A Sensitive Spectrophotometric Determination of Ritodrine, Pentazocine, Isoxsuprine Hydrochlorides and Amoxicillin in Pure and Pharmaceutical Samples
A simple, accurate and highly sensitive spectrophotometric method for the determination of ritodrine hydrochloride (RTH), pentazocine hydrochloride (PZH), isoxsuprine hydrochloride (ISH) and amoxicillin (AMX) is described. The method is based on the oxidation of the studied drugs by a known excess o...
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2008/476326 |
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| author | H. D. Revanasiddappa M. A. Veena |
| author_facet | H. D. Revanasiddappa M. A. Veena |
| author_sort | H. D. Revanasiddappa |
| collection | DOAJ |
| description | A simple, accurate and highly sensitive spectrophotometric method for the determination of ritodrine hydrochloride (RTH), pentazocine hydrochloride (PZH), isoxsuprine hydrochloride (ISH) and amoxicillin (AMX) is described. The method is based on the oxidation of the studied drugs by a known excess of chloramine – T (CAT) in hydrochloric acid medium and subsequent determination of the unreacted oxidant by reacting it with iodide in the same acid medium liberates iodine, which subsequently react with starch to form a stable starch-iodine complex. The reacted oxidant corresponds to the drug content. The coloured complex exhibits a maximum absorption at 590 nm. The apparent molar absorptivity values and Sandell’s sensitivity values are in the range 6.96x104 - 1.43x105 L mol–1 cm–1 and 2.45-4.30 ng cm–2, respectively. The method was successfully applied to the studied drugs in their dosage forms. The results are reproducible within ±1% and compare favorably with those of official methods of British Pharmacopoeia and the United States Pharmacopoeia. |
| format | Article |
| id | doaj-art-3d3c115cf23d482389a47d219df2a275 |
| institution | OA Journals |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-3d3c115cf23d482389a47d219df2a2752025-08-20T02:39:08ZengWileyE-Journal of Chemistry0973-49452090-98102008-01-015110010610.1155/2008/476326A Sensitive Spectrophotometric Determination of Ritodrine, Pentazocine, Isoxsuprine Hydrochlorides and Amoxicillin in Pure and Pharmaceutical SamplesH. D. Revanasiddappa0M. A. Veena1Department of Chemistry, University of Mysore, Manasagangothri, Mysore-570 006, IndiaDepartment of Chemistry, University of Mysore, Manasagangothri, Mysore-570 006, IndiaA simple, accurate and highly sensitive spectrophotometric method for the determination of ritodrine hydrochloride (RTH), pentazocine hydrochloride (PZH), isoxsuprine hydrochloride (ISH) and amoxicillin (AMX) is described. The method is based on the oxidation of the studied drugs by a known excess of chloramine – T (CAT) in hydrochloric acid medium and subsequent determination of the unreacted oxidant by reacting it with iodide in the same acid medium liberates iodine, which subsequently react with starch to form a stable starch-iodine complex. The reacted oxidant corresponds to the drug content. The coloured complex exhibits a maximum absorption at 590 nm. The apparent molar absorptivity values and Sandell’s sensitivity values are in the range 6.96x104 - 1.43x105 L mol–1 cm–1 and 2.45-4.30 ng cm–2, respectively. The method was successfully applied to the studied drugs in their dosage forms. The results are reproducible within ±1% and compare favorably with those of official methods of British Pharmacopoeia and the United States Pharmacopoeia.http://dx.doi.org/10.1155/2008/476326 |
| spellingShingle | H. D. Revanasiddappa M. A. Veena A Sensitive Spectrophotometric Determination of Ritodrine, Pentazocine, Isoxsuprine Hydrochlorides and Amoxicillin in Pure and Pharmaceutical Samples E-Journal of Chemistry |
| title | A Sensitive Spectrophotometric Determination of Ritodrine, Pentazocine, Isoxsuprine Hydrochlorides and Amoxicillin in Pure and Pharmaceutical Samples |
| title_full | A Sensitive Spectrophotometric Determination of Ritodrine, Pentazocine, Isoxsuprine Hydrochlorides and Amoxicillin in Pure and Pharmaceutical Samples |
| title_fullStr | A Sensitive Spectrophotometric Determination of Ritodrine, Pentazocine, Isoxsuprine Hydrochlorides and Amoxicillin in Pure and Pharmaceutical Samples |
| title_full_unstemmed | A Sensitive Spectrophotometric Determination of Ritodrine, Pentazocine, Isoxsuprine Hydrochlorides and Amoxicillin in Pure and Pharmaceutical Samples |
| title_short | A Sensitive Spectrophotometric Determination of Ritodrine, Pentazocine, Isoxsuprine Hydrochlorides and Amoxicillin in Pure and Pharmaceutical Samples |
| title_sort | sensitive spectrophotometric determination of ritodrine pentazocine isoxsuprine hydrochlorides and amoxicillin in pure and pharmaceutical samples |
| url | http://dx.doi.org/10.1155/2008/476326 |
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