farkhondeh Alimirzaloo Hooman Aghamirza Moghim Aliabadi Ehsan Bahojb Noruzi Ali Reza Akbarzadeh Ali Maleki Hamid Madanchi Mohammad Mahdavi |
| author_sort | Reza Eivazzadeh-Keihan |
| collection | DOAJ |
| description | Abstract In this paper, a novel graphene oxide-folic acid/silk fibroin (GO-FA/SF) nanobiocomposite scaffold was designed and fabricated using affordable and non-toxic materials. The GO was synthesized using the hummer method, covalently functionalized with FA, and then easily conjugated with extracted SF via the freeze-drying process. For characterization of the scaffold, several techniques were employed: Fourier-transform infrared (FT-IR), field emission scanning electron microscopy (FE-SEM), energy dispersive X-ray (EDX), and thermogravimetric analysis (TGA). The cell viability method, hemolysis, and anti-biofilm assays were performed, exploring the biological capability of the nanobiocomposite. The cell viability percentages were 96.67, 96.35 and 97.23% for 24, 48, and 72 h, respectively, and its hemolytic effect was less than 10%. In addition, it was shown that this nanobiocomposite prevents the formation of Pseudomonas aeruginosa biofilm and has antibacterial activity. |
| format | Article |
| id | doaj-art-3d64d00809e74020b52672e798449e81 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2022-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-3d64d00809e74020b52672e798449e812025-01-12T12:25:22ZengNature PortfolioScientific Reports2045-23222022-04-0112111210.1038/s41598-022-10212-0RETRACTED ARTICLE: Functionalized graphene oxide nanosheets with folic acid and silk fibroin as a novel nanobiocomposite for biomedical applicationsReza Eivazzadeh-Keihan0Farkhondeh Alimirzaloo1Hooman Aghamirza Moghim Aliabadi2Ehsan Bahojb Noruzi3Ali Reza Akbarzadeh4Ali Maleki5Hamid Madanchi6Mohammad Mahdavi7Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and TechnologyCatalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and TechnologyProtein Chemistry Laboratory, Department of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute of IranDepartment of Inorganic Chemistry, Faculty of Chemistry, University of TabrizDepartment of Chemistry, Iran University of Science and TechnologyCatalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and TechnologyDepartment of Biotechnology, School of Medicine, Semnan University of Medical SciencesEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical SciencesAbstract In this paper, a novel graphene oxide-folic acid/silk fibroin (GO-FA/SF) nanobiocomposite scaffold was designed and fabricated using affordable and non-toxic materials. The GO was synthesized using the hummer method, covalently functionalized with FA, and then easily conjugated with extracted SF via the freeze-drying process. For characterization of the scaffold, several techniques were employed: Fourier-transform infrared (FT-IR), field emission scanning electron microscopy (FE-SEM), energy dispersive X-ray (EDX), and thermogravimetric analysis (TGA). The cell viability method, hemolysis, and anti-biofilm assays were performed, exploring the biological capability of the nanobiocomposite. The cell viability percentages were 96.67, 96.35 and 97.23% for 24, 48, and 72 h, respectively, and its hemolytic effect was less than 10%. In addition, it was shown that this nanobiocomposite prevents the formation of Pseudomonas aeruginosa biofilm and has antibacterial activity.https://doi.org/10.1038/s41598-022-10212-0 |
| spellingShingle | Reza Eivazzadeh-Keihan Farkhondeh Alimirzaloo Hooman Aghamirza Moghim Aliabadi Ehsan Bahojb Noruzi Ali Reza Akbarzadeh Ali Maleki Hamid Madanchi Mohammad Mahdavi RETRACTED ARTICLE: Functionalized graphene oxide nanosheets with folic acid and silk fibroin as a novel nanobiocomposite for biomedical applications Scientific Reports |
| title | RETRACTED ARTICLE: Functionalized graphene oxide nanosheets with folic acid and silk fibroin as a novel nanobiocomposite for biomedical applications |
| title_full | RETRACTED ARTICLE: Functionalized graphene oxide nanosheets with folic acid and silk fibroin as a novel nanobiocomposite for biomedical applications |
| title_fullStr | RETRACTED ARTICLE: Functionalized graphene oxide nanosheets with folic acid and silk fibroin as a novel nanobiocomposite for biomedical applications |
| title_full_unstemmed | RETRACTED ARTICLE: Functionalized graphene oxide nanosheets with folic acid and silk fibroin as a novel nanobiocomposite for biomedical applications |
| title_short | RETRACTED ARTICLE: Functionalized graphene oxide nanosheets with folic acid and silk fibroin as a novel nanobiocomposite for biomedical applications |
| title_sort | retracted article functionalized graphene oxide nanosheets with folic acid and silk fibroin as a novel nanobiocomposite for biomedical applications |
| url | https://doi.org/10.1038/s41598-022-10212-0 |
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