Association between adiponectin concentrations and cardiovascular disease in diabetic patients: a systematic review and meta-analysis.
<h4>Background</h4>This systematic review and meta-analysis of prospective studies evaluates the association between adiponectin concentrations and risk of cardiovascular disease (CVD) in individuals with diabetes mellitus (DM).<h4>Methods</h4>PubMed and Embase were searched...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0078485 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849320932094509056 |
|---|---|
| author | Zhenjie Wu Yunjiu Cheng Lynn Htet Htet Aung Bixun Li |
| author_facet | Zhenjie Wu Yunjiu Cheng Lynn Htet Htet Aung Bixun Li |
| author_sort | Zhenjie Wu |
| collection | DOAJ |
| description | <h4>Background</h4>This systematic review and meta-analysis of prospective studies evaluates the association between adiponectin concentrations and risk of cardiovascular disease (CVD) in individuals with diabetes mellitus (DM).<h4>Methods</h4>PubMed and Embase were searched for prospective studies on the association of adiponectin concentrations and risk of CVD up to June 2013. Random-effect model was selected to pool the relative risk (RR) and 95% CI.<h4>Results</h4>Five prospective cohort studies and one nested case-control studies met the included criterion. The estimated summary RR and 95% CI of five prospective cohort studies for type 2 diabetes comparing top vs low tertile of adiponectin concentrations was 0.99 (95% CI: 0.67-1.45), with significant heterogeneity between studies (p = 0.037, I (2) = 60.9%). This heterogeneity was explained by one study conducted in Korean.<h4>Conclusions</h4>This study represents the first meta-analysis between adiponectin levels and CVD in diabetic patients and indicated no association was found. This result should be verified further by large sample size, long duration of follow-up, and well-designed prospective clinical trials. |
| format | Article |
| id | doaj-art-3d39c0825ddd4526957b8a11a6ff0220 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-3d39c0825ddd4526957b8a11a6ff02202025-08-20T03:49:55ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01811e7848510.1371/journal.pone.0078485Association between adiponectin concentrations and cardiovascular disease in diabetic patients: a systematic review and meta-analysis.Zhenjie WuYunjiu ChengLynn Htet Htet AungBixun Li<h4>Background</h4>This systematic review and meta-analysis of prospective studies evaluates the association between adiponectin concentrations and risk of cardiovascular disease (CVD) in individuals with diabetes mellitus (DM).<h4>Methods</h4>PubMed and Embase were searched for prospective studies on the association of adiponectin concentrations and risk of CVD up to June 2013. Random-effect model was selected to pool the relative risk (RR) and 95% CI.<h4>Results</h4>Five prospective cohort studies and one nested case-control studies met the included criterion. The estimated summary RR and 95% CI of five prospective cohort studies for type 2 diabetes comparing top vs low tertile of adiponectin concentrations was 0.99 (95% CI: 0.67-1.45), with significant heterogeneity between studies (p = 0.037, I (2) = 60.9%). This heterogeneity was explained by one study conducted in Korean.<h4>Conclusions</h4>This study represents the first meta-analysis between adiponectin levels and CVD in diabetic patients and indicated no association was found. This result should be verified further by large sample size, long duration of follow-up, and well-designed prospective clinical trials.https://doi.org/10.1371/journal.pone.0078485 |
| spellingShingle | Zhenjie Wu Yunjiu Cheng Lynn Htet Htet Aung Bixun Li Association between adiponectin concentrations and cardiovascular disease in diabetic patients: a systematic review and meta-analysis. PLoS ONE |
| title | Association between adiponectin concentrations and cardiovascular disease in diabetic patients: a systematic review and meta-analysis. |
| title_full | Association between adiponectin concentrations and cardiovascular disease in diabetic patients: a systematic review and meta-analysis. |
| title_fullStr | Association between adiponectin concentrations and cardiovascular disease in diabetic patients: a systematic review and meta-analysis. |
| title_full_unstemmed | Association between adiponectin concentrations and cardiovascular disease in diabetic patients: a systematic review and meta-analysis. |
| title_short | Association between adiponectin concentrations and cardiovascular disease in diabetic patients: a systematic review and meta-analysis. |
| title_sort | association between adiponectin concentrations and cardiovascular disease in diabetic patients a systematic review and meta analysis |
| url | https://doi.org/10.1371/journal.pone.0078485 |
| work_keys_str_mv | AT zhenjiewu associationbetweenadiponectinconcentrationsandcardiovasculardiseaseindiabeticpatientsasystematicreviewandmetaanalysis AT yunjiucheng associationbetweenadiponectinconcentrationsandcardiovasculardiseaseindiabeticpatientsasystematicreviewandmetaanalysis AT lynnhtethtetaung associationbetweenadiponectinconcentrationsandcardiovasculardiseaseindiabeticpatientsasystematicreviewandmetaanalysis AT bixunli associationbetweenadiponectinconcentrationsandcardiovasculardiseaseindiabeticpatientsasystematicreviewandmetaanalysis |