Serum retinol concentration in patients with acute falciparum malaria
Background: Vitamin A (retinol)-deficiency and falciparum malaria are two major public health problems in developing countries. Falciparum malaria is associated with significant destruction of erythrocytes and can lead to severe anaemia. Methodology: The present study was designed to estimate the...
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| Format: | Article |
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The Journal of Infection in Developing Countries
2009-12-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/148 |
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| author | Adil Raza Haris M Khan Mohd. Ashraf Malik Abbas Ali Mahdi Mohd. Shahid Fatima Shujatullah |
| author_facet | Adil Raza Haris M Khan Mohd. Ashraf Malik Abbas Ali Mahdi Mohd. Shahid Fatima Shujatullah |
| author_sort | Adil Raza |
| collection | DOAJ |
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Background: Vitamin A (retinol)-deficiency and falciparum malaria are two major public health problems in developing countries. Falciparum malaria is associated with significant destruction of erythrocytes and can lead to severe anaemia.
Methodology: The present study was designed to estimate the serum retinol concentration in 150 acute falciparum-malaria patients (aged two to five years) by High Performance Liquid Chromatography (HPLC). Serum retinol concentrations of 20 healthy (age and sex matched, population based) volunteers were included as controls.
Results: The mean serum retinol concentration of healthy controls was 34.31 ± 1.274 µg/dl and that of diseased cohort was 12.562 ± 0.276 µg/dl. The mean parasitemia was 1239.2 ± 33.609 per µL.
Conclusions: The diseased cohort demonstrated significant reduction in concentrations of retinol in comparison to healthy controls (p < 0.001) and there was an inverse relationship (coefficient of correlation r = -0.899) between parasitemia and serum retinol concentration.
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| format | Article |
| id | doaj-art-3d5e08024c2f4e548db25ed6ac8590a4 |
| institution | DOAJ |
| issn | 1972-2680 |
| language | English |
| publishDate | 2009-12-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-3d5e08024c2f4e548db25ed6ac8590a42025-08-20T02:57:16ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802009-12-0131110.3855/jidc.148Serum retinol concentration in patients with acute falciparum malariaAdil Raza0Haris M Khan1Mohd. Ashraf Malik2Abbas Ali Mahdi3Mohd. Shahid4Fatima Shujatullah5Department of Microbiology, J.N. Medical College and Hospital, AMUDepartment of Microbiology, J.N. Medical College and Hospital, AMUDepartment of Paediatrics, J.N. Medical College and Hospital, AMUDepartment of Biochemistry, King George Medical University, LucknowDepartment of Microbiology, J.N. Medical College and Hospital, AMUDepartment of Microbiology, J.N. Medical College and Hospital, AMU Background: Vitamin A (retinol)-deficiency and falciparum malaria are two major public health problems in developing countries. Falciparum malaria is associated with significant destruction of erythrocytes and can lead to severe anaemia. Methodology: The present study was designed to estimate the serum retinol concentration in 150 acute falciparum-malaria patients (aged two to five years) by High Performance Liquid Chromatography (HPLC). Serum retinol concentrations of 20 healthy (age and sex matched, population based) volunteers were included as controls. Results: The mean serum retinol concentration of healthy controls was 34.31 ± 1.274 µg/dl and that of diseased cohort was 12.562 ± 0.276 µg/dl. The mean parasitemia was 1239.2 ± 33.609 per µL. Conclusions: The diseased cohort demonstrated significant reduction in concentrations of retinol in comparison to healthy controls (p < 0.001) and there was an inverse relationship (coefficient of correlation r = -0.899) between parasitemia and serum retinol concentration. https://jidc.org/index.php/journal/article/view/148falciparum- malariaserum retinolparasitemiaIndia |
| spellingShingle | Adil Raza Haris M Khan Mohd. Ashraf Malik Abbas Ali Mahdi Mohd. Shahid Fatima Shujatullah Serum retinol concentration in patients with acute falciparum malaria Journal of Infection in Developing Countries falciparum- malaria serum retinol parasitemia India |
| title | Serum retinol concentration in patients with acute falciparum malaria |
| title_full | Serum retinol concentration in patients with acute falciparum malaria |
| title_fullStr | Serum retinol concentration in patients with acute falciparum malaria |
| title_full_unstemmed | Serum retinol concentration in patients with acute falciparum malaria |
| title_short | Serum retinol concentration in patients with acute falciparum malaria |
| title_sort | serum retinol concentration in patients with acute falciparum malaria |
| topic | falciparum- malaria serum retinol parasitemia India |
| url | https://jidc.org/index.php/journal/article/view/148 |
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