Microbiome diversity is a modifiable virulence factor for cryptosporidiosis
Cryptosporidium spp. infection causes significant disease in immunosuppressed individuals and children under the age of 5 years. The severity of the pathological presentation of cryptosporidiosis is a function of the host and parasite genotypes, host immune status, and the enteric environment or mic...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Virulence |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21505594.2023.2273004 |
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| author | Georgina. R. Hurle Julii Brainard Kevin. M. Tyler |
| author_facet | Georgina. R. Hurle Julii Brainard Kevin. M. Tyler |
| author_sort | Georgina. R. Hurle |
| collection | DOAJ |
| description | Cryptosporidium spp. infection causes significant disease in immunosuppressed individuals and children under the age of 5 years. The severity of the pathological presentation of cryptosporidiosis is a function of the host and parasite genotypes, host immune status, and the enteric environment or microbiome of the host. Cryptosporidiosis often presents with abdominal pain and severe diarrhoea and is associated with intestinal dysbiosis and inflammation. Our systematic analysis of the available literature revealed that bacterial diversity is reduced during infection in larger animal models, lending support to recent studies which indicate that the use of probiotics or the presence of a naturally diverse gut microbiome can prevent or minimise pathology caused by gastrointestinal pathogens. In summary, we present evidence that the presence of a diverse gut microbiome, natural or induced, reduces both symptomatic pathology and oocyst output. |
| format | Article |
| id | doaj-art-3d352be6d62e4a7faeec0e6e3a5f6073 |
| institution | OA Journals |
| issn | 2150-5594 2150-5608 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Virulence |
| spelling | doaj-art-3d352be6d62e4a7faeec0e6e3a5f60732025-08-20T02:37:42ZengTaylor & Francis GroupVirulence2150-55942150-56082023-12-0114110.1080/21505594.2023.2273004Microbiome diversity is a modifiable virulence factor for cryptosporidiosisGeorgina. R. Hurle0Julii Brainard1Kevin. M. Tyler2Norwich Medical School, University of East Anglia, Norwich, UKNorwich Medical School, University of East Anglia, Norwich, UKNorwich Medical School, University of East Anglia, Norwich, UKCryptosporidium spp. infection causes significant disease in immunosuppressed individuals and children under the age of 5 years. The severity of the pathological presentation of cryptosporidiosis is a function of the host and parasite genotypes, host immune status, and the enteric environment or microbiome of the host. Cryptosporidiosis often presents with abdominal pain and severe diarrhoea and is associated with intestinal dysbiosis and inflammation. Our systematic analysis of the available literature revealed that bacterial diversity is reduced during infection in larger animal models, lending support to recent studies which indicate that the use of probiotics or the presence of a naturally diverse gut microbiome can prevent or minimise pathology caused by gastrointestinal pathogens. In summary, we present evidence that the presence of a diverse gut microbiome, natural or induced, reduces both symptomatic pathology and oocyst output.https://www.tandfonline.com/doi/10.1080/21505594.2023.2273004Cryptosporidium parvummicrobiomemicrobiotadysbiosismetagenomemeta-analysis |
| spellingShingle | Georgina. R. Hurle Julii Brainard Kevin. M. Tyler Microbiome diversity is a modifiable virulence factor for cryptosporidiosis Virulence Cryptosporidium parvum microbiome microbiota dysbiosis metagenome meta-analysis |
| title | Microbiome diversity is a modifiable virulence factor for cryptosporidiosis |
| title_full | Microbiome diversity is a modifiable virulence factor for cryptosporidiosis |
| title_fullStr | Microbiome diversity is a modifiable virulence factor for cryptosporidiosis |
| title_full_unstemmed | Microbiome diversity is a modifiable virulence factor for cryptosporidiosis |
| title_short | Microbiome diversity is a modifiable virulence factor for cryptosporidiosis |
| title_sort | microbiome diversity is a modifiable virulence factor for cryptosporidiosis |
| topic | Cryptosporidium parvum microbiome microbiota dysbiosis metagenome meta-analysis |
| url | https://www.tandfonline.com/doi/10.1080/21505594.2023.2273004 |
| work_keys_str_mv | AT georginarhurle microbiomediversityisamodifiablevirulencefactorforcryptosporidiosis AT juliibrainard microbiomediversityisamodifiablevirulencefactorforcryptosporidiosis AT kevinmtyler microbiomediversityisamodifiablevirulencefactorforcryptosporidiosis |