Neoadjuvant Chemotherapy Improves the Immunosuppressive Microenvironment of Bladder Cancer and Increases the Sensitivity to Immune Checkpoint Blockade
Although tumor immune microenvironment plays an important role in antitumor therapy, few studies explored the gene signatures associated with the tumor immune microenvironment of bladder cancer after neoadjuvant chemotherapy. We examined and analyzed differentially expressed genes from 9 patients wi...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2022/9962397 |
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| _version_ | 1850105220071161856 |
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| author | Hao Luo Gao-Lei Liu Dan Jian Dan-Dan Liang Xue-Mei Li Li Zhong Bo Yang Jun Jiang Dong Wang Meng-Xia Li Wei-Hua Lan Nan Dai |
| author_facet | Hao Luo Gao-Lei Liu Dan Jian Dan-Dan Liang Xue-Mei Li Li Zhong Bo Yang Jun Jiang Dong Wang Meng-Xia Li Wei-Hua Lan Nan Dai |
| author_sort | Hao Luo |
| collection | DOAJ |
| description | Although tumor immune microenvironment plays an important role in antitumor therapy, few studies explored the gene signatures associated with the tumor immune microenvironment of bladder cancer after neoadjuvant chemotherapy. We examined and analyzed differentially expressed genes from 9 patients with stage I-III bladder cancer by RNA immune-oncology profiling platform. After neoadjuvant chemotherapy, the expressions of 43 genes in 19 pathways and 10 genes in 5 pathways were upregulated and downregulated, respectively. Neoadjuvant chemotherapy also promoted the expression of genes related to the activation of antitumor immune responses and decreased the expression of genes related to tumor proliferation pathways. In addition, neoadjuvant chemotherapy improved tumor response to immune checkpoint blockade. Furthermore, this study also identified several genes that can be used to predict the efficacy of neoadjuvant chemotherapy and their possible molecular mechanisms. In conclusion, neoadjuvant chemotherapy may promote the activation of antitumor effects, improve the suppressive tumor immune microenvironment, and increase the sensitivity of bladder cancer to immune checkpoint blockade. |
| format | Article |
| id | doaj-art-3d4df949452e4c10a4139903233ccbff |
| institution | OA Journals |
| issn | 2314-7156 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-3d4df949452e4c10a4139903233ccbff2025-08-20T02:39:09ZengWileyJournal of Immunology Research2314-71562022-01-01202210.1155/2022/9962397Neoadjuvant Chemotherapy Improves the Immunosuppressive Microenvironment of Bladder Cancer and Increases the Sensitivity to Immune Checkpoint BlockadeHao Luo0Gao-Lei Liu1Dan Jian2Dan-Dan Liang3Xue-Mei Li4Li Zhong5Bo Yang6Jun Jiang7Dong Wang8Meng-Xia Li9Wei-Hua Lan10Nan Dai11Department of OncologyDepartment of UrologyDepartment of OncologyDepartment of OncologyDepartment of OncologyDepartment of OncologyDepartment of OncologyDepartment of UrologyDepartment of OncologyDepartment of OncologyDepartment of UrologyDepartment of OncologyAlthough tumor immune microenvironment plays an important role in antitumor therapy, few studies explored the gene signatures associated with the tumor immune microenvironment of bladder cancer after neoadjuvant chemotherapy. We examined and analyzed differentially expressed genes from 9 patients with stage I-III bladder cancer by RNA immune-oncology profiling platform. After neoadjuvant chemotherapy, the expressions of 43 genes in 19 pathways and 10 genes in 5 pathways were upregulated and downregulated, respectively. Neoadjuvant chemotherapy also promoted the expression of genes related to the activation of antitumor immune responses and decreased the expression of genes related to tumor proliferation pathways. In addition, neoadjuvant chemotherapy improved tumor response to immune checkpoint blockade. Furthermore, this study also identified several genes that can be used to predict the efficacy of neoadjuvant chemotherapy and their possible molecular mechanisms. In conclusion, neoadjuvant chemotherapy may promote the activation of antitumor effects, improve the suppressive tumor immune microenvironment, and increase the sensitivity of bladder cancer to immune checkpoint blockade.http://dx.doi.org/10.1155/2022/9962397 |
| spellingShingle | Hao Luo Gao-Lei Liu Dan Jian Dan-Dan Liang Xue-Mei Li Li Zhong Bo Yang Jun Jiang Dong Wang Meng-Xia Li Wei-Hua Lan Nan Dai Neoadjuvant Chemotherapy Improves the Immunosuppressive Microenvironment of Bladder Cancer and Increases the Sensitivity to Immune Checkpoint Blockade Journal of Immunology Research |
| title | Neoadjuvant Chemotherapy Improves the Immunosuppressive Microenvironment of Bladder Cancer and Increases the Sensitivity to Immune Checkpoint Blockade |
| title_full | Neoadjuvant Chemotherapy Improves the Immunosuppressive Microenvironment of Bladder Cancer and Increases the Sensitivity to Immune Checkpoint Blockade |
| title_fullStr | Neoadjuvant Chemotherapy Improves the Immunosuppressive Microenvironment of Bladder Cancer and Increases the Sensitivity to Immune Checkpoint Blockade |
| title_full_unstemmed | Neoadjuvant Chemotherapy Improves the Immunosuppressive Microenvironment of Bladder Cancer and Increases the Sensitivity to Immune Checkpoint Blockade |
| title_short | Neoadjuvant Chemotherapy Improves the Immunosuppressive Microenvironment of Bladder Cancer and Increases the Sensitivity to Immune Checkpoint Blockade |
| title_sort | neoadjuvant chemotherapy improves the immunosuppressive microenvironment of bladder cancer and increases the sensitivity to immune checkpoint blockade |
| url | http://dx.doi.org/10.1155/2022/9962397 |
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