Structural optimization of magnesium alloy vascular scaffolds for resistance to vascular plaque stress damage
The majority of researchers primarily focused on the scaffold’s stress and strain in the design of biodegradable magnesium alloy scaffolds. However, in clinical applications, the flawed scaffold structure design will result in acute thrombosis and plaque rupture, which are factors that are often ign...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Materials & Design |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127525004083 |
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| author | Xin Shen Jia She Xianhua Chen Chengzhi Duan Senwei Wang lei Shen Fugui He |
| author_facet | Xin Shen Jia She Xianhua Chen Chengzhi Duan Senwei Wang lei Shen Fugui He |
| author_sort | Xin Shen |
| collection | DOAJ |
| description | The majority of researchers primarily focused on the scaffold’s stress and strain in the design of biodegradable magnesium alloy scaffolds. However, in clinical applications, the flawed scaffold structure design will result in acute thrombosis and plaque rupture, which are factors that are often ignored in scaffold designs. In this research, we report on a new concept, taking vascular plaque stress damage as the design index of scaffold structure, and the finite element multi-objective neural network algorithm is responsible for the optimal design. Mg-xGd-5Y alloy with uniform degradation behavior is used as the basis of BMgS. Based on the observation of radial strength measurement, push measurement and collateral vessel passability measurement conditions verification, the optimized magnesium alloy scaffold was implanted into the coronary arteries of Bama minipigs. Quantitative optical coherence tomography (OCT) was used for observation at 1, 3, and 6 months of follow-up in vivo. Neither early restenosis nor thrombus were seen. The stress-induced damage of vascular plaque offers a novel methodology for the structural design of magnesium alloy scaffolds. Comprehensive validation of in vitro physical and in vivo biomechanical properties confirms the reliability of this approach, thereby advancing the development of biodegradable magnesium scaffolds. |
| format | Article |
| id | doaj-art-3d4d1df7112e41aeb9b4b68f1310d929 |
| institution | DOAJ |
| issn | 0264-1275 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj-art-3d4d1df7112e41aeb9b4b68f1310d9292025-08-20T03:10:51ZengElsevierMaterials & Design0264-12752025-06-0125411398810.1016/j.matdes.2025.113988Structural optimization of magnesium alloy vascular scaffolds for resistance to vascular plaque stress damageXin Shen0Jia She1Xianhua Chen2Chengzhi Duan3Senwei Wang4lei Shen5Fugui He6College of Materials Science and Engineering, Chongqing University, Chongqing, ChinaCollege of Materials Science and Engineering, Chongqing University, Chongqing, China; Corresponding authors at: College of Materials Science and Engineering, Chongqing University, Chongqing, China.College of Materials Science and Engineering, Chongqing University, Chongqing, China; National Engineering Research Center for Mg Alloys, Chongqing University, Chongqing, China; Corresponding authors at: College of Materials Science and Engineering, Chongqing University, Chongqing, China.College of Materials Science and Engineering, Chongqing University, Chongqing, ChinaCollege of Materials Science and Engineering, Chongqing University, Chongqing, ChinaNorth Institute for Science and Technology Information, Beijing, ChinaCollege of Materials Science and Engineering, Chongqing University, Chongqing, ChinaThe majority of researchers primarily focused on the scaffold’s stress and strain in the design of biodegradable magnesium alloy scaffolds. However, in clinical applications, the flawed scaffold structure design will result in acute thrombosis and plaque rupture, which are factors that are often ignored in scaffold designs. In this research, we report on a new concept, taking vascular plaque stress damage as the design index of scaffold structure, and the finite element multi-objective neural network algorithm is responsible for the optimal design. Mg-xGd-5Y alloy with uniform degradation behavior is used as the basis of BMgS. Based on the observation of radial strength measurement, push measurement and collateral vessel passability measurement conditions verification, the optimized magnesium alloy scaffold was implanted into the coronary arteries of Bama minipigs. Quantitative optical coherence tomography (OCT) was used for observation at 1, 3, and 6 months of follow-up in vivo. Neither early restenosis nor thrombus were seen. The stress-induced damage of vascular plaque offers a novel methodology for the structural design of magnesium alloy scaffolds. Comprehensive validation of in vitro physical and in vivo biomechanical properties confirms the reliability of this approach, thereby advancing the development of biodegradable magnesium scaffolds.http://www.sciencedirect.com/science/article/pii/S0264127525004083Magnesium alloy scaffoldFinite element methodStructural design |
| spellingShingle | Xin Shen Jia She Xianhua Chen Chengzhi Duan Senwei Wang lei Shen Fugui He Structural optimization of magnesium alloy vascular scaffolds for resistance to vascular plaque stress damage Materials & Design Magnesium alloy scaffold Finite element method Structural design |
| title | Structural optimization of magnesium alloy vascular scaffolds for resistance to vascular plaque stress damage |
| title_full | Structural optimization of magnesium alloy vascular scaffolds for resistance to vascular plaque stress damage |
| title_fullStr | Structural optimization of magnesium alloy vascular scaffolds for resistance to vascular plaque stress damage |
| title_full_unstemmed | Structural optimization of magnesium alloy vascular scaffolds for resistance to vascular plaque stress damage |
| title_short | Structural optimization of magnesium alloy vascular scaffolds for resistance to vascular plaque stress damage |
| title_sort | structural optimization of magnesium alloy vascular scaffolds for resistance to vascular plaque stress damage |
| topic | Magnesium alloy scaffold Finite element method Structural design |
| url | http://www.sciencedirect.com/science/article/pii/S0264127525004083 |
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