A Presentation of Cerebritis Secondary to Granulomatosis with Polyangiitis (Wegener)
Neurological manifestations of GPA are common, most frequently as a peripheral neuropathy. Cerebritis as a principal presentation is extremely rare. We report a patient who presented with subacute progression of ataxia, confusion, and vacant episodes. An MRI of her brain showed bilateral signal abno...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Neurological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2014/914530 |
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| author | James Norman Ira Pande Timothy Taylor Bruno Gran |
| author_facet | James Norman Ira Pande Timothy Taylor Bruno Gran |
| author_sort | James Norman |
| collection | DOAJ |
| description | Neurological manifestations of GPA are common, most frequently as a peripheral neuropathy. Cerebritis as a principal presentation is extremely rare. We report a patient who presented with subacute progression of ataxia, confusion, and vacant episodes. An MRI of her brain showed bilateral signal abnormalities in the cingulate and superior sagittal gyrus while a staging CT revealed a mass in the right upper lobe of the patient’s lung with a satellite nodule. C-ANCA antibodies specific for PR3 at high titres were positive and a diagnosis of GPA was made. The patient was commenced on intravenous methylprednisolone followed by cyclophosphamide and responded well to treatment. GPA is a rare and treatable differential diagnosis for confused patients with acute or subacute neurological features and unusual MRI findings. |
| format | Article |
| id | doaj-art-3d420f60edef46a2bd6916af3300b5d3 |
| institution | Kabale University |
| issn | 2090-6668 2090-6676 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Neurological Medicine |
| spelling | doaj-art-3d420f60edef46a2bd6916af3300b5d32025-02-03T01:20:22ZengWileyCase Reports in Neurological Medicine2090-66682090-66762014-01-01201410.1155/2014/914530914530A Presentation of Cerebritis Secondary to Granulomatosis with Polyangiitis (Wegener)James Norman0Ira Pande1Timothy Taylor2Bruno Gran3Department of Neurology, Nottingham University Hospitals NHS Trust, Queen's Medical Centre Campus, Nottingham NG7 2UH, UKDepartment of Rheumatology, Nottingham University Hospitals NHS Trust, Queen’s Medical Centre Campus, Nottingham NG7 2UH, UKDepartment of Radiology, Nottingham University Hospitals NHS Trust, Queen’s Medical Centre Campus, Nottingham NG7 2UH, UKDepartment of Neurology, Nottingham University Hospitals NHS Trust, Queen's Medical Centre Campus, Nottingham NG7 2UH, UKNeurological manifestations of GPA are common, most frequently as a peripheral neuropathy. Cerebritis as a principal presentation is extremely rare. We report a patient who presented with subacute progression of ataxia, confusion, and vacant episodes. An MRI of her brain showed bilateral signal abnormalities in the cingulate and superior sagittal gyrus while a staging CT revealed a mass in the right upper lobe of the patient’s lung with a satellite nodule. C-ANCA antibodies specific for PR3 at high titres were positive and a diagnosis of GPA was made. The patient was commenced on intravenous methylprednisolone followed by cyclophosphamide and responded well to treatment. GPA is a rare and treatable differential diagnosis for confused patients with acute or subacute neurological features and unusual MRI findings.http://dx.doi.org/10.1155/2014/914530 |
| spellingShingle | James Norman Ira Pande Timothy Taylor Bruno Gran A Presentation of Cerebritis Secondary to Granulomatosis with Polyangiitis (Wegener) Case Reports in Neurological Medicine |
| title | A Presentation of Cerebritis Secondary to Granulomatosis with Polyangiitis (Wegener) |
| title_full | A Presentation of Cerebritis Secondary to Granulomatosis with Polyangiitis (Wegener) |
| title_fullStr | A Presentation of Cerebritis Secondary to Granulomatosis with Polyangiitis (Wegener) |
| title_full_unstemmed | A Presentation of Cerebritis Secondary to Granulomatosis with Polyangiitis (Wegener) |
| title_short | A Presentation of Cerebritis Secondary to Granulomatosis with Polyangiitis (Wegener) |
| title_sort | presentation of cerebritis secondary to granulomatosis with polyangiitis wegener |
| url | http://dx.doi.org/10.1155/2014/914530 |
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