Plasticity of Hippocampal Excitatory-Inhibitory Balance: Missing the Synaptic Control in the Epileptic Brain
Synaptic plasticity is the capacity generated by experience to modify the neural function and, thereby, adapt our behaviour. Long-term plasticity of glutamatergic and GABAergic transmission occurs in a concerted manner, finely adjusting the excitatory-inhibitory (E/I) balance. Imbalances of E/I func...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2016/8607038 |
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| author | Christian Bonansco Marco Fuenzalida |
| author_facet | Christian Bonansco Marco Fuenzalida |
| author_sort | Christian Bonansco |
| collection | DOAJ |
| description | Synaptic plasticity is the capacity generated by experience to modify the neural function and, thereby, adapt our behaviour. Long-term plasticity of glutamatergic and GABAergic transmission occurs in a concerted manner, finely adjusting the excitatory-inhibitory (E/I) balance. Imbalances of E/I function are related to several neurological diseases including epilepsy. Several evidences have demonstrated that astrocytes are able to control the synaptic plasticity, with astrocytes being active partners in synaptic physiology and E/I balance. Here, we revise molecular evidences showing the epileptic stage as an abnormal form of long-term brain plasticity and propose the possible participation of astrocytes to the abnormal increase of glutamatergic and decrease of GABAergic neurotransmission in epileptic networks. |
| format | Article |
| id | doaj-art-3d5913026fa7464f8ebb880cc18d0509 |
| institution | OA Journals |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-3d5913026fa7464f8ebb880cc18d05092025-08-20T02:39:09ZengWileyNeural Plasticity2090-59041687-54432016-01-01201610.1155/2016/86070388607038Plasticity of Hippocampal Excitatory-Inhibitory Balance: Missing the Synaptic Control in the Epileptic BrainChristian Bonansco0Marco Fuenzalida1Centro de Neurobiología y Plasticidad Cerebral (CNPC), Instituto de Fisiología, Facultad de Ciencias, Universidad de Valparaíso, Gran Bretaña Avenida 1111, 2360102 Valparaíso, ChileCentro de Neurobiología y Plasticidad Cerebral (CNPC), Instituto de Fisiología, Facultad de Ciencias, Universidad de Valparaíso, Gran Bretaña Avenida 1111, 2360102 Valparaíso, ChileSynaptic plasticity is the capacity generated by experience to modify the neural function and, thereby, adapt our behaviour. Long-term plasticity of glutamatergic and GABAergic transmission occurs in a concerted manner, finely adjusting the excitatory-inhibitory (E/I) balance. Imbalances of E/I function are related to several neurological diseases including epilepsy. Several evidences have demonstrated that astrocytes are able to control the synaptic plasticity, with astrocytes being active partners in synaptic physiology and E/I balance. Here, we revise molecular evidences showing the epileptic stage as an abnormal form of long-term brain plasticity and propose the possible participation of astrocytes to the abnormal increase of glutamatergic and decrease of GABAergic neurotransmission in epileptic networks.http://dx.doi.org/10.1155/2016/8607038 |
| spellingShingle | Christian Bonansco Marco Fuenzalida Plasticity of Hippocampal Excitatory-Inhibitory Balance: Missing the Synaptic Control in the Epileptic Brain Neural Plasticity |
| title | Plasticity of Hippocampal Excitatory-Inhibitory Balance: Missing the Synaptic Control in the Epileptic Brain |
| title_full | Plasticity of Hippocampal Excitatory-Inhibitory Balance: Missing the Synaptic Control in the Epileptic Brain |
| title_fullStr | Plasticity of Hippocampal Excitatory-Inhibitory Balance: Missing the Synaptic Control in the Epileptic Brain |
| title_full_unstemmed | Plasticity of Hippocampal Excitatory-Inhibitory Balance: Missing the Synaptic Control in the Epileptic Brain |
| title_short | Plasticity of Hippocampal Excitatory-Inhibitory Balance: Missing the Synaptic Control in the Epileptic Brain |
| title_sort | plasticity of hippocampal excitatory inhibitory balance missing the synaptic control in the epileptic brain |
| url | http://dx.doi.org/10.1155/2016/8607038 |
| work_keys_str_mv | AT christianbonansco plasticityofhippocampalexcitatoryinhibitorybalancemissingthesynapticcontrolintheepilepticbrain AT marcofuenzalida plasticityofhippocampalexcitatoryinhibitorybalancemissingthesynapticcontrolintheepilepticbrain |