Pavlovian cue-evoked alcohol seeking is disrupted by ventral pallidal inhibition
Cues paired with alcohol can be potent drivers of craving, alcohol-seeking, consumption, and relapse. While the ventral pallidum is implicated in appetitive and consummatory responses across several reward classes and types of behaviors, its role in behavioral responses to Pavlovian alcohol cues has...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-12-01
|
| Series: | Addiction Neuroscience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772392524000452 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850218818917367808 |
|---|---|
| author | Jocelyn M. Richard Bailey Newell Preethi Muruganandan Patricia H. Janak Benjamin T. Saunders |
| author_facet | Jocelyn M. Richard Bailey Newell Preethi Muruganandan Patricia H. Janak Benjamin T. Saunders |
| author_sort | Jocelyn M. Richard |
| collection | DOAJ |
| description | Cues paired with alcohol can be potent drivers of craving, alcohol-seeking, consumption, and relapse. While the ventral pallidum is implicated in appetitive and consummatory responses across several reward classes and types of behaviors, its role in behavioral responses to Pavlovian alcohol cues has not previously been established. Here, we tested the impact of optogenetic inhibition of ventral pallidum on Pavlovian-conditioned alcohol-seeking in male Long Evans rats. Rats underwent Pavlovian conditioning with an auditory cue predicting alcohol delivery to a reward port and a control cue predicting no alcohol delivery, until they consistently entered the reward port more during the alcohol cue than the control cue. We then tested the within-session effects of optogenetic inhibition during 50 % of cue presentations. We found that optogenetic inhibition of ventral pallidum during the alcohol cue reduced port entry likelihood and time spent in the port, and increased port entry latency. Overall, these results suggest that normal ventral pallidum activity is necessary for Pavlovian alcohol-seeking. |
| format | Article |
| id | doaj-art-3d4c66daef274dcb81ee5c37c087040b |
| institution | OA Journals |
| issn | 2772-3925 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Addiction Neuroscience |
| spelling | doaj-art-3d4c66daef274dcb81ee5c37c087040b2025-08-20T02:07:35ZengElsevierAddiction Neuroscience2772-39252024-12-011310018610.1016/j.addicn.2024.100186Pavlovian cue-evoked alcohol seeking is disrupted by ventral pallidal inhibitionJocelyn M. Richard0Bailey Newell1Preethi Muruganandan2Patricia H. Janak3Benjamin T. Saunders4Department of Neuroscience, University of Minnesota, Minneapolis, MN 55415, USA; Medical Discovery Team on Addiction, University of Minnesota, Minneapolis, MN 55415, USA; Correspondence author.Department of Neuroscience, University of Minnesota, Minneapolis, MN 55415, USA; Medical Discovery Team on Addiction, University of Minnesota, Minneapolis, MN 55415, USADepartment of Neuroscience, University of Minnesota, Minneapolis, MN 55415, USA; Medical Discovery Team on Addiction, University of Minnesota, Minneapolis, MN 55415, USADepartment of Psychological and Brain Sciences, Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, MD 21218, USA; The Solomon H. Snyder Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USADepartment of Neuroscience, University of Minnesota, Minneapolis, MN 55415, USA; Medical Discovery Team on Addiction, University of Minnesota, Minneapolis, MN 55415, USACues paired with alcohol can be potent drivers of craving, alcohol-seeking, consumption, and relapse. While the ventral pallidum is implicated in appetitive and consummatory responses across several reward classes and types of behaviors, its role in behavioral responses to Pavlovian alcohol cues has not previously been established. Here, we tested the impact of optogenetic inhibition of ventral pallidum on Pavlovian-conditioned alcohol-seeking in male Long Evans rats. Rats underwent Pavlovian conditioning with an auditory cue predicting alcohol delivery to a reward port and a control cue predicting no alcohol delivery, until they consistently entered the reward port more during the alcohol cue than the control cue. We then tested the within-session effects of optogenetic inhibition during 50 % of cue presentations. We found that optogenetic inhibition of ventral pallidum during the alcohol cue reduced port entry likelihood and time spent in the port, and increased port entry latency. Overall, these results suggest that normal ventral pallidum activity is necessary for Pavlovian alcohol-seeking.http://www.sciencedirect.com/science/article/pii/S2772392524000452Ventral pallidumAlcoholPavlovianCues |
| spellingShingle | Jocelyn M. Richard Bailey Newell Preethi Muruganandan Patricia H. Janak Benjamin T. Saunders Pavlovian cue-evoked alcohol seeking is disrupted by ventral pallidal inhibition Addiction Neuroscience Ventral pallidum Alcohol Pavlovian Cues |
| title | Pavlovian cue-evoked alcohol seeking is disrupted by ventral pallidal inhibition |
| title_full | Pavlovian cue-evoked alcohol seeking is disrupted by ventral pallidal inhibition |
| title_fullStr | Pavlovian cue-evoked alcohol seeking is disrupted by ventral pallidal inhibition |
| title_full_unstemmed | Pavlovian cue-evoked alcohol seeking is disrupted by ventral pallidal inhibition |
| title_short | Pavlovian cue-evoked alcohol seeking is disrupted by ventral pallidal inhibition |
| title_sort | pavlovian cue evoked alcohol seeking is disrupted by ventral pallidal inhibition |
| topic | Ventral pallidum Alcohol Pavlovian Cues |
| url | http://www.sciencedirect.com/science/article/pii/S2772392524000452 |
| work_keys_str_mv | AT jocelynmrichard pavloviancueevokedalcoholseekingisdisruptedbyventralpallidalinhibition AT baileynewell pavloviancueevokedalcoholseekingisdisruptedbyventralpallidalinhibition AT preethimuruganandan pavloviancueevokedalcoholseekingisdisruptedbyventralpallidalinhibition AT patriciahjanak pavloviancueevokedalcoholseekingisdisruptedbyventralpallidalinhibition AT benjamintsaunders pavloviancueevokedalcoholseekingisdisruptedbyventralpallidalinhibition |