Hepatocyte‐Targeted Lipid Nanoparticle Delivery of HERC2 Plasmid Controls Drug‐Induced Hepatotoxicity by Limiting β‐Catenin‐Regulated CYP2E1 Expression

Hepatocyte‐Targeted Lipid Nanoparticle Delivery of HERC2 Plasmid Controls Drug‐Induced Hepatotoxicity by Limiting β‐Catenin‐Regulated CYP2E1 Expression

Abstract Understanding the molecular mechanisms that bridge hepatic inflammation and liver injury is crucial for developing effective therapeutic strategies for drug‐induced liver injury (DILI) management. HECT domain and RCC1‐like domain 2 (HERC2) belongs to the large Herc family of ubiquitin E3 li...

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Bibliographic Details
Main Authors: Yunzhi Liu, Qishan Xu, Yan Liu, Sihang Cao, Jialiang Luo, Zhuojun Zheng, Jia Zhou, Xiao Lu, Liyun Zhang, Yanan Tan, Qingyun Chen, Daming Zuo
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Advanced Science
Subjects:
CYP2E1
drug‐induced liver injury
HERC2
lipid nanoparticle
β‐catenin
Online Access:https://doi.org/10.1002/advs.202401633
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