The association between appendectomy and increased invasion of ascending colon cancer: a retrospective study involving 880 patients
Abstract Background Ascending colon cancer is a subtype of colorectal cancer (CRC), the most common malignant tumor globally. The appendix has been considered to be a vestigial organ and appendectomy is the most routine management of acute appendicitis. However, limited studies have examined the ass...
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BMC
2025-07-01
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| Series: | World Journal of Surgical Oncology |
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| Online Access: | https://doi.org/10.1186/s12957-025-03896-x |
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| author | Xu Sun Rui Li Wen Zhao Dingchang Li Guanglong Dong |
| author_facet | Xu Sun Rui Li Wen Zhao Dingchang Li Guanglong Dong |
| author_sort | Xu Sun |
| collection | DOAJ |
| description | Abstract Background Ascending colon cancer is a subtype of colorectal cancer (CRC), the most common malignant tumor globally. The appendix has been considered to be a vestigial organ and appendectomy is the most routine management of acute appendicitis. However, limited studies have examined the association between appendectomy and the invasion of ascending colon cancer. Methods In this retrospective study, 880 cases of ascending colon cancer were selected. The preoperative and postoperative clinicopathological features were retrospectively studied. Logistic regression was performed and the propensity score matching (PSM) method was used to adjust for confounding factors. Results In total of 880 patients, 133 patients had a history of appendectomy. Patients with a history of appendectomy exhibited a higher proportion of number of lymph node metastasis (LNM) (P = 0.047), T4 stage (P = 0.025), N1 stage (P = 0.037), N2 stage (P = 0.045), M1 stage (P = 0.008), stage III (P = 0.047), and stage IV (P = 0.003). The model following PSM revealed that a history of appendectomy was associated with an increased risk of LNM and M1. In 747 patients without a history of appendectomy, 568 patients (76.0%) were diagnosed with chronic appendicitis pathologically. Patients with chronic appendicitis had significantly smaller tumor sizes (P = 0.012), reduced lymphovascular invasion (LVI) (P = 0.001), fewer poorly differentiated tumors (P = 0.012,), a lower number of LNM (P = 0.020), less frequent T4 stage tumors (P = 0.023), and a decreased incidence of N2 stage disease (P = 0.035). Conclusions Appendectomy is associated with a higher aggressiveness of subsequent ascending colon cancer, particularly regarding LNM. Chronic appendicitis has been linked to a decrease in tumor invasion of ascending colon cancer. |
| format | Article |
| id | doaj-art-3d3e6a9fca764584b1394739fe6929bc |
| institution | Kabale University |
| issn | 1477-7819 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj-art-3d3e6a9fca764584b1394739fe6929bc2025-08-20T04:01:34ZengBMCWorld Journal of Surgical Oncology1477-78192025-07-0123111210.1186/s12957-025-03896-xThe association between appendectomy and increased invasion of ascending colon cancer: a retrospective study involving 880 patientsXu Sun0Rui Li1Wen Zhao2Dingchang Li3Guanglong Dong4Medical School of Chinese PLAMedical School of Chinese PLAMedical School of Chinese PLAMedical School of Chinese PLAMedical School of Chinese PLAAbstract Background Ascending colon cancer is a subtype of colorectal cancer (CRC), the most common malignant tumor globally. The appendix has been considered to be a vestigial organ and appendectomy is the most routine management of acute appendicitis. However, limited studies have examined the association between appendectomy and the invasion of ascending colon cancer. Methods In this retrospective study, 880 cases of ascending colon cancer were selected. The preoperative and postoperative clinicopathological features were retrospectively studied. Logistic regression was performed and the propensity score matching (PSM) method was used to adjust for confounding factors. Results In total of 880 patients, 133 patients had a history of appendectomy. Patients with a history of appendectomy exhibited a higher proportion of number of lymph node metastasis (LNM) (P = 0.047), T4 stage (P = 0.025), N1 stage (P = 0.037), N2 stage (P = 0.045), M1 stage (P = 0.008), stage III (P = 0.047), and stage IV (P = 0.003). The model following PSM revealed that a history of appendectomy was associated with an increased risk of LNM and M1. In 747 patients without a history of appendectomy, 568 patients (76.0%) were diagnosed with chronic appendicitis pathologically. Patients with chronic appendicitis had significantly smaller tumor sizes (P = 0.012), reduced lymphovascular invasion (LVI) (P = 0.001), fewer poorly differentiated tumors (P = 0.012,), a lower number of LNM (P = 0.020), less frequent T4 stage tumors (P = 0.023), and a decreased incidence of N2 stage disease (P = 0.035). Conclusions Appendectomy is associated with a higher aggressiveness of subsequent ascending colon cancer, particularly regarding LNM. Chronic appendicitis has been linked to a decrease in tumor invasion of ascending colon cancer.https://doi.org/10.1186/s12957-025-03896-xColorectal cancerAscending colon cancerAppendixAppendectomyTumor invasion |
| spellingShingle | Xu Sun Rui Li Wen Zhao Dingchang Li Guanglong Dong The association between appendectomy and increased invasion of ascending colon cancer: a retrospective study involving 880 patients World Journal of Surgical Oncology Colorectal cancer Ascending colon cancer Appendix Appendectomy Tumor invasion |
| title | The association between appendectomy and increased invasion of ascending colon cancer: a retrospective study involving 880 patients |
| title_full | The association between appendectomy and increased invasion of ascending colon cancer: a retrospective study involving 880 patients |
| title_fullStr | The association between appendectomy and increased invasion of ascending colon cancer: a retrospective study involving 880 patients |
| title_full_unstemmed | The association between appendectomy and increased invasion of ascending colon cancer: a retrospective study involving 880 patients |
| title_short | The association between appendectomy and increased invasion of ascending colon cancer: a retrospective study involving 880 patients |
| title_sort | association between appendectomy and increased invasion of ascending colon cancer a retrospective study involving 880 patients |
| topic | Colorectal cancer Ascending colon cancer Appendix Appendectomy Tumor invasion |
| url | https://doi.org/10.1186/s12957-025-03896-x |
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