Regulatory roles of RNA binding proteins in the Hippo pathway
Abstract The Hippo pathway represents a highly conserved evolutionary pathway, dysfunction of which has been implicated in various diseases. RNA-binding proteins (RBPs) intricately modulate gene expression through interacting with non-coding RNAs or other proteins. To data, while an array of RBPs ha...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-01-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-025-02316-z |
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| _version_ | 1832571990887628800 |
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| author | Shuchang Peng Chenglin Li Yanwen He Lei Xue Xiaowei Guo |
| author_facet | Shuchang Peng Chenglin Li Yanwen He Lei Xue Xiaowei Guo |
| author_sort | Shuchang Peng |
| collection | DOAJ |
| description | Abstract The Hippo pathway represents a highly conserved evolutionary pathway, dysfunction of which has been implicated in various diseases. RNA-binding proteins (RBPs) intricately modulate gene expression through interacting with non-coding RNAs or other proteins. To data, while an array of RBPs have been identified as modulators of the Hippo pathway, there remains a notable absence of a comprehensive review addressing the mechanistic regulations of RBPs in the transduction of Hippo signaling. Herein, this review aims to consolidate recent advances and elucidate the intricate mechanisms underlying RBPs binding to target RNA. It also explores the dynamic interplay between RBPs, non-coding RNAs, TFs, and DNA on chromatin. Additionally, it also outlines future perspectives, including the essential non-canonical functions of RBPs and emerging roles of non-canonical RBPs as transcription factors (TFs) in genes transcription. Overall, this review provides mechanistic insights into the roles of eukaryotic RBP proteins in the regulation of crucial signaling cascades. |
| format | Article |
| id | doaj-art-3d4c67ad62884c95a15e0be0027fc956 |
| institution | Kabale University |
| issn | 2058-7716 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death Discovery |
| spelling | doaj-art-3d4c67ad62884c95a15e0be0027fc9562025-02-02T12:08:50ZengNature Publishing GroupCell Death Discovery2058-77162025-01-011111610.1038/s41420-025-02316-zRegulatory roles of RNA binding proteins in the Hippo pathwayShuchang Peng0Chenglin Li1Yanwen He2Lei Xue3Xiaowei Guo4The Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province, School of Basic Medical Sciences, Hunan Normal UniversityDepartment of Nuclear Medicine, Shanghai 10th People’s Hospital, School of Life Science and Technology, Tongji UniversityChangsha Stomatological Hospital, Hunan University of Chinese MedicineDepartment of Nuclear Medicine, Shanghai 10th People’s Hospital, School of Life Science and Technology, Tongji UniversityThe Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province, School of Basic Medical Sciences, Hunan Normal UniversityAbstract The Hippo pathway represents a highly conserved evolutionary pathway, dysfunction of which has been implicated in various diseases. RNA-binding proteins (RBPs) intricately modulate gene expression through interacting with non-coding RNAs or other proteins. To data, while an array of RBPs have been identified as modulators of the Hippo pathway, there remains a notable absence of a comprehensive review addressing the mechanistic regulations of RBPs in the transduction of Hippo signaling. Herein, this review aims to consolidate recent advances and elucidate the intricate mechanisms underlying RBPs binding to target RNA. It also explores the dynamic interplay between RBPs, non-coding RNAs, TFs, and DNA on chromatin. Additionally, it also outlines future perspectives, including the essential non-canonical functions of RBPs and emerging roles of non-canonical RBPs as transcription factors (TFs) in genes transcription. Overall, this review provides mechanistic insights into the roles of eukaryotic RBP proteins in the regulation of crucial signaling cascades.https://doi.org/10.1038/s41420-025-02316-z |
| spellingShingle | Shuchang Peng Chenglin Li Yanwen He Lei Xue Xiaowei Guo Regulatory roles of RNA binding proteins in the Hippo pathway Cell Death Discovery |
| title | Regulatory roles of RNA binding proteins in the Hippo pathway |
| title_full | Regulatory roles of RNA binding proteins in the Hippo pathway |
| title_fullStr | Regulatory roles of RNA binding proteins in the Hippo pathway |
| title_full_unstemmed | Regulatory roles of RNA binding proteins in the Hippo pathway |
| title_short | Regulatory roles of RNA binding proteins in the Hippo pathway |
| title_sort | regulatory roles of rna binding proteins in the hippo pathway |
| url | https://doi.org/10.1038/s41420-025-02316-z |
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