Dual biological treatments in immune-mediated disorders: a single center experience
Abstract Background Physicians may encounter situations where they need to co-administer omalizumab with non–IgE-targeting monoclonal antibodies. In this study, we share our experience with these dual biologic treatments. Objective To evaluate the efficacy and safety of dual biological therapy using...
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BMC
2025-04-01
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| Series: | BMC Immunology |
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| Online Access: | https://doi.org/10.1186/s12865-025-00705-8 |
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| author | Oded Shamriz Elchanan Parnasa Limor Rubin Aviv Talmon Yaarit Ribak Isaam Hindi Hagit Peleg Ronit Confino-Cohen Yuval Tal |
| author_facet | Oded Shamriz Elchanan Parnasa Limor Rubin Aviv Talmon Yaarit Ribak Isaam Hindi Hagit Peleg Ronit Confino-Cohen Yuval Tal |
| author_sort | Oded Shamriz |
| collection | DOAJ |
| description | Abstract Background Physicians may encounter situations where they need to co-administer omalizumab with non–IgE-targeting monoclonal antibodies. In this study, we share our experience with these dual biologic treatments. Objective To evaluate the efficacy and safety of dual biological therapy using omalizumab and non-IgE-targeting monoclonal antibodies at a single center. Methods We retrospectively reviewed the medical records of adults treated with a dual biological therapy regimen consisting of omalizumab and another biologic between 2020 and 2022. Results Our review identified nine patients (age range: 51–75 years, 7 women and 2 men) who were treated with omalizumab for high Th2 disorders, including chronic spontaneous urticaria (n = 7) and asthma (n = 2). Seven patients received a second biologic for co-existing non-Th2 disorders, while two received an additional biologic to better control their Th2-mediated disorders. The patients were treated with the following biologics: anti-IL-5 agents (mepolizumab [n = 1] and benralizumab [n = 1]), the IL-4/13 inhibitor dupilumab (n = 1), the anti-IL-17 biologic secukinumab (n = 1), the IL-1 inhibitor anakinra (n = 1), the anti-calcitonin gene–related peptide agent fremanezumab (n = 1), and anti-TNF-α agents (etanercept [n = 1], golimumab [n = 1], and adalimumab [n = 1]). Dual biotherapy was administered for 3–34 months with observed clinical improvement. No adverse events or infections were reported. Conclusions Dual biological treatment with omalizumab and another biologic appears to be safe, with no need to discontinue non–IgE-targeting agents during omalizumab therapy. |
| format | Article |
| id | doaj-art-3d2ed6e4f52b46928c1f13cc53583bc2 |
| institution | DOAJ |
| issn | 1471-2172 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Immunology |
| spelling | doaj-art-3d2ed6e4f52b46928c1f13cc53583bc22025-08-20T03:06:49ZengBMCBMC Immunology1471-21722025-04-012611810.1186/s12865-025-00705-8Dual biological treatments in immune-mediated disorders: a single center experienceOded Shamriz0Elchanan Parnasa1Limor Rubin2Aviv Talmon3Yaarit Ribak4Isaam Hindi5Hagit Peleg6Ronit Confino-Cohen7Yuval Tal8Allergy and Clinical Immunology Unit, Department of Medicine, Hadassah Medical Organization, Faculty of Medicine, Hebrew University of JerusalemDivision of Medicine, Hadassah Medical Center, Faculty of Medicine, Hebrew University of JerusalemAllergy and Clinical Immunology Unit, Department of Medicine, Hadassah Medical Organization, Faculty of Medicine, Hebrew University of JerusalemAllergy and Clinical Immunology Unit, Department of Medicine, Hadassah Medical Organization, Faculty of Medicine, Hebrew University of JerusalemAllergy and Clinical Immunology Unit, Department of Medicine, Hadassah Medical Organization, Faculty of Medicine, Hebrew University of JerusalemRheumatology Unit, Hadassah Medical Center, Faculty of Medicine, Hebrew University of JerusalemRheumatology Unit, Hadassah Medical Center, Faculty of Medicine, Hebrew University of JerusalemSackler Faculty of Medicine, University of Tel AvivAllergy and Clinical Immunology Unit, Department of Medicine, Hadassah Medical Organization, Faculty of Medicine, Hebrew University of JerusalemAbstract Background Physicians may encounter situations where they need to co-administer omalizumab with non–IgE-targeting monoclonal antibodies. In this study, we share our experience with these dual biologic treatments. Objective To evaluate the efficacy and safety of dual biological therapy using omalizumab and non-IgE-targeting monoclonal antibodies at a single center. Methods We retrospectively reviewed the medical records of adults treated with a dual biological therapy regimen consisting of omalizumab and another biologic between 2020 and 2022. Results Our review identified nine patients (age range: 51–75 years, 7 women and 2 men) who were treated with omalizumab for high Th2 disorders, including chronic spontaneous urticaria (n = 7) and asthma (n = 2). Seven patients received a second biologic for co-existing non-Th2 disorders, while two received an additional biologic to better control their Th2-mediated disorders. The patients were treated with the following biologics: anti-IL-5 agents (mepolizumab [n = 1] and benralizumab [n = 1]), the IL-4/13 inhibitor dupilumab (n = 1), the anti-IL-17 biologic secukinumab (n = 1), the IL-1 inhibitor anakinra (n = 1), the anti-calcitonin gene–related peptide agent fremanezumab (n = 1), and anti-TNF-α agents (etanercept [n = 1], golimumab [n = 1], and adalimumab [n = 1]). Dual biotherapy was administered for 3–34 months with observed clinical improvement. No adverse events or infections were reported. Conclusions Dual biological treatment with omalizumab and another biologic appears to be safe, with no need to discontinue non–IgE-targeting agents during omalizumab therapy.https://doi.org/10.1186/s12865-025-00705-8OmalizumabBiologicsDual biologicsIgEBiotherapy |
| spellingShingle | Oded Shamriz Elchanan Parnasa Limor Rubin Aviv Talmon Yaarit Ribak Isaam Hindi Hagit Peleg Ronit Confino-Cohen Yuval Tal Dual biological treatments in immune-mediated disorders: a single center experience BMC Immunology Omalizumab Biologics Dual biologics IgE Biotherapy |
| title | Dual biological treatments in immune-mediated disorders: a single center experience |
| title_full | Dual biological treatments in immune-mediated disorders: a single center experience |
| title_fullStr | Dual biological treatments in immune-mediated disorders: a single center experience |
| title_full_unstemmed | Dual biological treatments in immune-mediated disorders: a single center experience |
| title_short | Dual biological treatments in immune-mediated disorders: a single center experience |
| title_sort | dual biological treatments in immune mediated disorders a single center experience |
| topic | Omalizumab Biologics Dual biologics IgE Biotherapy |
| url | https://doi.org/10.1186/s12865-025-00705-8 |
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