The Role of Cardiac Macrophages in Inflammation and Fibrosis after Myocardial Ischemia-Reperfusion
According to current statistics, the mortality rate of cardiovascular diseases remains high, with coronary artery disease being the primary cause of death. Despite the widespread adoption of percutaneous coronary intervention (PCI) in recent years, which has led to a notable decrease in the mortalit...
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IMR Press
2024-11-01
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| Series: | Reviews in Cardiovascular Medicine |
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| Online Access: | https://www.imrpress.com/journal/RCM/25/11/10.31083/j.rcm2511419 |
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| author | Kaiqin Jin Zijun Ma Xiaohe Wang Chen Gong Jianlong Sheng Jun Chen Shichun Shen |
| author_facet | Kaiqin Jin Zijun Ma Xiaohe Wang Chen Gong Jianlong Sheng Jun Chen Shichun Shen |
| author_sort | Kaiqin Jin |
| collection | DOAJ |
| description | According to current statistics, the mortality rate of cardiovascular diseases remains high, with coronary artery disease being the primary cause of death. Despite the widespread adoption of percutaneous coronary intervention (PCI) in recent years, which has led to a notable decrease in the mortality rate of myocardial infarction (MI), the pathological cardiac remodeling and heart failure that follow myocardial infarction still pose significant clinical challenges. Myocardial ischemia-reperfusion (MIR) injury represents a complex pathophysiological process, and the involvement of macrophages in this injury has consistently been a subject of significant focus. Following MIR, macrophages infiltrate, engulfing tissue debris and necrotic cells, and secreting pro-inflammatory factors. This initial response is crucial for clearing damaged tissue. Subsequently, the pro-inflammatory macrophages (M1) transition to an anti-inflammatory phenotype (M2), a shift that is essential for myocardial fibrosis and cardiac remodeling. This process is dynamic, complex, and continuous. To enhance understanding of this process, this review elaborates on the classification and functions of macrophages within the heart, covering recent research on signaling pathways involved in myocardial infarction through subsequent MIR injury and fibrosis. The ultimate aim is to reduce MIR injury, foster a conducive environment for cardiac recovery, and improve clinical outcomes for MI patients. |
| format | Article |
| id | doaj-art-3d5beff772b64a65968df569c57ad2c2 |
| institution | OA Journals |
| issn | 1530-6550 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Reviews in Cardiovascular Medicine |
| spelling | doaj-art-3d5beff772b64a65968df569c57ad2c22025-08-20T02:07:34ZengIMR PressReviews in Cardiovascular Medicine1530-65502024-11-01251141910.31083/j.rcm2511419S1530-6550(24)01550-3The Role of Cardiac Macrophages in Inflammation and Fibrosis after Myocardial Ischemia-ReperfusionKaiqin Jin0Zijun Ma1Xiaohe Wang2Chen Gong3Jianlong Sheng4Jun Chen5Shichun Shen6Department of Cardiology, Sinopharm Dongfeng General Hospital (Hubei Clinical Research Center of Hypertension), Hubei University of Medicine, 442000 Shiyan, Hubei, ChinaSinopharm Dongfeng General Hospital (Hubei Clinical Research Center of Hypertension), Hubei University of Medicine, 442000 Shiyan, Hubei, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Anhui Medical University, 230001 Hefei, Anhui, ChinaDepartment of Pediatrics, The First Affiliated Hospital of Anhui Medical University, 230001 Hefei, Anhui, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Anhui Medical University, 230001 Hefei, Anhui, ChinaSinopharm Dongfeng General Hospital (Hubei Clinical Research Center of Hypertension), Hubei University of Medicine, 442000 Shiyan, Hubei, ChinaDepartment of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, 230001 Hefei, Anhui, ChinaAccording to current statistics, the mortality rate of cardiovascular diseases remains high, with coronary artery disease being the primary cause of death. Despite the widespread adoption of percutaneous coronary intervention (PCI) in recent years, which has led to a notable decrease in the mortality rate of myocardial infarction (MI), the pathological cardiac remodeling and heart failure that follow myocardial infarction still pose significant clinical challenges. Myocardial ischemia-reperfusion (MIR) injury represents a complex pathophysiological process, and the involvement of macrophages in this injury has consistently been a subject of significant focus. Following MIR, macrophages infiltrate, engulfing tissue debris and necrotic cells, and secreting pro-inflammatory factors. This initial response is crucial for clearing damaged tissue. Subsequently, the pro-inflammatory macrophages (M1) transition to an anti-inflammatory phenotype (M2), a shift that is essential for myocardial fibrosis and cardiac remodeling. This process is dynamic, complex, and continuous. To enhance understanding of this process, this review elaborates on the classification and functions of macrophages within the heart, covering recent research on signaling pathways involved in myocardial infarction through subsequent MIR injury and fibrosis. The ultimate aim is to reduce MIR injury, foster a conducive environment for cardiac recovery, and improve clinical outcomes for MI patients.https://www.imrpress.com/journal/RCM/25/11/10.31083/j.rcm2511419cardiac macrophagesmyocardial ischemia-reperfusioninflammationcardiac fibrosistissue repair |
| spellingShingle | Kaiqin Jin Zijun Ma Xiaohe Wang Chen Gong Jianlong Sheng Jun Chen Shichun Shen The Role of Cardiac Macrophages in Inflammation and Fibrosis after Myocardial Ischemia-Reperfusion Reviews in Cardiovascular Medicine cardiac macrophages myocardial ischemia-reperfusion inflammation cardiac fibrosis tissue repair |
| title | The Role of Cardiac Macrophages in Inflammation and Fibrosis after Myocardial Ischemia-Reperfusion |
| title_full | The Role of Cardiac Macrophages in Inflammation and Fibrosis after Myocardial Ischemia-Reperfusion |
| title_fullStr | The Role of Cardiac Macrophages in Inflammation and Fibrosis after Myocardial Ischemia-Reperfusion |
| title_full_unstemmed | The Role of Cardiac Macrophages in Inflammation and Fibrosis after Myocardial Ischemia-Reperfusion |
| title_short | The Role of Cardiac Macrophages in Inflammation and Fibrosis after Myocardial Ischemia-Reperfusion |
| title_sort | role of cardiac macrophages in inflammation and fibrosis after myocardial ischemia reperfusion |
| topic | cardiac macrophages myocardial ischemia-reperfusion inflammation cardiac fibrosis tissue repair |
| url | https://www.imrpress.com/journal/RCM/25/11/10.31083/j.rcm2511419 |
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