Large atypical lipomatous tumours of the limbs: A report of three cases
Atypical lipomatous tumours (ALT) are rare adipocytic neoplasms classified under well-differentiated liposarcomas. Although they have low metastatic potential, their progressive growth and anatomical location can lead to significant functional impairments. Complete surgical excision remains the prim...
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| Language: | English |
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Medical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of Medicine
2025-01-01
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| Series: | Scripta Medica |
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| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2025/2490-33292502405A.pdf |
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| author | Amrane Hemza Boussha Toufik Hasrouri Ilies Mekideche Besma Moussa Amrane Benmayouf Nazim Derdous Chaouki Khernane Nacer |
| author_facet | Amrane Hemza Boussha Toufik Hasrouri Ilies Mekideche Besma Moussa Amrane Benmayouf Nazim Derdous Chaouki Khernane Nacer |
| author_sort | Amrane Hemza |
| collection | DOAJ |
| description | Atypical lipomatous tumours (ALT) are rare adipocytic neoplasms classified under well-differentiated liposarcomas. Although they have low metastatic potential, their progressive growth and anatomical location can lead to significant functional impairments. Complete surgical excision remains the primary treatment; however, challenges arise when these tumours are located near critical neurovascular structures. This study presents three clinical cases of large ALT in the limbs, analysing the diagnostic, surgical and prognostic aspects. This study reports on three patients (ages 64, 70 and 69) who presented with large, slowly growing lipomatous masses in the limbs, evolving over several years. The tumours, ranging from 25 to 60 cm in size, were assessed using imaging techniques, including MRI and CT scans. Surgical excision was performed in all cases, ensuring complete tumour resection while preserving adjacent neurovascular structures. Histopathological analysis confirmed the diagnosis of ALT. Postoperative functional recovery and recurrence were monitored over a follow-up period of 24 months. All patients experienced significant clinical improvement, with full restoration of joint mobility and resolution of sensory disturbances. No local tumour recurrence was observed. Postoperative imaging demonstrated effective tissue regeneration without excessive fibrosis or adhesions. The quality-of-life assessment using the Toronto Extremity Salvage Score (TESS) indicated a marked improvement in motor function and autonomy. ALT, despite being a low-grade tumour, requires a multidisciplinary approach for optimal management. Complete surgical excision ensures excellent long-term outcomes, but extended clinical and radiological surveillance remains crucial. Advancements in molecular pathology and imaging techniques may further refine treatment strategies and enhance patient prognosis. |
| format | Article |
| id | doaj-art-3d5f75dba86f47e291de879e0a890335 |
| institution | OA Journals |
| issn | 2490-3329 2303-7954 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Medical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of Medicine |
| record_format | Article |
| series | Scripta Medica |
| spelling | doaj-art-3d5f75dba86f47e291de879e0a8903352025-08-20T02:24:26ZengMedical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of MedicineScripta Medica2490-33292303-79542025-01-0156240541110.5937/scriptamed56-576402490-33292502405ALarge atypical lipomatous tumours of the limbs: A report of three casesAmrane Hemza0https://orcid.org/0009-0006-1123-7953Boussha Toufik1https://orcid.org/0009-0000-8642-2674Hasrouri Ilies2https://orcid.org/0009-0004-8256-0841Mekideche Besma3https://orcid.org/0009-0004-7961-8061Moussa Amrane4https://orcid.org/0000-0002-3117-5693Benmayouf Nazim5https://orcid.org/0009-0003-1838-4081Derdous Chaouki6https://orcid.org/0009-0002-3658-1057Khernane Nacer7https://orcid.org/0000-0001-9107-0343University of Batna 2 - Mostefa Ben Boulaid, Faculty of Medicine, Benflis Touhami University Hospital (CHU Batna), Batna, AlgeriaUniversity of Batna 2 - Mostefa Ben Boulaid, Faculty of Medicine, Benflis Touhami University Hospital (CHU Batna), Batna, AlgeriaUniversity of Batna 2 - Mostefa Ben Boulaid, Faculty of Medicine, Benflis Touhami University Hospital (CHU Batna), Batna, AlgeriaBatna Specialist Emergency Hospital, Orthopaedic Surgery, Batna, AlgeriaUniversity of Batna 2 - Mostefa Ben Boulaid, Faculty of Technology, Department of Civil Engineering, Laboratory LGC-ROI, Batna, AlgeriaUniversity of Batna 2 - Mostefa Ben Boulaid, Faculty of Medicine, Benflis Touhami University Hospital (CHU Batna), Batna, AlgeriaUniversity of Batna 2 - Mostefa Ben Boulaid, Faculty of Medicine, Benflis Touhami University Hospital (CHU Batna), Batna, AlgeriaUniversity of Batna 2 - Mostefa Ben Boulaid, Faculty of Medicine, Benflis Touhami University Hospital (CHU Batna), Batna, AlgeriaAtypical lipomatous tumours (ALT) are rare adipocytic neoplasms classified under well-differentiated liposarcomas. Although they have low metastatic potential, their progressive growth and anatomical location can lead to significant functional impairments. Complete surgical excision remains the primary treatment; however, challenges arise when these tumours are located near critical neurovascular structures. This study presents three clinical cases of large ALT in the limbs, analysing the diagnostic, surgical and prognostic aspects. This study reports on three patients (ages 64, 70 and 69) who presented with large, slowly growing lipomatous masses in the limbs, evolving over several years. The tumours, ranging from 25 to 60 cm in size, were assessed using imaging techniques, including MRI and CT scans. Surgical excision was performed in all cases, ensuring complete tumour resection while preserving adjacent neurovascular structures. Histopathological analysis confirmed the diagnosis of ALT. Postoperative functional recovery and recurrence were monitored over a follow-up period of 24 months. All patients experienced significant clinical improvement, with full restoration of joint mobility and resolution of sensory disturbances. No local tumour recurrence was observed. Postoperative imaging demonstrated effective tissue regeneration without excessive fibrosis or adhesions. The quality-of-life assessment using the Toronto Extremity Salvage Score (TESS) indicated a marked improvement in motor function and autonomy. ALT, despite being a low-grade tumour, requires a multidisciplinary approach for optimal management. Complete surgical excision ensures excellent long-term outcomes, but extended clinical and radiological surveillance remains crucial. Advancements in molecular pathology and imaging techniques may further refine treatment strategies and enhance patient prognosis.https://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2025/2490-33292502405A.pdfliposarcoma, atypicalwell-differentiated liposarcomasurgical procedures, operativeprognosisrecurrence |
| spellingShingle | Amrane Hemza Boussha Toufik Hasrouri Ilies Mekideche Besma Moussa Amrane Benmayouf Nazim Derdous Chaouki Khernane Nacer Large atypical lipomatous tumours of the limbs: A report of three cases Scripta Medica liposarcoma, atypical well-differentiated liposarcoma surgical procedures, operative prognosis recurrence |
| title | Large atypical lipomatous tumours of the limbs: A report of three cases |
| title_full | Large atypical lipomatous tumours of the limbs: A report of three cases |
| title_fullStr | Large atypical lipomatous tumours of the limbs: A report of three cases |
| title_full_unstemmed | Large atypical lipomatous tumours of the limbs: A report of three cases |
| title_short | Large atypical lipomatous tumours of the limbs: A report of three cases |
| title_sort | large atypical lipomatous tumours of the limbs a report of three cases |
| topic | liposarcoma, atypical well-differentiated liposarcoma surgical procedures, operative prognosis recurrence |
| url | https://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2025/2490-33292502405A.pdf |
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