Rate of Progression in Activity and Participation Outcomes in Exercisers with Parkinson’s Disease: A Five-Year Prospective Longitudinal Study
Background. Rates of progression of motor symptoms and physical performance show declines between 2% and 7% annually in community samples with Parkinson’s disease (PD). However, the effects of ongoing exercise behaviors on progression rates have not been considered. Objective. The primary purpose of...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2019/5679187 |
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| author | Stephanie A. Miller Mindy Mayol Elizabeth S. Moore Audra Heron Victoria Nicholos Brian Ragano |
| author_facet | Stephanie A. Miller Mindy Mayol Elizabeth S. Moore Audra Heron Victoria Nicholos Brian Ragano |
| author_sort | Stephanie A. Miller |
| collection | DOAJ |
| description | Background. Rates of progression of motor symptoms and physical performance show declines between 2% and 7% annually in community samples with Parkinson’s disease (PD). However, the effects of ongoing exercise behaviors on progression rates have not been considered. Objective. The primary purpose of this prospective, longitudinal study was to examine the annual rates of progression in activity and participation measures over five years in community-based exercisers with PD. Methods. A cohort of 55 regular exercisers with idiopathic PD was assessed at baseline and 1, 2, and 5 years. Regular exercise was defined as scores of 4-5 on the Stages for Readiness to Exercise Scale and a self-reported average of at least 60 minutes of exercise/week within six months of each testing session. Unadjusted and adjusted annual progression rates for activity and participation measures were calculated with a standardized equation of change from baseline. A linear mixed model with covariates of age at PD diagnosis and PD subtype was used to determine adjusted change scores. Results. Annual progression rates for unadjusted and adjusted variables were similar, and none exceeded 1.7% across time points for this group of exercisers with PD. Older age at PD diagnosis significantly contributed to faster progression of walking and balance functions. A nonlinear trajectory of the PD progression was demonstrated across most activity and participation outcomes. Conclusions. Annual progression rates demonstrated by this sample of exercisers were lower than those previously reported for motor decline in general samples with PD. Assessing activity and participation outcomes longitudinally at interim time points was important for understanding the trajectory of change over time. The lower rates of progression in this study warrant further investigation into the long-term effects of exercise in PD. |
| format | Article |
| id | doaj-art-3d4c24f35d2a4434a07dd1d8c40e5d52 |
| institution | OA Journals |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-3d4c24f35d2a4434a07dd1d8c40e5d522025-08-20T02:39:09ZengWileyParkinson's Disease2090-80832042-00802019-01-01201910.1155/2019/56791875679187Rate of Progression in Activity and Participation Outcomes in Exercisers with Parkinson’s Disease: A Five-Year Prospective Longitudinal StudyStephanie A. Miller0Mindy Mayol1Elizabeth S. Moore2Audra Heron3Victoria Nicholos4Brian Ragano5University of Indianapolis, Krannert School of Physical Therapy, 1400 E. Hanna Ave., Indianapolis, IN 46227, USAUniversity of Indianapolis, Exercise Science, Department of Kinesiology, Health and Sport Sciences, 1400 E. Hanna Ave., Indianapolis, IN 46227, USAUniversity of Indianapolis, Interprofessional Health and Aging Studies, 1400 E. Hanna Ave., Indianapolis, IN 46227, USAUniversity of Indianapolis, Krannert School of Physical Therapy, 1400 E. Hanna Ave., Indianapolis, IN 46227, USAUniversity of Indianapolis, Krannert School of Physical Therapy, 1400 E. Hanna Ave., Indianapolis, IN 46227, USAUniversity of Indianapolis, Krannert School of Physical Therapy, 1400 E. Hanna Ave., Indianapolis, IN 46227, USABackground. Rates of progression of motor symptoms and physical performance show declines between 2% and 7% annually in community samples with Parkinson’s disease (PD). However, the effects of ongoing exercise behaviors on progression rates have not been considered. Objective. The primary purpose of this prospective, longitudinal study was to examine the annual rates of progression in activity and participation measures over five years in community-based exercisers with PD. Methods. A cohort of 55 regular exercisers with idiopathic PD was assessed at baseline and 1, 2, and 5 years. Regular exercise was defined as scores of 4-5 on the Stages for Readiness to Exercise Scale and a self-reported average of at least 60 minutes of exercise/week within six months of each testing session. Unadjusted and adjusted annual progression rates for activity and participation measures were calculated with a standardized equation of change from baseline. A linear mixed model with covariates of age at PD diagnosis and PD subtype was used to determine adjusted change scores. Results. Annual progression rates for unadjusted and adjusted variables were similar, and none exceeded 1.7% across time points for this group of exercisers with PD. Older age at PD diagnosis significantly contributed to faster progression of walking and balance functions. A nonlinear trajectory of the PD progression was demonstrated across most activity and participation outcomes. Conclusions. Annual progression rates demonstrated by this sample of exercisers were lower than those previously reported for motor decline in general samples with PD. Assessing activity and participation outcomes longitudinally at interim time points was important for understanding the trajectory of change over time. The lower rates of progression in this study warrant further investigation into the long-term effects of exercise in PD.http://dx.doi.org/10.1155/2019/5679187 |
| spellingShingle | Stephanie A. Miller Mindy Mayol Elizabeth S. Moore Audra Heron Victoria Nicholos Brian Ragano Rate of Progression in Activity and Participation Outcomes in Exercisers with Parkinson’s Disease: A Five-Year Prospective Longitudinal Study Parkinson's Disease |
| title | Rate of Progression in Activity and Participation Outcomes in Exercisers with Parkinson’s Disease: A Five-Year Prospective Longitudinal Study |
| title_full | Rate of Progression in Activity and Participation Outcomes in Exercisers with Parkinson’s Disease: A Five-Year Prospective Longitudinal Study |
| title_fullStr | Rate of Progression in Activity and Participation Outcomes in Exercisers with Parkinson’s Disease: A Five-Year Prospective Longitudinal Study |
| title_full_unstemmed | Rate of Progression in Activity and Participation Outcomes in Exercisers with Parkinson’s Disease: A Five-Year Prospective Longitudinal Study |
| title_short | Rate of Progression in Activity and Participation Outcomes in Exercisers with Parkinson’s Disease: A Five-Year Prospective Longitudinal Study |
| title_sort | rate of progression in activity and participation outcomes in exercisers with parkinson s disease a five year prospective longitudinal study |
| url | http://dx.doi.org/10.1155/2019/5679187 |
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