Proteomic Approach to Study the Effect of <i>Pneumocystis jirovecii</i> Colonization in Idiopathic Pulmonary Fibrosis
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and interstitial disease with an unclear cause, believed to involve genetic, environmental, and molecular factors. Recent research suggested that <i>Pneumocystis jirovecii</i> (PJ) could contribute to disease exacerbations an...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Journal of Fungi |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2309-608X/11/2/102 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849719881649356800 |
|---|---|
| author | Jonás Carmona-Pírez Rocío Salsoso Eléna Charpentier Cinta Olmedo Francisco J. Medrano Lucas Román Carmen de la Horra Yaxsier de Armas Enrique J. Calderón Vicente Friaza |
| author_facet | Jonás Carmona-Pírez Rocío Salsoso Eléna Charpentier Cinta Olmedo Francisco J. Medrano Lucas Román Carmen de la Horra Yaxsier de Armas Enrique J. Calderón Vicente Friaza |
| author_sort | Jonás Carmona-Pírez |
| collection | DOAJ |
| description | Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and interstitial disease with an unclear cause, believed to involve genetic, environmental, and molecular factors. Recent research suggested that <i>Pneumocystis jirovecii</i> (PJ) could contribute to disease exacerbations and severity. This article explores how PJ colonization might influence the pathogenesis of IPF. We performed a proteomic analysis to study the profile of control and IPF patients, with/without PJ. We recruited nine participants from the Virgen del Rocio University Hospital (Seville, Spain). iTRAQ and bioinformatics analyses were performed to identify differentially expressed proteins (DEPs), including a functional analysis of DEPs and of the protein–protein interaction networks built using the STRING database. We identified a total of 92 DEPs highlighting the protein vimentin when comparing groups. Functional differences were observed, with the glycolysis pathway highlighted in PJ-colonized IPF patients; as well as the pentose phosphate pathway and miR-133A in non-colonized IPF patients. We found 11 protein complexes, notably the JAK-STAT signaling complex in non-colonized IPF patients. To our knowledge, this is the first study that analyzed PJ colonization’s effect on IPF patients. However, further research is needed, especially on the complex interactions with the AKT/GSK-3β/snail pathway that could explain some of our results. |
| format | Article |
| id | doaj-art-3d2e8a9d0f5f41e6817d22f5edb1ce56 |
| institution | DOAJ |
| issn | 2309-608X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj-art-3d2e8a9d0f5f41e6817d22f5edb1ce562025-08-20T03:12:02ZengMDPI AGJournal of Fungi2309-608X2025-01-0111210210.3390/jof11020102Proteomic Approach to Study the Effect of <i>Pneumocystis jirovecii</i> Colonization in Idiopathic Pulmonary FibrosisJonás Carmona-Pírez0Rocío Salsoso1Eléna Charpentier2Cinta Olmedo3Francisco J. Medrano4Lucas Román5Carmen de la Horra6Yaxsier de Armas7Enrique J. Calderón8Vicente Friaza9Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/Consejo Superior de Investigaciones Científicas/Universidad de Sevilla, 41013 Seville, SpainInstituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/Consejo Superior de Investigaciones Científicas/Universidad de Sevilla, 41013 Seville, SpainInstituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/Consejo Superior de Investigaciones Científicas/Universidad de Sevilla, 41013 Seville, SpainUnidad Médico-Quirúrgica de Enfermedades Respiratorias, Hospital Universitario Virgen del Rocío, 41013 Seville, SpainInstituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/Consejo Superior de Investigaciones Científicas/Universidad de Sevilla, 41013 Seville, SpainUnidad Médico-Quirúrgica de Enfermedades Respiratorias, Hospital Universitario Virgen del Rocío, 41013 Seville, SpainInstituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/Consejo Superior de Investigaciones Científicas/Universidad de Sevilla, 41013 Seville, SpainDepartments of Clinical Microbiology Diagnostic and Pathology, Hospital Center of Institute of Tropical Medicine “Pedro Kourí”, Havana 11400, CubaInstituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/Consejo Superior de Investigaciones Científicas/Universidad de Sevilla, 41013 Seville, SpainInstituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/Consejo Superior de Investigaciones Científicas/Universidad de Sevilla, 41013 Seville, SpainIdiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and interstitial disease with an unclear cause, believed to involve genetic, environmental, and molecular factors. Recent research suggested that <i>Pneumocystis jirovecii</i> (PJ) could contribute to disease exacerbations and severity. This article explores how PJ colonization might influence the pathogenesis of IPF. We performed a proteomic analysis to study the profile of control and IPF patients, with/without PJ. We recruited nine participants from the Virgen del Rocio University Hospital (Seville, Spain). iTRAQ and bioinformatics analyses were performed to identify differentially expressed proteins (DEPs), including a functional analysis of DEPs and of the protein–protein interaction networks built using the STRING database. We identified a total of 92 DEPs highlighting the protein vimentin when comparing groups. Functional differences were observed, with the glycolysis pathway highlighted in PJ-colonized IPF patients; as well as the pentose phosphate pathway and miR-133A in non-colonized IPF patients. We found 11 protein complexes, notably the JAK-STAT signaling complex in non-colonized IPF patients. To our knowledge, this is the first study that analyzed PJ colonization’s effect on IPF patients. However, further research is needed, especially on the complex interactions with the AKT/GSK-3β/snail pathway that could explain some of our results.https://www.mdpi.com/2309-608X/11/2/102idiopathic pulmonary fibrosisproteomics<i>Pneumocystis jirovecii</i><i>Pneumocystis</i> colonizationiTRAQ quantificationprotein–protein interaction networks |
| spellingShingle | Jonás Carmona-Pírez Rocío Salsoso Eléna Charpentier Cinta Olmedo Francisco J. Medrano Lucas Román Carmen de la Horra Yaxsier de Armas Enrique J. Calderón Vicente Friaza Proteomic Approach to Study the Effect of <i>Pneumocystis jirovecii</i> Colonization in Idiopathic Pulmonary Fibrosis Journal of Fungi idiopathic pulmonary fibrosis proteomics <i>Pneumocystis jirovecii</i> <i>Pneumocystis</i> colonization iTRAQ quantification protein–protein interaction networks |
| title | Proteomic Approach to Study the Effect of <i>Pneumocystis jirovecii</i> Colonization in Idiopathic Pulmonary Fibrosis |
| title_full | Proteomic Approach to Study the Effect of <i>Pneumocystis jirovecii</i> Colonization in Idiopathic Pulmonary Fibrosis |
| title_fullStr | Proteomic Approach to Study the Effect of <i>Pneumocystis jirovecii</i> Colonization in Idiopathic Pulmonary Fibrosis |
| title_full_unstemmed | Proteomic Approach to Study the Effect of <i>Pneumocystis jirovecii</i> Colonization in Idiopathic Pulmonary Fibrosis |
| title_short | Proteomic Approach to Study the Effect of <i>Pneumocystis jirovecii</i> Colonization in Idiopathic Pulmonary Fibrosis |
| title_sort | proteomic approach to study the effect of i pneumocystis jirovecii i colonization in idiopathic pulmonary fibrosis |
| topic | idiopathic pulmonary fibrosis proteomics <i>Pneumocystis jirovecii</i> <i>Pneumocystis</i> colonization iTRAQ quantification protein–protein interaction networks |
| url | https://www.mdpi.com/2309-608X/11/2/102 |
| work_keys_str_mv | AT jonascarmonapirez proteomicapproachtostudytheeffectofipneumocystisjiroveciiicolonizationinidiopathicpulmonaryfibrosis AT rociosalsoso proteomicapproachtostudytheeffectofipneumocystisjiroveciiicolonizationinidiopathicpulmonaryfibrosis AT elenacharpentier proteomicapproachtostudytheeffectofipneumocystisjiroveciiicolonizationinidiopathicpulmonaryfibrosis AT cintaolmedo proteomicapproachtostudytheeffectofipneumocystisjiroveciiicolonizationinidiopathicpulmonaryfibrosis AT franciscojmedrano proteomicapproachtostudytheeffectofipneumocystisjiroveciiicolonizationinidiopathicpulmonaryfibrosis AT lucasroman proteomicapproachtostudytheeffectofipneumocystisjiroveciiicolonizationinidiopathicpulmonaryfibrosis AT carmendelahorra proteomicapproachtostudytheeffectofipneumocystisjiroveciiicolonizationinidiopathicpulmonaryfibrosis AT yaxsierdearmas proteomicapproachtostudytheeffectofipneumocystisjiroveciiicolonizationinidiopathicpulmonaryfibrosis AT enriquejcalderon proteomicapproachtostudytheeffectofipneumocystisjiroveciiicolonizationinidiopathicpulmonaryfibrosis AT vicentefriaza proteomicapproachtostudytheeffectofipneumocystisjiroveciiicolonizationinidiopathicpulmonaryfibrosis |