Functional Diversity of Fibroblast Growth Factors in Bone Formation
The functional significance of fibroblast growth factor (FGF) signaling in bone formation has been demonstrated through genetic loss-of-function and gain-of-function approaches. FGFs, comprising 22 family members, are classified into three subfamilies: canonical, hormone-like, and intracellular. The...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/729352 |
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| author | Yuichiro Takei Tomoko Minamizaki Yuji Yoshiko |
| author_facet | Yuichiro Takei Tomoko Minamizaki Yuji Yoshiko |
| author_sort | Yuichiro Takei |
| collection | DOAJ |
| description | The functional significance of fibroblast growth factor (FGF) signaling in bone formation has been demonstrated through genetic loss-of-function and gain-of-function approaches. FGFs, comprising 22 family members, are classified into three subfamilies: canonical, hormone-like, and intracellular. The former two subfamilies activate their signaling pathways through FGF receptors (FGFRs). Currently, intracellular FGFs appear to be primarily involved in the nervous system. Canonical FGFs such as FGF2 play significant roles in bone formation, and precise spatiotemporal control of FGFs and FGFRs at the transcriptional and posttranscriptional levels may allow for the functional diversity of FGFs during bone formation. Recently, several research groups, including ours, have shown that FGF23, a member of the hormone-like FGF subfamily, is primarily expressed in osteocytes/osteoblasts. This polypeptide decreases serum phosphate levels by inhibiting renal phosphate reabsorption and vitamin D3 activation, resulting in mineralization defects in the bone. Thus, FGFs are involved in the positive and negative regulation of bone formation. In this review, we focus on the reciprocal roles of FGFs in bone formation in relation to their local versus systemic effects. |
| format | Article |
| id | doaj-art-3d467030c42a4a9ba314dbc78d15d8a5 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-3d467030c42a4a9ba314dbc78d15d8a52025-02-03T07:25:19ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/729352729352Functional Diversity of Fibroblast Growth Factors in Bone FormationYuichiro Takei0Tomoko Minamizaki1Yuji Yoshiko2Department of Calcified Tissue Biology, Hiroshima University Institute of Biomedical & Health Sciences, 1-2-3 Kasumi Minami-ku, Hiroshima 734-8553, JapanDepartment of Calcified Tissue Biology, Hiroshima University Institute of Biomedical & Health Sciences, 1-2-3 Kasumi Minami-ku, Hiroshima 734-8553, JapanDepartment of Calcified Tissue Biology, Hiroshima University Institute of Biomedical & Health Sciences, 1-2-3 Kasumi Minami-ku, Hiroshima 734-8553, JapanThe functional significance of fibroblast growth factor (FGF) signaling in bone formation has been demonstrated through genetic loss-of-function and gain-of-function approaches. FGFs, comprising 22 family members, are classified into three subfamilies: canonical, hormone-like, and intracellular. The former two subfamilies activate their signaling pathways through FGF receptors (FGFRs). Currently, intracellular FGFs appear to be primarily involved in the nervous system. Canonical FGFs such as FGF2 play significant roles in bone formation, and precise spatiotemporal control of FGFs and FGFRs at the transcriptional and posttranscriptional levels may allow for the functional diversity of FGFs during bone formation. Recently, several research groups, including ours, have shown that FGF23, a member of the hormone-like FGF subfamily, is primarily expressed in osteocytes/osteoblasts. This polypeptide decreases serum phosphate levels by inhibiting renal phosphate reabsorption and vitamin D3 activation, resulting in mineralization defects in the bone. Thus, FGFs are involved in the positive and negative regulation of bone formation. In this review, we focus on the reciprocal roles of FGFs in bone formation in relation to their local versus systemic effects.http://dx.doi.org/10.1155/2015/729352 |
| spellingShingle | Yuichiro Takei Tomoko Minamizaki Yuji Yoshiko Functional Diversity of Fibroblast Growth Factors in Bone Formation International Journal of Endocrinology |
| title | Functional Diversity of Fibroblast Growth Factors in Bone Formation |
| title_full | Functional Diversity of Fibroblast Growth Factors in Bone Formation |
| title_fullStr | Functional Diversity of Fibroblast Growth Factors in Bone Formation |
| title_full_unstemmed | Functional Diversity of Fibroblast Growth Factors in Bone Formation |
| title_short | Functional Diversity of Fibroblast Growth Factors in Bone Formation |
| title_sort | functional diversity of fibroblast growth factors in bone formation |
| url | http://dx.doi.org/10.1155/2015/729352 |
| work_keys_str_mv | AT yuichirotakei functionaldiversityoffibroblastgrowthfactorsinboneformation AT tomokominamizaki functionaldiversityoffibroblastgrowthfactorsinboneformation AT yujiyoshiko functionaldiversityoffibroblastgrowthfactorsinboneformation |