UBE2N modulates osteoclast differentiation via BTK-PLCγ2-Ca2+ signaling pathway to promote osteoporosis

UBE2N modulates osteoclast differentiation via BTK-PLCγ2-Ca2+ signaling pathway to promote osteoporosis

Osteoporosis is a prevalent public health issue and the underlying mechanism is an imbalance in bone remodeling. Excessive bone resorption caused by upregulation of osteoclast activity is a key factor in the pathogenesis of osteoporosis. Studies have shown that RNA binding protein (RBP) may play an...

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Bibliographic Details
Main Authors: Yiqing Chen, Ruixue Ying, Liya Ai, Fang Dai, Qiu Zhang, Ping Wang, Fuhua Chen
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Experimental Gerontology
Subjects:
Osteoclast
Bone resorption
UBE2N
BTK-PLCγ2-Ca2+ signaling pathway
Osteoporosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0531556525000804
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