Ileocecal Adenocarcinoma and Ureteral Transitional Cell Carcinoma with Multiple Sebaceous Tumors and Keratoacanthomas in a Case of Muir-Torre Syndrome
Cutaneous neoplasms including sebaceous tumors, keratoacanthomas, and basal cell carcinomas with sebaceous differentiation can be markers of internal malignancy associated with the Muir-Torre Syndrome (MTS). We report a 56-year-old man with a diagnosis of hereditary nonpolyposis colorectal cancer (H...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
|
| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2010/173160 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832563354057572352 |
|---|---|
| author | Michael C. Lynch Bryan E. Anderson |
| author_facet | Michael C. Lynch Bryan E. Anderson |
| author_sort | Michael C. Lynch |
| collection | DOAJ |
| description | Cutaneous neoplasms including sebaceous tumors, keratoacanthomas, and basal cell carcinomas with sebaceous differentiation can be markers of internal malignancy associated with the Muir-Torre Syndrome (MTS). We report a 56-year-old man with a diagnosis of hereditary nonpolyposis colorectal cancer (HNPCC) and ureteral transitional cell carcinoma who subsequently developed two sebaceous gland neoplasms and several keratoacanthomas, leading to the diagnosis of MTS. Our case highlights the clinical advantages of immunohistochemistry (IHC) in identifying mutations in the mismatch repair (MMR) genes responsible for both HNPCC and MTS. The importance of continued clinical suspicion in the dermatological assessment of patients with sebaceous neoplasms is emphasized. |
| format | Article |
| id | doaj-art-3d484adaa4ed4fb09a771853ad2fb10a |
| institution | Kabale University |
| issn | 1687-6105 1687-6113 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Dermatology Research and Practice |
| spelling | doaj-art-3d484adaa4ed4fb09a771853ad2fb10a2025-02-03T01:20:22ZengWileyDermatology Research and Practice1687-61051687-61132010-01-01201010.1155/2010/173160173160Ileocecal Adenocarcinoma and Ureteral Transitional Cell Carcinoma with Multiple Sebaceous Tumors and Keratoacanthomas in a Case of Muir-Torre SyndromeMichael C. Lynch0Bryan E. Anderson1Department of Dermatology, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033-0850, USADepartment of Dermatology, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033-0850, USACutaneous neoplasms including sebaceous tumors, keratoacanthomas, and basal cell carcinomas with sebaceous differentiation can be markers of internal malignancy associated with the Muir-Torre Syndrome (MTS). We report a 56-year-old man with a diagnosis of hereditary nonpolyposis colorectal cancer (HNPCC) and ureteral transitional cell carcinoma who subsequently developed two sebaceous gland neoplasms and several keratoacanthomas, leading to the diagnosis of MTS. Our case highlights the clinical advantages of immunohistochemistry (IHC) in identifying mutations in the mismatch repair (MMR) genes responsible for both HNPCC and MTS. The importance of continued clinical suspicion in the dermatological assessment of patients with sebaceous neoplasms is emphasized.http://dx.doi.org/10.1155/2010/173160 |
| spellingShingle | Michael C. Lynch Bryan E. Anderson Ileocecal Adenocarcinoma and Ureteral Transitional Cell Carcinoma with Multiple Sebaceous Tumors and Keratoacanthomas in a Case of Muir-Torre Syndrome Dermatology Research and Practice |
| title | Ileocecal Adenocarcinoma and Ureteral Transitional Cell Carcinoma with Multiple Sebaceous Tumors and Keratoacanthomas in a Case of Muir-Torre Syndrome |
| title_full | Ileocecal Adenocarcinoma and Ureteral Transitional Cell Carcinoma with Multiple Sebaceous Tumors and Keratoacanthomas in a Case of Muir-Torre Syndrome |
| title_fullStr | Ileocecal Adenocarcinoma and Ureteral Transitional Cell Carcinoma with Multiple Sebaceous Tumors and Keratoacanthomas in a Case of Muir-Torre Syndrome |
| title_full_unstemmed | Ileocecal Adenocarcinoma and Ureteral Transitional Cell Carcinoma with Multiple Sebaceous Tumors and Keratoacanthomas in a Case of Muir-Torre Syndrome |
| title_short | Ileocecal Adenocarcinoma and Ureteral Transitional Cell Carcinoma with Multiple Sebaceous Tumors and Keratoacanthomas in a Case of Muir-Torre Syndrome |
| title_sort | ileocecal adenocarcinoma and ureteral transitional cell carcinoma with multiple sebaceous tumors and keratoacanthomas in a case of muir torre syndrome |
| url | http://dx.doi.org/10.1155/2010/173160 |
| work_keys_str_mv | AT michaelclynch ileocecaladenocarcinomaandureteraltransitionalcellcarcinomawithmultiplesebaceoustumorsandkeratoacanthomasinacaseofmuirtorresyndrome AT bryaneanderson ileocecaladenocarcinomaandureteraltransitionalcellcarcinomawithmultiplesebaceoustumorsandkeratoacanthomasinacaseofmuirtorresyndrome |